Outcome at 2 years of infants with congenital diaphragmatic hernia: a population-based study

Jaillard, Sophie; Pierrat, Véronique; Dubois, A.; Truffert, Patrick; Lequien, P; Wurtz, Alain; Storme, Laurent

doi:10.1016/s0003-4975(02)04278-9

Cited by 203 publications

(184 citation statements)

References 30 publications

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“…Furthermore, the diaphragmatic patch may reduce abdominal pressure and facilitate postoperative ventilation [96]. This contrasts with results of other studies reporting that requirement of a patch is an independent determinant that predicts occurrence of GERD [99,107,108].…”

Section: Prediction Of Gerd In Cdh Survivorsmentioning

confidence: 80%

“…Pathophysiology of growth retardation in CDH is complex and includes catabolic stress in the neonatal period, oral aversion, GERD and an increased caloric requirement due to persistent pulmonary morbidity [108,110].…”

Section: Pathophysiologymentioning

confidence: 99%

“…Some authors reported that 20-30% of their patients remain at or below the 5th percentile for weight, despite optimization of caloric intake [108,110]. Other studies show that nutritional and growth problems are affecting nearly half of the patients [32].…”

Section: Pathophysiologymentioning

confidence: 99%

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The long-term follow-up of patients with a congenital diaphragmatic hernia: a broad spectrum of morbidity

et al. 2008

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Congenital diaphragmatic hernia (CDH) is a life-threatening anomaly with a mortality rate of approximately 40-50%, depending on case selection. It has been suggested that new therapeutic modalities such as nitric oxide (NO), high frequency oxygenation (HFO) and extracorporal membrane oxygenation (ECMO) might decrease mortality associated with pulmonary hypertension and the sequelae of artificial ventilation. When these new therapies indeed prove to be beneficial, a larger number of children with severe forms of CDH might survive, resulting in an increase of CDH-associated complications and/or consequences. In follow-up studies of infants born with CDH, many complications including pulmonary damage, cardiovascular disease, gastro-intestinal disease, failure to thrive, neurocognitive defects and musculoskeletal abnormalities have been described. Long-term pulmonary morbidity in CDH consists of obstructive and restrictive lung function impairments due to altered lung structure and prolonged ventilatory support. CDH has also been associated with persistent pulmonary vascular abnormalities, resulting in pulmonary hypertension in the neonatal period.

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Section: Prediction Of Gerd In Cdh Survivorsmentioning

confidence: 80%

Section: Pathophysiologymentioning

confidence: 99%

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The long-term follow-up of patients with a congenital diaphragmatic hernia: a broad spectrum of morbidity

et al. 2008

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“…Further, in the CDH lung, there is failure of arterial wall thinning associated with normal newborn pulmonary arterial remodeling (14). Despite these pathologic changes, clinical respiratory reserve appears to improve significantly in the first years of life, with very few survivors requiring oxygen in early childhood (7). There are, however, conflicting noninvasive data showing that nearly half of early childhood survivors have signs of PH (11).…”

Section: Discussionmentioning

confidence: 99%

“…Also, respiratory reserve appears to improve significantly in the first years of life, with less than 2% of these children requiring oxygen at 2 y of age (7). However, there is recent evidence that there is a much higher incidence of respiratory tract infections and failure to thrive in these children (8,9).…”

mentioning

confidence: 99%

Pulmonary vascular resistance in repaired congenital diaphragmatic hernia vs. age-matched controls

et al. 2012

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Impact of fetal treatments for congenital diaphragmatic hernia on lung development

Dahl

Lavizzari

Davis

et al. 2022

The Anatomical Record

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The extent of lung hypoplasia impacts the survival and severity of morbidities associated with congenital diaphragmatic hernia (CDH). The alveoli of CDH infants and in experimental models of CDH have thickened septa with fewer type II pneumocytes and capillaries. Fetal treatments of CDH‐risk preterm birth. Therefore, treatments must aim to balance the need for increased gas exchange surface area with the restoration of pulmonary epithelial type II cells and the long‐term respiratory and neurodevelopmental consequences of prematurity. Achievement of sufficient lung development in utero for successful postnatal transition requires adequate intra‐thoracic space for lung growth, maintenance of sufficient volume and appropriate composition of fetal lung fluid, regular fetal breathing movements, appropriate gas exchange area, and ample surfactant production. The review aims to examine the rationale for current and future therapeutic strategies to improve postnatal outcomes of infants with CDH.

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Outcome at 2 years of infants with congenital diaphragmatic hernia: a population-based study

Cited by 203 publications

References 30 publications

The long-term follow-up of patients with a congenital diaphragmatic hernia: a broad spectrum of morbidity

The long-term follow-up of patients with a congenital diaphragmatic hernia: a broad spectrum of morbidity

Pulmonary vascular resistance in repaired congenital diaphragmatic hernia vs. age-matched controls

Impact of fetal treatments for congenital diaphragmatic hernia on lung development

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