Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in <i>Helicobacter pylori</i> positive or negative children with resistant otitis media with effusion

Mel-Hennawi, D; Ahmed, Mohamed

doi:10.1017/s0022215115002182

Cited by 12 publications

(9 citation statements)

References 19 publications

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“…Moreover, Sudhoff et al concluded by stating that further research is needed in order to delineate the presence of H pylori and its role in the pathogenesis of OME. 1 In a recent study by Saki et al heavy colonisation of H pylori was detected by polymerase chain reaction in adenoid tissue and the middle ear for OME cases. 2 The authors concluded that H pylori had a role in the pathogenesis of OME and that the condition was resistant to medical treatment.…”

Section: First Commentmentioning

confidence: 97%

“…This was 'The role of H pylori in the pathogenesis of otitis media with effusion (OME) is a matter of debate, with studies both in favour of it and against it'. Dr Bakshi mentioned that some studies were against the role of H pylori in OME and used a study by Sudhoff et al 1 to support this. Sudhoff and colleagues found little evidence for the existence of H pylori associated OME, but did not deny its role, nor were they against it (as Dr Bakshi pertained in his letter).…”

Section: First Commentmentioning

confidence: 99%

“…Dear Editors, I came across a very interesting study published in your prestigious journal titled 'Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion' by Mel-Hennawi et al 1 The authors have conducted a very meticulous study and I would like to appreciate their effort; however, I have some concerns regarding the methodology and conclusion, which I would like to express through your esteemed journal.…”

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confidence: 99%

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Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion

Bakshi

2016

J. Laryngol. Otol.

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Section: First Commentmentioning

confidence: 97%

Section: First Commentmentioning

confidence: 99%

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confidence: 99%

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Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion

Bakshi

2016

J. Laryngol. Otol.

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“…Our sample consisted of a total of 7,829 patients, including both genders aged between 2 and 75 years. Studies from Egypt (n=18) [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] , Saudi Arabia (n=8) [46][47][48][49][50][51][52][53] , Lebanon (n=6) [54][55][56][57][58][59] , UAE (n=5) [60][61][62][63][64] , Iraq (n=3) [65][66][67] , Qatar (n=3) [68][69][70] , Algeria (n=2) 71,72 , Palestine (n=1) 73 , Morocco (n=1) 74 , Syria (n=1) 75 , Yemen (n=1) 76 Tunisia (n=1) 77…”

Section: Patients and Study Characteristicsmentioning

confidence: 99%

Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis

Afify

Abd-ElGawad

Bahbah

et al. 2021

Preprint

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Purpose: We aimed to conduct an updated systematic review and network meta-analysis (NMA) to estimate the efficacy of Helicobacter pylori (H. pylori) treatment strategies in Arab countries. Methods: We systematically searched PubMed, Scopus, Web of Science (WOS), EBSCO, and EMBASE from inception to July 18, 2020, using boolean operators. Retrieved articles were screened, and relevant data were extracted. We used R programming software to analyze extracted data. Results: Fifty-four articles (n= 7829 patients) were included in the NMA. Pooled overall analysis demonstrated that adjuvant therapy (standard triple or sequential therapy plus another adjuvant drug) was the best treatment with higher odds of eradication rate [OR= 6.42, 95% CI (1.37: 30.05), P-score= 0.21]. Moreover, Seqential therapy (SQT) and Quinolone based therapy (QBT) were associated with higher eradication rate compared to other regimens [OR= 4.83, 95% CI (1.49: 15.64), P-score= 0.30] and [OR= 4.32, 95% CI (1.15: 16.16), P-score= 0.36], respectively. In adults, the efficacy of QBT was higher than other stratigies in terms of H. pylori eradication [OR= 2.00, 95% CI (1.09, 3.69), P score= 0.19]. In naïve population, QBT and SQT were associated with substantial eradication rate [OR= 1.94, 95% CI (1.19: 3.16), P score=0.19] and [OR= 1.66, 95% CI (1.10: 2.50), P score=0.33], respectively. Conclusion: Our findings suggest that standard triple or sequential therapy plus another adjuvant drug, QBT and SQT therapies were the most effective regimens for eradicating H.pylori in Arab countries.

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“…When reflux reaches the pharynx, it can be defined as laryngopharyngeal reflux (LPR), which may be strongly associated with Helicobacter pylori (HP). 12 Helicobacter pylori is a gram-negative, curved or spiral-shaped, microaerophilic bacterium, and its infection is considered the main cause of active chronic gastritis, as well as plays an important role in peptic ulcer and in the genesis of gastric adenocarcinoma. 2, 13 The HP was identified in extra gastric sites such as nasal cavity, sinuses, tonsils and adenoids.…”

Section: Introductionmentioning

confidence: 99%

A Relação Entre a Patogênese Da Otite Média Efusiva E Helicobacter Pylori Em Crianças: Uma Revisão Integrativa

PEDRO¹,

VEIGA²,

TSUTIDA³

et al. 2021

Publ. Biologicas

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Objective: To discuss the role of Helicobacter pylori (HP) in the pathogenesis of otitis media with effusion (OME) in children in an integrative literature review.Method: Integrative review made in 2020 performed in the following databases: PUBMED and Biblioteca Virtual em Saúde (BVS), which includes MEDLINE, SciELO and LILACS. The descriptors "Helicobacter pylori", "Otitis Media with Effusion", "Child" and "Children" were used. It was found 66 articles, of which duplicates or without relevance to the theme were excluded, leaving 18 to full-text reading. From these, only 16 complied with the research question.Results: A total of 11 articles showed the presence of Helicobacter pylori in middle ear effusion (MEE) and/or biopsy by different methods, especially PCR, used in 12 of the 16 articles. The positivity of the samples varied between 2.9% and 70% in the analyzed studies, but only 6 of them suggested the middle ear of children with otitis media with effusion and the clinical improvement of the disease with alternative treatment for this bacterium. The other studies question the relationship ear, presence of not viable organisms for OME and non-acidic environment for HP. Conclusions:on the etiopathogenesis of otitis media with effusion.

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Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion

Abstract: H pylori infection may lead to resistance to traditional otitis media with effusion treatment in some cases. H pylori eradication is associated with a high cure rate.

Cited by 12 publications

References 19 publications

Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion

Outcome evaluation of clarithromycin, metronidazole and lansoprazole regimens in Helicobacter pylori positive or negative children with resistant otitis media with effusion

Treatment of Helicobacter pylori in the Arab world: a systematic review and network meta-analysis

A Relação Entre a Patogênese Da Otite Média Efusiva E Helicobacter Pylori Em Crianças: Uma Revisão Integrativa

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