Outcome Following Single vs Bilateral Lung Transplantation in Recipients 60 Years of Age and Older

Fischer, Stefan; Meyer, Katrin; Tessmann, R; Meyer, A.; Gohrbandt, Bernhard; Simon, Andrè; Hagl, Christian; Kallenbach, Klaus; Haverich, Axel; Strüber, Martin

doi:10.1016/j.transproceed.2004.12.269

Cited by 24 publications

(6 citation statements)

References 3 publications

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“…The survival rates of those with MDR‐KP in the one, three, six, and 12 months after transplant were as follows: 64%, 46%, 36%, and 36%, respectively. These survival rates are approximately half the one‐yr survival rates of lung transplant recipients typically reported in the literature . Survival among our cohort without KP isolation was unaffected.…”

Section: Discussionsupporting

confidence: 57%

Multidrug‐resistant Klebsiella pneumoniae acquisition in lung transplant recipients

Raviv

Shitrit

Amital

et al. 2012

Clinical Transplantation

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Section: Discussionsupporting

confidence: 57%

Multidrug‐resistant Klebsiella pneumoniae acquisition in lung transplant recipients

Raviv

Shitrit

Amital

et al. 2012

Clinical Transplantation

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“…After screening 2486 potentially eligible studies, 30 publications 6,7, involving a total of 4092 participants (1980 in the SLT group and 2112 in the BLT group) were included in this study (Figure 1). Among the included studies, 17 studies 6,13,17,19,[24][25][26]28,29,[31][32][33][34][35][36]38,39 were conducted in North America, 11 studies 8, [14][15][16]18,[21][22][23]27,30,37 were conducted in Europe, and 2 studies were conducted in other regions (South America and Oceania) 12,20 and involved individuals from multiple nations. Duplicate participants might exist among studies 17,19,24,26,32,28,31,29,34,36,33,[37][38][39] in the reference list with different primary end points.…”

Section: Search Results and Study Quality Assessmentmentioning

confidence: 99%

Bilateral Lung Transplantation Provides Better Long-term Survival and Pulmonary Function Than Single Lung Transplantation: A Systematic Review and Meta-analysis

Bian

et al. 2019

Transplantation

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Background. Both bilateral lung transplantation (BLT) and single lung transplantation (SLT) are commonly used, but which method is better remains controversial. This meta-analysis was conducted to compare the 2 surgical procedures to identify a better clinical choice. Methods. Cohort studies comparing SLT and BLT were identified by conducting searches of databases and screening references of retrieved articles. Survival, pulmonary function, surgical indicators, and complications were compared between the 2 groups. Results. Thirty studies (1980 recipients in the SLT group and 2112 recipients in the BLT group) were pooled in the meta-analysis. The long-term overall survival rate (OSR) (OSR-4y and OSR-5y), bronchiolitis obliterans syndrome (BOS)-free survival, BOS-free survival rate (BFSR) (2-5 y), 6-minute walking distance, forced expiratory volume in 1 second (%), forced vital capacity (%), oxygenation index, pulmonary arterial pressure, Arterial partial pressure of oxygen (P a o 2 ), diffusing capacity of the lung for carbon monoxide (D lco ), and BOS were better in the BLT group than in the SLT group. The advantages shown in the BLT group compared with the SLT group in regard to these variables increased with the prolongation of survival time. However, surgical time, ischemic time, postoperative intensive care unit days, and postoperative hospital days were shorter in the SLT group than in the BLT group. Overall survival, short-term OSR (1-3 y), BSFR-1y, in-hospital mortality, postoperative ventilator days, and postoperative complications (except BOS) were similar between the 2 groups. Bacterial pneumonia, graft failure, fungal infection, cardiac arrhythmia, and hemorrhage were the top 5 causes of in-hospital mortality. Conclusions. BLT appears to be associated with better long-term survival, better postoperative lung function, and less BOS compared with SLT. In-hospital mortality and postoperative complications (except BOS) were similar between the 2 groups.

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“…The choice of whether to perform single or bilateral transplant in older recipients is an area of ongoing controversy. Although bilateral transplant conveys a significant overall survival benefit for most end-stage lung diseases, association with increased early mortality compared to single lung transplant led to early recommendations to prefer single lung for recipients >65 or even >60 (1,31,32). Advances in surgical technique, ICU and post-operative care, and immunosuppression, however, began to improve survival in elderly recipients and subsequent studies in the post-LAS era have shown increased willingness to perform bilateral transplants in these patients, including those >70 © Journal of Thoracic Disease.…”

Section: Procedures Selectionmentioning

confidence: 99%

Lung transplantation in elderly patients

Courtwright

Cantu

2017

J. Thorac. Dis.

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Consensus statements on the selection of lung transplant candidates have consistently identified older age as a relative contraindication to transplantation. A combination of population-level demographic changes, revision of the lung allocation score (LAS), and clearer data on outcomes in elderly transplant recipients has, however, driven a steady increase in the threshold at which age is taken into consideration. This article reviews the current state of lung transplantation in elderly patients with an emphasis on the factors that have increased lung transplantation in older age groups, their expected outcomes including survival and health-related quality of life, and the factors that go in to appropriate candidate and procedure selection in this population.

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Outcome Following Single vs Bilateral Lung Transplantation in Recipients 60 Years of Age and Older

Cited by 24 publications

References 3 publications

Multidrug‐resistant Klebsiella pneumoniae acquisition in lung transplant recipients

Multidrug‐resistant Klebsiella pneumoniae acquisition in lung transplant recipients

Bilateral Lung Transplantation Provides Better Long-term Survival and Pulmonary Function Than Single Lung Transplantation: A Systematic Review and Meta-analysis

Lung transplantation in elderly patients

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