Outcome following surgical intervention in children with chronic inflammatory bowel diseases

El‐Baba, Mohammad; Lin, Cheng-Jui; Klein, M.; Tolia, Vasundhara

doi:10.1016/s0016-5107(05)80196-8

Cited by 11 publications

(19 citation statements)

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“…This differs from previous findings-El-Baba et al [27] demonstrated Our results could again be partly explained by the differences in preoperative characteristics of our patients-all were treated with steroids for a mean period of 6.13 months prior to surgery. This suggests patients may have developed a fallacious increase in weight prior to surgery due to chronic steroid therapy.…”

Section: Discussioncontrasting

confidence: 99%

Surgery results in significant improvement in growth in children with Crohn’s disease refractory to medical therapy

et al. 2006

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Inflammatory bowel disease (IBD) in children can cause significant impairment in linear growth, and delay in pubertal onset. The aim of this study was to assess the impact of surgery on linear growth in children with Crohn's disease (CD) who were resistant to medical therapy, and had documented evidence of growth impairment. We performed a retrospective study on eight consecutive patients with refractory disease who had attended the paediatric IBD clinic. All patients underwent surgery as part of their treatment. Height and weight were recorded at least 6 months prior to surgery, at the time of surgery, and 6 months post surgery. Growth velocities and height Z-scores were calculated. All patients had evidence of sustained growth suppression prior to surgery. Three patients had evidence of growth failure. There was a significant increase in height velocity from 0.15 cm/month before surgery to 0.54 cm/month after surgery (P = 0.006). There was also a significant decrease in the modified Harvey-Bradshaw index (HBI) of disease activity from 2.00 before surgery, to 0.84 after surgery (P = 0.003). Improvements in height Z-score and weight velocity after surgery were not significant on statistical analysis. Our study demonstrates that before surgery, children with CD refractory to therapy have sustained growth suppression, and in some cases may even have growth failure. Surgical intervention before puberty appears to result in a significant improvement in height velocity and disease activity. These findings need to be further investigated with carefully designed prospective studies.

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Section: Discussioncontrasting

confidence: 99%

Surgery results in significant improvement in growth in children with Crohn’s disease refractory to medical therapy

et al. 2006

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“…The overall incidence of postoperative complications was not significantly different between adults 1-5 and children. [7][8][9] In pediatric patients with UC, growth retardation is a serious complication which may affect them throughout their life if not treated early and properly. Therefore, surgery should be considered at an early stage in cases demonstrating growth retardation.…”

Section: Discussionmentioning

confidence: 99%

Restorative Proctocolectomy for Pediatric Patients with Ulcerative Colitis

Sako¹,

Kimura²,

Arai³

et al. 2006

Surg Today

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“…78,79 In these instances, surgery can restore normal growth, but it is optimally performed before the onset of puberty. [80][81][82][83][84] 2. Patients with symptomatic disorders of the skin, mouth, eye, or joints who fail to respond to medical therapy should be considered for operation.…”

Section: Growth Retardation and Extraintestinal Manifestationsmentioning

confidence: 99%