Outcome for Acute Lymphoblastic Leukemia Since 1975

Kirk, Judy; Stevens, Michael; Bergin, Mary; Menser, Margaret A.; Tink, Arnold

doi:10.1097/00043426-198822000-00001

Cited by 2 publications

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“…Systematic improvement in the treatment strategies of childhood acute lymphoblastic leukemia (ALL) has made it possible to achieve a remission rate greater than 90% with long-term disease-free survival and possibly cure in 50-70% of children treated [1][2][3][4]. The introduction of early intensive therapy with improved supportive care has played a major role in improving the outcome of ALL.…”

Section: Introductionmentioning

confidence: 99%

Four‐agent induction/consolidation therapy for childhood acute lymphoblastic leukemia: An Indian experience

et al. 1992

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During 1984-1986, a total of 128 children with acute lymphoblastic leukemia (ALL) were treated with an induction-consolidation regimen consisting of doxorubicin, vincristine, cytosine-arabinoside, and prednisolone. One hundred two (80%) patients belonged to high-risk group. The complete remission rate for all the patients was 91%. The event-free survival at 5 years was 32.0% +/- 23%. On multivariate analysis the event-free survival and disease-free survival was not altered by age, sex, WBC count, platelet count, LDH level, and surface phenotype. Infection due to prolonged marrow aplasia was a common complication, leading to mortality of 8 patients during induction and 33 patients during first remission. The relapse rate has been 36% (42 patients). The predominance of high-risk ALL in the Indian population underscores the need for intensive therapy. Improved supportive care during induction and remission seems essential to decrease therapy-related mortality, leading to improved survival.

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Section: Introductionmentioning

confidence: 99%

Four‐agent induction/consolidation therapy for childhood acute lymphoblastic leukemia: An Indian experience

et al. 1992

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Long-Term Cerebral Effects of CNS Chemotherapy in Children with Acute Lymphoblastic Leukemia

Bakke

Fossen

Storm-Mathiesen

et al. 1993

Pediatric Hematology and Oncology

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Fifteen 7-16-year-old patients, treated in 1981-1984 for acute lymphoblastic leukemia (ALL) in first complete remission, were studied. As a central nervous system prophylaxis, all the children were treated with repeated methotrexate (MTX) instillations, but none were irradiated. The study protocol included magnetic resonance (MR) and a battery of neuropsychological tests. Small, punctate white-matter lesions were found by MR in eight children, probably minor vascular lesions. All the children were within normal intelligence range with a mean total WISC-R IQ of 109. Minor neuropsychologic problems were found in two patients, while one child showed a more extensive specific learning disorder in school.

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Outcome for Acute Lymphoblastic Leukemia Since 1975

Cited by 2 publications

References 0 publications

Four‐agent induction/consolidation therapy for childhood acute lymphoblastic leukemia: An Indian experience

Four‐agent induction/consolidation therapy for childhood acute lymphoblastic leukemia: An Indian experience

Long-Term Cerebral Effects of CNS Chemotherapy in Children with Acute Lymphoblastic Leukemia

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