Outcome for patients with isolated atrial septal defects in the oval fossa diagnosed in infancy

Demir, Tevfik; Öztunç, Funda; Eroğlu, Ayşe Güler; Saltık, Levent; Ahunbay, Gülay; Kutluğ, Şeyhan; Güzeltaş, Alper; Altun, Gürkan

doi:10.1017/s1047951107001692

Cited by 13 publications

(13 citation statements)

References 23 publications

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“…The natural history of ASDs like those reported here was seen in previous echocardiographic evaluations, many of which showed spontaneous closure [7][8][9][10][11][12]. The rate of spontaneous closure varied, ranging from 4% [13] to 70% [10].…”

Section: Discussionsupporting

confidence: 64%

“…The strategy in our institution is that surgical repair is performed in cases with Q p /Q s > 2.0; in cases with Q p /Q s 1.5-2.0, the patient awaits the start of catheter treatment in Japan without surgical repair. Many previous reports regarding the natural history of small ASD defects described spontaneous closure [7][8][9][10][11][12]. However, defects larger than a certain threshold increase in size with age [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Natural history of medium-sized atrial septal defect in pediatric cases

Saito

Ohta

Nakayama

et al. 2012

Journal of Cardiology

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Natural history of medium-sized atrial septal defect in pediatric cases

Saito

Ohta

Nakayama

et al. 2012

Journal of Cardiology

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“…Several studies have documented that ASD can close spontaneously (naturally) without surgical intervention, depending on the anatomical type and size of the defects, as well as age of the patients [13-15]. Size of the defect is the most important predictor for spontaneous closure of ASD [14,16]. On the other hand, sinus venosus and ostium primum defects are usually associated with a haemodynamically significant shunt, do not decrease in size, and usually need surgical closure [17, 18].…”

Section: Introductionmentioning

confidence: 99%

“…Closure of moderate secundum ASDs have been reported to occur spontaneously in 4 - 14% of young patients [13,14, 16]. However, several studies have consistently documented lack of spontaneous closure of large size ASDs which most often require surgery [6,16,19]. In spite of the spontaneous closure of ASDs, some studies have also noted an increased and/or a decreased size of ASDs, over time.…”

Section: Introductionmentioning

confidence: 99%

“…In spite of the spontaneous closure of ASDs, some studies have also noted an increased and/or a decreased size of ASDs, over time. For example, in follow up studies of children with moderate to large size ASDs and remained untreated, 65 to 75% showed increased, 9 to 14% showed reduced, while 15 to 20% showed no size changes in the diameter of ASDs, as their age increased [4,14,16,19].…”

Section: Introductionmentioning

confidence: 99%

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Incidence of atrial septal defects in children attended the Cardiac Center of Ethiopia during January 2016 to December 2018

Musa

Afework

Bedru

et al. 2020

Preprint

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BackgroundAlthough it appears that an atrial septal defect (ASD) occurs frequently in Ethiopia there are only a few published studies available so far on this matter. This study is therefore aimed to evaluate the prevalence and echocardiographic characteristics of ASDs in children (aged ≤ 15 years) attended a cardiac referral center in Ethiopia.MethodsThis retrospective study reviewed the sociodemographic data and the initial echocardiographic findings of the children with ASDs who were diagnosed at the Cardiac Center of Ethiopia (CCE), Addis Ababa, from January 2016 to December 2018.ResultsA total of 116 children (56.9% females and 43.1% males) with a mean age of 3.47± 3.72 years (range: 15 days to 15 years) were diagnosed with ASDs. The most prevalent age groups were infancy (50%) and early childhood (29.3%). All the studied cases were diagnosed with ostium secundum ASD while there were no cases with ostium primum, sinus venosus and coronary sinus defects. The most frequent ostium secundum ASD was large size (61.2%) and was more frequent in infants (23.3%) and young children (21.6% of all cases).ConclusionOstium secundum ASD is the most prevalent IAS defect and more common among female cases. Large size ostium secundum ASD is more frequent in the studied children and is more prevalent in infants and young children. This survey may provide data for the currently lacking statistics on ASDs at the CCE and might be helpful for the management and follow-up of children with ASDs. Scheduled follow-up and intervention studies are required to evaluate the incidence and patterns of spontaneous and surgical closure of ASD and their outcomes.

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Natural History of Secundum ASD in Preterm and Term Neonates: A Comparative Study

Heidari,

Kumaran,

Pagano

et al. 2024

Pediatr Cardiol

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Background: Atrial septal defects(ASDs) are common in neonates. Although past studies suggest ASDs >3mm in term neonates(TN) are less likely to close, there is paucity of data regarding the natural history in preterm neonates(PN), information that would inform surveillance. We sought to compare spontaneous closure rates and need for intervention for ASDs in TN/near term (>36 weeks) versus PN (<36 weeks).Methods: We included all TN and PN who underwent echocardiography at <1 month between 2010-2018 in our institution with an ASD >3mm, without major congenital heart disease, and with repeat echocardiogram(s). Spontaneous resolution was de ned as size diminution to £3mm or closure.Results: We included 156 TN (mean gestational age at birth 38.6±1.4 weeks) and 156 PN (29.6±3.7 weeks) with a mean age at follow-up of 16±19 and 15±21 months, respectively (p=0.76). Based on largest color Doppler diameter, in TNs, ASD resolution occurred in 95% of small (3-5mm), 87% of moderate (5.1-8mm), and 60% of large (>8mm) defects; whereas, in PNs, resolution occurred in 79% of small, 76% of moderate, and 33% of large ASDs. There was a signi cant association between size and ASD resolution in TNs (p=0.003), but not PNs (p=0.17). Overall, ASD resolution rate was higher in TNs (89%) versus PNs (78%) (p=0.009), and fewer TNs (1%) compared to PNs (7%) required ASD intervention (p=0.02).Conclusion: Most ASDs identi ed in TN and PN spontaneously resolve. PN, however, demonstrate lower ASD resolution and higher intervention rates within all size groups. These data should inform follow-up of affected neonates.

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Outcome for patients with isolated atrial septal defects in the oval fossa diagnosed in infancy

Cited by 13 publications

References 23 publications

Natural history of medium-sized atrial septal defect in pediatric cases

Natural history of medium-sized atrial septal defect in pediatric cases

Incidence of atrial septal defects in children attended the Cardiac Center of Ethiopia during January 2016 to December 2018

Natural History of Secundum ASD in Preterm and Term Neonates: A Comparative Study

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