Outcome in 34 patients with juvenile‐onset mycosis fungoides

Abstract

New methodology for the stereoselective synthesis of trisubstituted olefins is presented. The use of ortho‐diphenylphosphanyl benzoate (o‐DPPB) as a directing leaving group for copper‐mediated allylic substitution with Grignard reagents allowed for the stereoselective construction of a wide range of E olefins, without the need for an adjacent electron‐withdrawing group. Our modular three‐step approach toward trisubstituted alkenes commenced with geminal α‐methylene aldehydes. Addition of an organometallic reagent and introduction of the o‐DPPB group by esterification was followed by the o‐DPPB‐directed copper‐mediated allylic substitution with a Grignard reagent to furnish stereodefined trisubstituted olefins. Additionally, incorporation of a stereocenter from the chiral pool allowed the preparation of an enantiomerically pure olefin that bore three alkyl substituents in high E/Z selectivity.

Apresentação cutânea inicial de linfomas na infância

“…Clinical progression is slow. 1,6,7 In the present sample, no cases of MF were found, which may reflect a true epidemiological variation or, more probably, a variation related to the sample population.…”

WHO-EORTC classification for cutaneous lymphomas

“…MF typically affects older adults (median age at diagnosis: 55-60 years; male-to-female ratio: 1.6-2.0:1), but may occur in children and adolescents. [47][48][49][50] MF has an indolent clinical course with slow progression over years or sometimes decades, from patches to more infiltrated plaques and eventually to tumors ( Figure 1A). In some patients, lymph nodes and visceral organs may become involved in the later stages of the disease.…”

Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo

“…In contrast to conventional mycosis fungoides, in which the neoplastic cells are CD4 þ in the vast majority of cases, 5 the neoplastic cells in hypopigmented mycosis fungoides have a CD8 þ T-cell phenotype. [6][7][8][9] The mechanism of hypomelanosis in hypopigmented mycosis fungoides is as yet unclear. Damaged melanosomes 10 and a decreased number of melanocytes 11,12 have been reported in hypopigmented mycosis fungoides lesions.…”