1998
DOI: 10.1016/s0360-3016(98)00296-x
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Outcome in elderly patients undergoing definitive surgery and radiation therapy for supratentorial glioblastoma multiforme at a tertiary care institution

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Cited by 124 publications
(75 citation statements)
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“…The standard of care currently is surgical resection combined with radiotherapy postoperatively. Mohan, et al demonstrated that radiation was of value in increasing median OS [10]. Roa, et al demonstrated that there was no statistical difference between standard radiation therapy (60 Gy in 30 fractions) or a shorter course (40Gy in 15 fractions) [11].…”
Section: Discussionmentioning
confidence: 99%
“…The standard of care currently is surgical resection combined with radiotherapy postoperatively. Mohan, et al demonstrated that radiation was of value in increasing median OS [10]. Roa, et al demonstrated that there was no statistical difference between standard radiation therapy (60 Gy in 30 fractions) or a shorter course (40Gy in 15 fractions) [11].…”
Section: Discussionmentioning
confidence: 99%
“…It has been demonstrated that gross total resection has a survival advantage compared with partial resection and certainly compared with biopsy alone. 2,3 Few studies have explored the association between age and short-term postoperative outcomes, and the reports have been conflicting. [19][20][21][22] By using samples from patients who underwent resection of both primary and metastatic tumors, 2 studies associated age with an increased risk of major complications.…”
Section: Interpretations In the Context Of The Literaturementioning
confidence: 99%
“…Fourth, we did not have data on the size, exact location, number, or type of primary lesions for patients who had metastasis (n ¼ 380); whether patients received whole-brain radiotherapy before resection; or the extent of resection, all of which have been previously identified as affecting survival. [2][3][4][5] However, postoperative complications and short-term mortality reportedly were similar between patients who underwent craniotomy for a single tumor resection versus multiple tumor resections 4 and, although it has been observed that the type of primary lesion affects overall survival, 25 no study to date has demonstrated a difference in postoperative short-term outcomes. Fifth, because there are suboptimal data on preoperative and postoperative neurologic function, these results cannot be compared against studies that only assessed neurologic function as a postoperative complication.…”
Section: Limitationsmentioning
confidence: 99%
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“…4) Several prognostic factors have been identified in patients with malignant glioma, including age, performance status, histological grade, and extent of resection. 10,13,[20][21][22][23][24][25][30][31][32][33]38) Age is considered a strong negative factor on survival. 10,[21][22][23][24][25]32,35,38) However, age should not be a reason for exclusion from aggressive treatment, 5,27,39,45) because the few investigations of the treatment of malignant gliomas in the elderly 4,10) have not defined the prognostic factors in this subgroup.…”
Section: Introductionmentioning
confidence: 99%