Outcome in Patients with H1N1 Influenza and Cerebrovascular Injury Treated with Extracorporeal Membrane Oxygenation

Chow, Felicia C.; Edlow, Brian L.; Frosch, Matthew P.; Copen, William A.; Greer, David M.

doi:10.1007/s12028-011-9534-7

Cited by 38 publications

(29 citation statements)

References 14 publications

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“…The splenial distribution of MH is consistent with the findings in two patients who suffered from H1N1 infection (16). Since both patients received venovenous ECMO, the authors attributed the MH to ECMO therapy-related complications, such as gas embolism or coagulopathy, combined with influenzarelated vascular injuries.…”

Section: Discussionsupporting

confidence: 82%

The Pattern of Brain Microhemorrhages After Severe Lung Failure Resembles the One Seen in High-Altitude Cerebral Edema

Riech

Kallenberg

Moerer

et al. 2015

Critical Care Medicine

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Section: Discussionsupporting

confidence: 82%

The Pattern of Brain Microhemorrhages After Severe Lung Failure Resembles the One Seen in High-Altitude Cerebral Edema

Riech

Kallenberg

Moerer

et al. 2015

Critical Care Medicine

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“…Other pathologies linked to a similar pattern of abnormal susceptibility foci at the cortical‐subcortical junction that have been published in the literature include an association with extracorporeal membrane oxygenation (ECMO) . In our case series, 4 of the 10 patients were on ECMO.…”

Section: Resultssupporting

confidence: 54%

Susceptibility Etching on MRI in Patients with Microangiopathy

Chang

Arani

Chew

et al. 2016

Journal of Neuroimaging

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In this preliminary case series, we describe patients with "susceptibility etching" on SWI who were also found to have profound coagulation impairment. While other comorbities may also contribute to this novel sign, we suggest that a possible etiology may be secondary to microvascular in situ formation of fine thrombi and/or emboli lodged into an area of vascular caliber reduction and maybe related to thrombotic microangiopathy.

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“…Bleeding is common in ECMO and cerebral bleeding, occurring at a rate of 4-15 %. In the majority of these patients, the outcome is deleterious [21][22][23][24][25]. Bleeding risk and transfusion requirements need to be balanced against VT/VTE risk, and this might likely end up in less anticoagulation.…”

Section: Table 3 Laboratory Measurements In Ecmo Patientsmentioning

confidence: 99%

Runtime and aPTT predict venous thrombosis and thromboembolism in patients on extracorporeal membrane oxygenation: A retrospective analysis

Trudzinski

Minko

Rapp

et al. 2016

2.1 Acute Critical Care

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Background: Even though bleeding and thromboembolic events are major complications of extracorporeal membrane oxygenation (ECMO), data on the incidence of venous thrombosis (VT) and thromboembolism (VTE) under ECMO are scarce. This study analyzes the incidence and predictors of VTE in patients treated with ECMO due to respiratory failure. Methods:Retrospective analysis of patients treated on ECMO in our center from 04/2010 to 11/2015. Patients with thromboembolic events prior to admission were excluded. Diagnosis was made by imaging in survivors and postmortem examination in deceased patients.Results: Out of 102 screened cases, 42 survivors and 21 autopsy cases [mean age 46.0 ± 14.4 years; 37 (58.7 %) males] fulfilling the above-mentioned criteria were included. Thirty-four patients (54.0 %) underwent ECMO therapy due to ARDS, and 29 patients (46.0 %) with chronic organ failure were bridged to lung transplantation. Despite systemic anticoagulation at a mean PTT of 50.6 ± 12.8 s, [VT/VTE 47.0 ± 12.3 s and no VT/VTE 53.63 ± 12.51 s (p = 0.037)], VT and/or VTE was observed in 29 cases (46.1 %). The rate of V. cava thrombosis was 15/29 (51.7 %). Diagnosis of pulmonary embolism prevailed in deceased patients [5/21 (23.8 %) vs. 2/42 (4.8 %) (p = 0.036)]. In a multivariable analysis, only aPTT and time on ECMO predicted VT/VTE. There was no difference in the incidence of clinically diagnosed VT in ECMO survivors and autopsy findings.

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Outcome in Patients with H1N1 Influenza and Cerebrovascular Injury Treated with Extracorporeal Membrane Oxygenation

Cited by 38 publications

References 14 publications

The Pattern of Brain Microhemorrhages After Severe Lung Failure Resembles the One Seen in High-Altitude Cerebral Edema

The Pattern of Brain Microhemorrhages After Severe Lung Failure Resembles the One Seen in High-Altitude Cerebral Edema

Susceptibility Etching on MRI in Patients with Microangiopathy

Runtime and aPTT predict venous thrombosis and thromboembolism in patients on extracorporeal membrane oxygenation: A retrospective analysis

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