Outcome including long-term quality of life after total pancreatectomy (PANORAMA): a nationwide cohort study

Abstract

activated. We also found that the MHC II antigen presenting pathway is downregulated in tumors. Conclusion: This study has showed that immune response is activated during PDAC, however, several evading mechanisms were simultaneously observed. Although the immune system might be activated, these mechanisms may ensure tumour cells avoid being recognized and subsequently eliminated. Thus, targeting these mechanisms might prove beneficial for the development of immunebased therapeutic strategies for PDAC treatment.Caption 1: Simultaneous enrichment of immune and signalling pathways in early pancreatic ductal adenocarcinoma patients.