Outcome of assisted reproduction

Sutcliffe, Alastair; Ludwig, Michael

doi:10.1016/s0140-6736(07)60456-5

Cited by 272 publications

(183 citation statements)

References 94 publications

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“…An increased incidence of malformations and chromosomal anomalies was reported especially when the reason for performing ART was severe male factor infertility. 81,82 Apart from the above mentioned health consequences of the offspring fathered by a man with severe spermatogenic failure, there is still very little known about the long term health condition of both the infertile man and of his offspring.…”

Section: Discussionmentioning

confidence: 99%

Male infertility: Pathogenesis and clinical diagnosis

Krausz¹

2011

Best Practice & Research Clinical Endocrinology & Metab

420

315

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Section: Discussionmentioning

confidence: 99%

Male infertility: Pathogenesis and clinical diagnosis

Krausz¹

2011

Best Practice & Research Clinical Endocrinology & Metab

420

315

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“…4,14 It has been interesting to see over the years that most studies comparing ICSI with in vitro fertilisation (IVF) generally report no increased risks associated with ICSI over and above those associated with IVF in any particular outcomes for the offspring. [15][16][17][18][19] There has been a recent study from Norway reporting that ICSI pregnancies have a lower risk of iatrogenic moderate preterm delivery, than IVF pregnancies. 20 Although the preterm IVF pregnancies (8.6% overall) had more congenital malformations than ICSI and may have contributed to the obstetric intervention (14% compared with 9.6%), there is no convincing reason for this.…”

Section: Introductionmentioning

confidence: 99%

Outcomes for offspring of men having ICSI for male factor infertility

Halliday¹

2011

Asian J Androl

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Since the introduction of intracytoplasmic sperm injection (ICSI) using single sperm isolated from testicular tissue in men with obstructive and non-obstructive azoospermia, or using ejaculated sperm in those with poor semen quality, there have been concerns that this might have adverse effects on the offspring compared to conventional in vitro fertilisation (IVF) and natural conceptions. ICSI is done for reasons other than male factor infertility, and on the whole has not been shown to have any more negative effects than those seen with IVF. There have however, been very few studies of ICSI with a focus on, or large enough numbers to examine, the specific outcomes associated with male factor infertility. From the limited information available in relation to the source of the sperm and aetiology of infertility in the presence of ICSI, there appears to be no increased risk of congenital malformations. There is, however, a small increase in both de novo and inherited chromosome abnormalities. In terms of growth and neurodevelopment, there are very few studies, and so far, no adverse outcomes have been found in young children whose fathers have a sperm defect. The origin of the sperm used in ICSI does not have a major influence on the early life outcomes for the offspring, but transgenerational and epigenetic effects remain unknown. When the male factor infertility is known or thought to be due to a Y-chromosome deletion, this information should be given to the young male offspring at a time that will ensure his own reproductive health and plans are optimized.

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“…Children from pregnancies occurring, either spontaneously or induced, after a period of subfertility, are also at higher risk of congenital malformations [32]. Chung et al [33] found no effect of etiology of subfertility, dose or type of medication used for stimulation, use of embryo-manipulation techniques, or embryo quality on perinatal outcome [33].…”

Section: Congenital Malformationsmentioning

confidence: 99%

“…ART has brought a child to literally hundreds of thousands of couples who would otherwise not have conceived; it is now estimated that up to 4 % of all births in developed nations involve ART [32]. The oldest ART offspring are entering adult life.…”

Section: International Registry Of Art Babiesmentioning

confidence: 99%

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

Albertini

Evers²,

Geraedts³

et al. 2014

J Assist Reprod Genet

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Purpose Assisted Reproduction Treatment (ART) is here to stay. This review addresses the parental background of birth defects, before, during and after conception and focuses both on the underlying subfertility and on the question whether ART as a treatment is an additional contributing factor. Methods Searches were performed in Medline and other databases. Summaries were discussed in a Delphi panel set-up by the European Society of Human Reproduction and Embryology (ESHRE). Results Several birth defects and adult diseases arise during the earliest stages of ovarian development and oocyte differentiation: this is the case of cleft palate disorders in offspring from female rat exposed to Dioxin during fetal life or the polycystic ovary diseases in female offspring (primates) exposed to elevated androgen concentration during fetal life. Human oocytes and embryos often fail to stop the propagation of aneuploid cells but maintain their ability to repair DNA damages including those introduced by the fertilizing sperm. There is a 29 % increased risk of birth defects in the newborns spontaneously conceived by subfertile couples and the risk is further increased (34 %) when conception is achieved by treating infertlity with ART (Danish IVF Registry). Periconceptional conditions are critical for ART babies: their birth weight is in general smaller (Norvegian Registry) but a more prolonged culture time doubled the number of large babies (Finnish Registry). Conclusion The long-term developmental effects of ART on child and subsequent health as an adult remains a subject worthy of futher monitoring and investigation. Capsule Remaining mindful of the growing body of evidence showing that during gamete production, genetic and epigenetic changes influence offspring health, serves to reinforce the need to continue to monitor ART children.

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Outcome of assisted reproduction

Cited by 272 publications

References 94 publications

Male infertility: Pathogenesis and clinical diagnosis

Male infertility: Pathogenesis and clinical diagnosis

Outcomes for offspring of men having ICSI for male factor infertility

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

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