Outcome of axonal and demyelinating forms of Guillain-Barré syndrome in children

Prospective study on anti-ganglioside antibodies in childhood Guillain-Barre syndrome

“…2 28 A large number of cases with C jejuni-associated GBS and AMAN have also been reported in children from China, South America, Turkey and South Africa. [29][30][31][32][33] However, this organism does not seem to occur so frequently as an aetiological agent in Abs, antibodies; GBS, Guillain-Barré syndrome; IQR, interquartile range; max, maximum; NCS, nerve condition study; RTI, respiratory tract infection. The one child with monospecific anti-GT1a IgG had an especially severe course of GBS with ocular and bulbar involvement, associated with a recent C jejuni gastroenteritis.…”

Guillain-Barré syndrome: Clinical profile and Consensus to revise Hughes grade 5

“…This is comparable to previous studies. 10,11,13,20 Early arrival (<1 week) to hospital, initiation of intravenous Immunoglobulin and intensive care helped to achieve complete recovery in our study. Axonal form of GBS recovered more slowly than those with demyelinating form but outcome at 12 months appear to be equally favorable in two groups.…”

“…10,11,15 Overall preponderance (51.2%) was noted in axonal forms (AMAN+ AMSAN) of GBS. Tekqul H et al 20 reported similar findings in children. We found that on comparing demyelinating (AIDP) and axonal (AMAN+AMSAN) forms of GBS, mean age was …”

“…Similar finding were reported by Bhargava et al 10 Mean CSF protein was 80.27mg/dl and is comparable to studies by Chio et al 21 and Corston et al 22 Mortality in GBS is associated with respiratory failure requiring mechanical ventilation that prolongs hospital stay. To detect early respiratory failure, all cases with Hughes grade 4 and those with MRC sum score suggestive of moderate (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) and severe (0-10) motor deficit were assessed intensively for early respiratory failure. Battery of tests included were baseline measurement of peripheral saturation (Sao2), single breath count (SBC), peak expiratory flow meter and dysphagia tests.…”

To Study The Indicators For Severe Course of Guillain- Barre Syndrome

“…The fact that those of our patients with history of acute gastroenteritis took significantly longer to recover and begin walking aided/unaided can be attributed to them having the AMAN subtype. [15] Mortality was higher in patients with GI symptoms (40%) &AMAN (25%) as compare to respiratory infection (20%) &AIDP (17.8%).Mortality was higher in patient who had speech impairment associated with bulbar palsy (5/9,55.5%) as compare to autonomic disturbance (6/13,46%). Mortality was higher in patients who had rapid progression of weakness within 24 hours involving all four limbs, speech impairment and with autonomic disturbance at the time of admission.…”