Outcome of cataract surgery in children with Down syndrome

Saifee, Murtaza; Kong, Lingkun; Yen, Kimberly G.

doi:10.1016/j.jaapos.2016.07.161

Cited by 3 publications

(6 citation statements)

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“…Children with Down syndrome have a greater risk of ocular abnormalities such as congenital cataracts. [ 5 ]…”

Section: Introductionmentioning

confidence: 99%

“…Children with Down syndrome have a greater risk of ocular abnormalities such as congenital cataracts. [5] Control of childhood blindness is a priority of the World Health Organization global proposal to eradicate avoidable blindness. Due to the development of sequencing technology and stem cell research, congenital cataract screening, and treatment have rapidly improved in the past decade.…”

Section: Introductionmentioning

confidence: 99%

“…Down syndrome is a common chromosomal disorder of chromosome 21, causes mental disability and delayed growth. Children with Down syndrome have a greater risk of ocular abnormalities such as congenital cataracts [5] …”

Section: Introductionmentioning

confidence: 99%

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Mapping of global research output in congenital cataracts from 1903 to 2021

et al. 2021

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Background and aim: Globally, congenital cataract remains one of the main causes of visual loss in children. This study was designed to plot the overall research output and evaluate some key bibliometric indicators in congenital cataracts research. Methods: Publications on congenital cataracts were retrieved from the Web of Science Core Collection database. The published literature was searched using the keywords “congenital cataract” OR “congenital cataracts” in the title filed with document types and language restrictions. The data were exported into HistCite to analyze; publication year, top authors, countries, institutions, journals, keywords, and most cited studies. VOSviewer software was used to construct network visualization mapping. Results: A total of 1427 publications (1903–2021) published in English language were included in this study. Over the past few decades, the total number of publications in congenital cataracts was found to be increased. The most productive year was 2016 (n = 72), while the most cited year was 1941 (1268 citations). The Investigative Ophthalmology & Visual Science (Impact Factor: 4.799) was the most attractive journal with 161 publications, and the Molecular Vision (Impact Factor : 2.367) was the most cited journal with 1915 citations and 161.723 citations per year. The most productive country was the United States of America (USA) (n = 325), while the most active institute was Sun Yat-sen University, China (n = 36). The most prolific author was Yao K (n = 27). The most studied Web of Science category was ophthalmology (n = 852). The most widely used keyword was congenital (n = 1427). The most cited paper in congenital cataracts was “Congenital cataract following German measles in the mother, cited 1268 times. The USA and author keyword congenital cataract had the highest total link strength. Conclusion: These findings provide useful insights, current status, and trends in clinical research in congenital cataracts. This study can be used to identify future research areas and standard bibliography references for better diagnosis and disease control.

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“…Children with Down syndrome have a greater risk of ocular abnormalities such as congenital cataracts. [ 5 ]…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mapping of global research output in congenital cataracts from 1903 to 2021

et al. 2021

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“…With regard to surgical outcomes, Saifee et al 117 previously examined a series of 19 eyes which underwent cataract surgery in a pediatric Down syndrome population and concluded that the rate of post-operative complications was comparable to that of cataract surgery in the general pediatric population. Gardiner et al 118 examined a series of 471 pediatric eyes undergoing cataract extraction and found that 33 (7.0%) were from patients with Down syndrome; of these, 5 (15.2%) developed aphakic glaucoma, 10 (30.0%) developed posterior capsular opacification (PCO), 2 (6.0%) developed retinal detachments (RDs), and 1 (3.0%) resulted in an enucleation.…”

Section: Cataractsmentioning

confidence: 99%

“…Limited studies have examined cataracts in adults with Down syndrome. Although the type of cataract was not discussed, Puri et al 111 examined 68 adult subjects aged 28-84 and found that 16% had cataracts; furthermore, they found that the prevalence of cataracts in patients aged 45-64 was greater than that of the general population but was equivalent in patients aged 65-75. With regard to surgical outcomes, Saifee et al 117 previously examined a series of 19 eyes which underwent cataract surgery in a pediatric Down syndrome population and concluded that the rate of post-operative complications was comparable to that of cataract surgery in the general pediatric population. Gardiner et al 118 examined a series of 471 pediatric eyes undergoing cataract extraction and found that 33 (7.0%) were from patients with Down syndrome; of these, 5 (15.2%) developed aphakic glaucoma, 10 (30.0%) developed posterior capsular opacification (PCO), 2 (6.0%) developed retinal detachments (RDs), and 1 (3.0%) resulted in an enucleation.…”

Section: Cataractsmentioning

confidence: 99%

Down syndrome: a review of ocular manifestations

et al. 2022

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Down syndrome is the most common genetically mediated intellectual disability. Although many physiologic and pathologic features of Down syndrome are discussed at length in the literature, the ocular manifestations of Down syndrome have seldom been discussed in a comprehensive fashion. Given that Down syndrome has ocular manifestations from the front to the back of the eye, it is important for physicians to become familiar with these manifestations, especially given the prevalence of Down syndrome. This review aims to discuss the varied ophthalmologic manifestations of Down syndrome – including strabismus, amblyopia, nystagmus, accommodation deficits, nasolacrimal duct obstruction, keratoconus, optic nerve pathology, neoplastic disease, and retinal pathology – to facilitate better care and visual outcomes in this important patient population.

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