Outcome of Childhood Acute Promyelocytic Leukemia With All-Trans-Retinoic Acid and Chemotherapy

Abstract

ATRA combined with CT for induction and also probably for maintenance provides as favorable results in children with APL as in adults and currently constitutes the reference first-line treatment in both age groups.

Outcome of acute promyelocytic leukemia treated with all trans retinoic acid and chemotherapy in elderly patients: the European group experience

“…[1][2][3][4][5][6] In children, we recently showed that, with ATRA and combination chemotherapy, the outcome of APL was similar to that of adult APL. 7 The incidence of patients aged more than 60 and 70 years ranged from 15-20 and 1-6%, respectively, in published APL series. [2][3][4][5][6] To our knowledge, two studies have specifically analyzed the impact of ATRA on the outcome of elderly APL patients.…”

High Pseudotumor Cerebri Incidence in Tretinoin and Arsenic Treated Acute Promyelocytic Leukemia and the Role of Topiramate After Acetazolamide Failure

“…PTC secondary to ATRA administration for APL has been well described in the literature through case reports in both the pediatric and young adult populations [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] and, among adults, has been most often associated with obese women of childbearing age [34]. However, all patients described in this report were males with a wide age range and body mass indexes (BMIs) consistent with an overweight (BMI 25.0-29.9 kg/m 2 ) or obese (BMI Z30 kg/m 2 ) stature.…”

“…PTC following ATRA administration for APL has been well described [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. However, reports of PTC resulting specifically from dual differentiation therapy are currently lacking, and there is a paucity of evidence describing management of this condition specifically in patients with APL, where continuation of therapy is necessary for optimal clinical outcomes.…”

Identification of PML/RARα fusion gene transcripts that showed no t(15;17) with conventional karyotyping and fluorescent in situ hybridization

“…Several studies have shown that t(15;17) is not detected by conventional cytogenetic analysis in 10% of APL cases; however, the majority of cases showing morphological APL, but lacking t(15;17), remain associated with the formation of the PML/RARα fusion gene (Stone and Mayer, 1990;Hiorns et al, 1994;Zaccaria et al, 2002;Oh et al, 2003;de Botton et al, 2004;Owatari et al, 2007). The main reason is either the presence of cryptic insertion events or complex rearrangements leading to PML/RARα fusion (Hiorns et al, 1994).…”