Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block

Jaeggi, Edgard; Hamilton, Robert M.; Silverman, Earl D.; Zamora, Samuel Antonio; Hornberger, Lisa K.

doi:10.1016/s0735-1097(01)01697-7

Cited by 363 publications

(112 citation statements)

References 25 publications

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“…Fetal Bradyarrhythmia With CHD was not a risk factor. 20, 21 Our previous study of fetal complete AVB without CHD also showed that the fetal ventricular heart rate was not associated with prognosis. 7 In contrast, our current study revealed that the ventricular heart rate was related to the outcome in fetuses with bradyarrhythmia with CHD.…”

Section: Pmi In the Neonatal Periodmentioning

confidence: 94%

“…22-25 High intrauterine mortality in cases of left atrial isomerism with complete AVB is often preceded by development of heart failure. 20, 21 A high incidence of poor cardiac function and hydrops may partially explain the poor prognosis. We suggest that myocardial dysfunction could be ascribed to bradycardia and intrinsic ventricular dysfunction proceeding from the CHD.…”

Section: Pmi In the Neonatal Periodmentioning

confidence: 99%

See 1 more Smart Citation

Fetal Bradyarrhythmia Associated With Congenital Heart Defects　– Nationwide Survey in Japan –

Miyoshi

Maeno

Sago

et al. 2015

Circ J

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Section: Pmi In the Neonatal Periodmentioning

confidence: 94%

Section: Pmi In the Neonatal Periodmentioning

confidence: 99%

Fetal Bradyarrhythmia Associated With Congenital Heart Defects　– Nationwide Survey in Japan –

Miyoshi

Maeno

Sago

et al. 2015

Circ J

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“…Related to treatment of bradyarrhythmias, early treatment of fetuses affected by atrioventricular delayed conduction or complete heart block with maternally administered dexamethasone or ritodrine may improve or prevent the loss of atrioventricular nodal conduction [88,89]. The treatment of fetal tachycardia remains controversial.…”

Section: Fetal Arrhythmiasmentioning

confidence: 99%

Latest advances in fetal echocardiography

Comas¹

2005

The Ultrasound Review of Obstetrics & Gynecology

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Cardiac anomalies are the most commonly overlooked defects in prenatal ultrasound assessment. The issue of missed prenatal diagnosis is disturbing, particularly when it occurs against a background of tremendous skill and technologic support. New policies to minimize mistakes in this critical aspect need to reach a consensus. Recent new strategies should be put in place in a multidisciplinary manner if they are to have a significant clinical impact. Particularly relevant are the strategies to improve prenatal diagnosis of congenital heart defects, to advance gestational age at diagnosis, to identify new prenatal markers of heart defects and to incorporate new tools in the field of fetal echocardiography. As a result of these advances, the prenatal detection and diagnosis of coronary heart disease has developed an increasing impact on the perinatal outcome of pregnancies complicated by fetal heart disease. We review some of the recent developments in this multidisciplinary area.

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“…31 Cases were diagnosed from fetal life through childhood. There were a total of 102 cases, divided into three groups.…”

Section: Classification and Progression Of Heart Blockmentioning

confidence: 99%

Neonatal lupus syndromes

Buyon

Rupel

Clancy

2004

Lupus

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The neonatal lupus syndromes (NLS), while quite rare, carry significant mortality and morbidity in cases of cardiac manifestations. Although anti-SSA/Ro-SSB/La antibodies are detected in > 85% of mothers whose fetuses are identified with congenital heart block (CHB) in a structurally normal heart, when clinicians applied this testing to their pregnant patients, the risk for a woman with the candidate antibodies to have a child with CHB was at or below 1 in 50. While the precise pathogenic mechanism of antibody-mediated injury remains unknown, it is clear that the antibodies alone are insufficient to cause disease and fetal factors are likely contributory. In vivo and in vitro evidence supports a pathologic cascade involving apoptosis of cardiocytes, surface translocation of Ro and La antigens, binding of maternal autoantibodies, secretion of profibrosing factors (e.g., TGFbeta) from the scavenging macrophages and modulation of cardiac fibroblasts to a myofibroflast scarring phenotype. The spectrum of cardiac abnormalities continues to expand, with varying degrees of block identified in utero and reports of late onset cardiomyopathy (some of which display endocardial fibroelastosis). Moreover, there is now clear documentation that incomplete blocks (including those improving in utero with dexamethasone) can progress postnatally, despite the clearance of the maternal antibodies from the neonatal circulation. Better echocardiographic measurements which identify first degree block in utero may be the optimal means of approaching pregnant women at risk. Prophylactic therapies, including treatment with intravenous immunoglobulin, await larger trials. In order to achieve advances at both the bench and bedside, national research registries established in the US and Canada are critical.

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Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block

Cited by 363 publications

References 25 publications

Fetal Bradyarrhythmia Associated With Congenital Heart Defects　– Nationwide Survey in Japan –

Fetal Bradyarrhythmia Associated With Congenital Heart Defects　– Nationwide Survey in Japan –

Latest advances in fetal echocardiography

Neonatal lupus syndromes

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Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block

Cited by 363 publications

References 25 publications

Fetal Bradyarrhythmia Associated With Congenital Heart Defects – Nationwide Survey in Japan –

Fetal Bradyarrhythmia Associated With Congenital Heart Defects – Nationwide Survey in Japan –

Latest advances in fetal echocardiography

Neonatal lupus syndromes

Contact Info

Product

Resources

About

Fetal Bradyarrhythmia Associated With Congenital Heart Defects　– Nationwide Survey in Japan –

Fetal Bradyarrhythmia Associated With Congenital Heart Defects　– Nationwide Survey in Japan –