Outcome of Conservatively Treated Microinvasive Squamous Cell Carcinoma of the Uterine Cervix During a 10-Year Follow-up

Abstract

A close, long-term surveillance should be scheduled for the MIC patients conservatively treated. Cone margin involvement, LVSI, and the number of quadrants involved on colposcopy are independent risk factors for disease persistence and/or progression to SCC.

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

“…Nevertheless, some have adopted the presence of LVI, or ''extensive'' LVI, as an exclusion criterion for conservative management [105,110,111,134]. In contrast, there is an increased prevalence of both lymph node metastases and recurrence after local excision in FIGO IA2, and many studies conclude that local excision alone is inadequate for this group of patients [39,103,118,126,128,130,[134][135][136][137][138].…”

“…Persistent or recurrent cervical disease may occur in women with negative margins or those involved by SIL, and both groups remain at risk for persistent or recurrent SIL [98]. Women with involved margins are at increased risk for both the presence of multifocal invasive squamous carcinoma and persistent SIL [96,137,[139][140][141][142][143]. Clinical follow-up or immediate reexcision may be chosen in the management of women with SIL at the surgical margins.…”

Analysis of Conservative Surgical Treatment and Prognosis of Microinvasive Squamous Cell Carcinoma of the Cervix Stage IA1

“…11Y13 Treatment plan for MIC without LVSI should also consider the risk of invasive disease in the residual cervix and risk of recurrence, and the most important parameters to define treatment extension and prognosis in those cases are depth of stromal invasion, conization margin involvement, and residual disease after cervical conization. 9,14Y16 Although it has been suggested by several retrospective studies that MIC has excellent prognosis and less radical surgery could be considered for these cases, 3,8,9,16 data regarding the risk and extent of residual disease in these settings are not uniform at this time. In the present study, we report a cohort of 139 women with MIC without LVSI treated conservatively or not and followed up to 20 years to explore appropriate treatment modality and analyze the prognosis and risk factors for recurrence.…”

The Grading of Lymphovascular Space Invasion in Epithelial Ovarian Carcinoma

“…6 A strong association has been found between the presence of LVSI and lymph node metastasis, as well as between postoperative recurrence and tumor-related death. 7 However, little research has been conducted to ascertain the prognostic value of LVSI in patients with ovarian cancer.…”