Outcome of COVID-19 infection in people with diabetes mellitus or obesity in the primary care setting in Catalonia, Spain: A retrospective cohort study of the initial three waves

ObjectivesThe main objective of this study was to investigate the effects of nutritional support on mortality in hospitalised patients with diabetes and nutritional risk participating in theEffect of early nutritional support on Frailty, Functional Outcomes, and Recovery of malnourished medical inpatients Trial(EFFORT) trial.DesignSecondary analysis of a Swiss-wide multicentre, randomised controlled trial.ParticipantsPatients with diabetes and risk for malnutrition.InterventionsIndividualised nutritional support versus usual care.Primary outcome measure30-day all-cause mortality.ResultsOf the 2028 patients included in the original trial, 445 patients were diagnosed with diabetes and included in this analysis. In terms of efficacy of nutritional therapy, there was a 25% lower risk for mortality in patients with diabetes receiving nutritional support compared with controls (7% vs 10%, adjusted HR 0.75 (95% CI 0.39 to 1.43)), a finding that was not statistically significant but similar to the overall trial effects with no evidence of interaction (p=0.92). Regarding safety of nutritional therapy, there was no increase in diabetes-specific complications associated with nutritional support, particularly there was no increase in risk for hyperglycaemia (adjusted OR 0.97, 95% CI 0.56 to 1.67 p=0.90).ConclusionPatients with diabetes and malnutrition in the hospital setting have a particularly high risk for adverse outcomes and mortality. Individualised nutritional support reduced mortality in this secondary analysis of a randomized trial, but this effect was not significant calling for further large-scale trials in this vhighly ulnerable patient population.Trial registration numberNCT02517476.

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Outcome of COVID-19 infection in people with diabetes mellitus or obesity in the primary care setting in Catalonia, Spain: A retrospective cohort study of the initial three waves

Cited by 2 publications

References 40 publications

A Critical Review on the Long-Term COVID-19 Impacts on Patients With Diabetes

A Critical Review on the Long-Term COVID-19 Impacts on Patients With Diabetes

Nutritional support in hospitalised patients with diabetes and risk for malnutrition: a secondary analysis of an investigator-initiated, Swiss, randomised controlled multicentre trial

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