Outcome of definitive fractionated radiation followed by exenteration of the nasal cavity in dogs with sinonasal neoplasia: 16 cases

Bowles, Kristina D.; DeSandre-Robinson, Dana M.; Kubicek, Lyndsay; Lurie, D. M.; Milner, Rowan J.; Boston, Sarah E.

doi:10.1111/vco.12115

Cited by 18 publications

(15 citation statements)

References 15 publications

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“…The results indicate a significant statistical difference in the volume reduction of carcinomas compared with sarcomas in the time frame studied. Due to the fact that tumor recurrence is the leading cause of treatment failure the recommendation of surgical cytoreduction is a logical option to slow tumor re-growth [ 10 , 12 ]. Two patients diagnosed with nasal sarcoma displayed tumor growth despite radiation therapy, suggesting not all nasal sarcomas are radiation sensitive at the doses used and the time frame studied.…”

Section: Main Textmentioning

confidence: 99%

Evaluation of tumor volume reduction of nasal carcinomas versus sarcomas in dogs treated with definitive fractionated megavoltage radiation: 15 cases (2010–2016)

2018

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ObjectiveLocal control is a major challenge in treating canine nasal tumors, and cytoreduction following radiation therapy has been recommended to extend survival and to delay local recurrence. Our objective was to compare the effect of definitive radiotherapy on the tumor volume of intranasal carcinomas compared to sarcomas. We evaluated 15 dogs that received radiotherapy within 1 month of initial CT scan, and post radiation CT scans performed within 3 months of completing full course definitive megavoltage radiation. Tumor reduction volume based on CT scans were obtained and compared between carcinoma and sarcoma groups.ResultsThe following tumor types were treated; carcinoma (8/15), sarcoma (7/15). The mean nasal tumor size before radiation therapy was 24.5 cm3 and tumor size after radiation therapy was 13.5 cm3 resulting in a mean reduction of 55.1% reduction in tumor size for both carcinomas and sarcomas. The carcinoma group displayed a volume reduction of 67.1% (SD ± 16.9) and the sarcoma group displayed a volume reduction of 21.3% (SD ± 39.7). Within the study period carcinomas were more responsive in the reduction of volume than sarcomas with fractionated megavoltage radiation.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3190-3) contains supplementary material, which is available to authorized users.

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Section: Main Textmentioning

confidence: 99%

Evaluation of tumor volume reduction of nasal carcinomas versus sarcomas in dogs treated with definitive fractionated megavoltage radiation: 15 cases (2010–2016)

2018

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“…delivered 18 to 20, 3 Gy fractions to a total dose of 48 to 54 Gy and then went to surgery 8 to 12 weeks after RT was completed (Bowles et al . 2016). The MST for all dogs analysed was 457 days, which is similar to what has been reported with RT alone (Adams et al .…”

Section: Neoadjuvant Radiation Therapy Backgroundmentioning

confidence: 99%

Neoadjuvant chemotherapy and radiation therapy in veterinary cancer treatment: a review

Wustefeld‐Janssens

Smith

Wilson-Robles

2020

J of Small Animal Practice

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Multi‐modality treatment strategies are more becoming commonplace in veterinary oncology practice yet the evidence base is far inferior to what has been generated in people. Surgery is unquestionably the cornerstone of most solid tumour treatment plans but certain scenarios dictate combining surgery with systemic chemotherapy and radiation therapy as an adjunct. By using these in the neoadjuvant setting, one can leverage certain effects of the treatment to improve local disease control, improve overall survival, gain insight into drug efficacy, reduce surgical morbidity and reduce long‐term complications. An unintended consequence of combining therapies is an increased flow of information between members of the care team upfront that in almost all cases leads to improved patient outcomes albeit a difficult metric to quantify. This review sets out to explore some of the principles of neoadjuvant therapies and discuss potential opportunities to expand the evidence base in veterinary medicine.

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“…However, most dogs die or are euthanased as a result of local disease progression even with radiation treatment 1. To improve local control, full course preoperative radiotherapy followed by surgical exenteration of the residual disease can be considered1 2; however, this protocol remains controversial 3 4…”

Section: Introductionmentioning

confidence: 99%

Preoperative radiotherapy and acridine orange photodynamic therapy causing pneumocephalus in a dog

Maruo

Nishiyama

Yokoyama

et al. 2019

Vet Record Case Reports

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The authors present a rare case of treatment complications in a 12-year-old spayed female Shiba Inu with left nasal transitional cell carcinoma. To control the tumour, the authors performed hypofractionated radiotherapy for five fractions over 1 week, combined with surgery, acridine orange photodynamic therapy (AO-PDT) and cribriform irradiation, one month after the initial radiotherapy. Six months later, the dog presented with neurological abnormalities (circling, pacing and reduced consciousness). Pneumocephalus was diagnosed. The irradiated left side of the olfactory bulb had become necrotic; therefore, surgery was performed to close the hole of the cribriform plate. Two years later, no visible radiation side effects or clinical signs related to intranasal tumour recurrence were detected. This case suggests that hypofractionated radiotherapy followed by surgery, AO-PDT and cribriform irradiation can contribute to tumour control. However, rare side effects, such as pneumocephalus, should be considered. Therefore, patients should be monitored carefully for adverse events after this combination.

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Outcome of definitive fractionated radiation followed by exenteration of the nasal cavity in dogs with sinonasal neoplasia: 16 cases

Cited by 18 publications

References 15 publications

Evaluation of tumor volume reduction of nasal carcinomas versus sarcomas in dogs treated with definitive fractionated megavoltage radiation: 15 cases (2010–2016)

Evaluation of tumor volume reduction of nasal carcinomas versus sarcomas in dogs treated with definitive fractionated megavoltage radiation: 15 cases (2010–2016)

Neoadjuvant chemotherapy and radiation therapy in veterinary cancer treatment: a review

Preoperative radiotherapy and acridine orange photodynamic therapy causing pneumocephalus in a dog

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