Outcome of different treatments for chronic diffuse sclerosing osteomyelitis of the mandible: a systematic review of published papers

Meent, Marieke M. van de; Pichardo, Sarina E.C.; Appelman‐Dijkstra, Natasha M.; Merkesteyn, J.P.R. van

doi:10.1016/j.bjoms.2020.01.012

Cited by 21 publications

(24 citation statements)

References 53 publications

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“…Hyperbaric oxygen therapy has been proposed as an alternative treatment option in therapy-resistant cases. Still, controversies in international literature and the lack of high-quality clinical studies question its use [ 2 , 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Ablative surgery, from local decortication to continuity defects of the jaw, is considered the definitive treatment modality in several cases where systemic antibiotics are limited in success. But those interventions can be disfiguring, resulting in loss of chewing function and life quality and sometimes demanding jaw microvascular or alloplastic reconstruction [ 2 , 3 ]. In refractory cases, hyperbaric oxygen therapy has been advocated; however, evidence is scarce [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…But those interventions can be disfiguring, resulting in loss of chewing function and life quality and sometimes demanding jaw microvascular or alloplastic reconstruction [ 2 , 3 ]. In refractory cases, hyperbaric oxygen therapy has been advocated; however, evidence is scarce [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Bisphosphonate therapy has been described as a successful treatment modality in primary, also called nonbacterial osteomyelitis of the jaw [ 3 ]. Since nonbacterial osteomyelitis is an autoinflammatory disease, first-line treatment consists of nonsteroidal anti-inflammatory drugs (NSAIDs), alone or combined with steroid therapy.…”

Section: Introductionmentioning

confidence: 99%

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Bisphosphonate-treatment of secondary chronic osteomyelitis of the jaw – a case report

Heimes

Kämmerer

2023

Journal of Surgical Case Reports

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Secondary chronic osteomyelitis (SCO) is caused by bacterial infection leading to progressive jawbone destruction. Antibiotics are used as first-line treatment; surgical therapy is usually extensive and may not provide a cure. Bisphosphonates have been reported to be successful in patients with primary nonbacterial osteomyelitis, and literature indicates promising results in SCO. A 38-year-old patient presented with a progressive mandible-destruction 17 years after wisdom tooth extraction. Several treatment attempts have been unsuccessful. Seeking a second opinion, the patient was then interdisciplinary treated with 90 mg of intravenous pamidronate every four weeks, three times. The patient did not experience side effects presenting a considerable improvement in mouth opening and reporting a dissolvent of signs of pain or infection. The MRI showed edema reduction and decreased contrast uptake. Therefore, bisphosphonate treatment of secondary chronic osteomyelitis of the jaw is a safe and effective option in selected cases after unsuccessful first- and second-line therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bisphosphonate-treatment of secondary chronic osteomyelitis of the jaw – a case report

Heimes

Kämmerer

2023

Journal of Surgical Case Reports

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“…Other cited treatment options include antibiotics, anti-inflammatory drugs, muscle relaxants, antiresorptive medications (bisphosphonates), conservative therapy (occlusal splint, physiotherapy), hyperbaric oxygen treatment and surgery. The most promising results seem to originate from conservative treatment options, even if the studies overall have low quality and include a limited amount of patients [21].…”

Section: Discussionmentioning

confidence: 99%

An Orthodontic Approach for Garre’s Sclerosing Osteomyelitis of the Mandible

Barbur

Bran

Băciuţ

et al. 2021

IJERPH

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The nonsuppurative osteomyelitis of the mandible is a rare condition that can occur in children due to low-grade inflammatory processes, dental cavities, periodontal lesions as well as the eruption process of the teeth. We submit a case report involving the orthodontic management of a 9-year-old female patient who presented in our service in the mixed dentition period with diagnosed Garre’s sclerosing osteomyelitis of the entire mandibular body. After a full work-up, the following symptoms and signs were noted: bilateral temporomandibular joint (TMJ) pain, loss of the leeway space, anterior open bite, distalization of the secondary maxillary right canine, nail biting and tongue thrust. Our orthodontic objectives were to relieve the TMJ pain, limit the eruption process of the teeth and to diminish the evolution of the osteomyelitis, reduce the growth of the inferior lower third of the face and to prevent further invasive treatment of the patient. In the first phase of treatment, we established a centric relationship using an orthopedic appliance (occlusal splint) and physiotherapy to deprogram the muscles and the TMJ. Throughout the second phase of treatment, we used orthopedic appliances to inhibit the overeruption of the secondary molars. After another year of treatment, the osteomyelitis lesions were under control with the permanent teeth in final position, good facial esthetic and as a functional result, no root resorption. We can conclude that by using low physiological forces to direct and control the growth pattern, good results could be obtained in stabilizing and controlling the sclerosing osteomyelitis of the mandible.

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