Outcome of Extremely Low Birth Weight Infants (500 to 999 Grams) Over a 12-Year Period

Piecuch, Robert E.; Leonard, Carol H.; Cooper, Bruce A.; Sehring, Sally

doi:10.1542/peds.100.4.633

Cited by 156 publications

(73 citation statements)

References 14 publications

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“…[35][36][37][38] These findings are somewhat reassuring in that we did not see differences in neurologic or cognitive outcome related to rHuEPO treatment. However, the size of the sample was not large enough to detect with certainty an adverse effect that is rare.…”

Section: Discussionsupporting

confidence: 54%

Neurodevelopmental Outcome of Prematurely Born Children Treated With Recombinant Human Erythropoietin in Infancy

et al. 1999

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Section: Discussionsupporting

confidence: 54%

Neurodevelopmental Outcome of Prematurely Born Children Treated With Recombinant Human Erythropoietin in Infancy

et al. 1999

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“…Embora, esse fator cause preocupação entre os profissionais que atuam junto a essa criança devido a possíveis seqüelas, como por exemplo, decorrentes do uso prolongado da oxigenoterapia que pode acarretar o aparecimento de retinopatias e entre outros problemas: déficit cognitivo, prejuízos neurológico e sensorial (Piecuch, Leonard, Cooper & Sehring, 1997), sendo encontradas quatro crianças no grupo MBP com déficit sensorial auditivo, nessa amostra. Além disso, o nível cognitivo das crianças na faixa etária estudada, em geral, não apresentou-se comprometido, tendo em vista o desempenho alcançado no Raven revelando que a maioria apresenta um nível intelectual médio.…”

Section: Discussionunclassified

História de desenvolvimento e comportamento de crianças nascidas pré-termo e baixo peso (< 1.500 g)

Carvalho

Linhares

Martinez

2001

Psicol. Reflex. Crit.

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ResumoO presente estudo comparou a história de desenvolvimento, aprendizagem e comportamento de 20 crianças de 8 a 10 anos nascidas pré-termo < 1500g (MBP) emparelhadas a 20 crianças controle nascidas a termo. Foram realizadas entrevistas e foi aplicada a Escala Comportamental de Rutter nas mães e o Raven nas crianças. Verificou-se sinais de atraso na aquisição de comportamentos psicomotores iniciais e lateralidade manual canhestra no MBP em relação ao controle. Na fase escolar, a maioria das crianças de ambos os grupos apresentou nível intelectual médio e estava freqüentando escola regular. As crianças MBP apresentaram mais repetência escolar do que as controles e reuniram uma parcela de 20% de crianças com déficit auditivo. Embora em ambos os grupos tivesse indicação de problemas comportamentais na Rutter, as crianças MBP apresentaram mais problemas respiratórios, enurese noturna, recusa escolar, agitação, impaciência, inquietude e agarramento à mãe em comparação a escolares de Ribeirão Preto. Palavras-chave: Pré-termo; muito baixo peso; desenvolvimento cognitivo; comportamento; aprendizagem. Developmental History and Behavior of Pre-Term and Low Birth-Weight Children (<1.500g) AbstractThe aim of this study is to compare the developmental history, learning and behavior of 20 pre-term and very low birth-weight children (VLB) and 20 full-term children at eight-ten years old. Data collection included interviews and the Child Behavioral Scale administered to the mothers and the Raven test to the children. Signs of delay in psychomotor behaviors acquisitions and predominance of the left hand use in the VLB compared to the control group were detected. In the school phase, most of the children of both groups presented average intellectual level and were attending regular schools. In the VLB group there was a significantly higher proportion of school failure than in the control group and there were 20% of children with hearing impairment. Authough both groups had signs of behavior problems, the VLB group showed more respiratory problems, enuresis, school-refuse, agitation, impatience and attachment to the mother than school children from Ribeirão Preto.

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“…Such an inverse relationship was previously demonstrated for the incidence of major disabilities in very preterm and/or VLBW children 67 and is related to the risk for disruption in cortical development (corticogenesis) and brain connectivity, which increases when BW and GA decrease. 68 For the extremely preterm or extremely low BW infants, adverse concomitant sequelae (such as abnormal cerebral ultrasound findings, chronic lung disease, and postnatal steroid administration), may explain abnormal neurodevelopmental outcomes in addition to BW and GA. 69,70 It has been questioned whether academic underachievement, behavioral problems, and neurocognitive dysfunction in very preterm and/or VLBW children improve or worsen over time. 6 Some studies have found evidence in support for the idea that the gap between very preterm and/or VLBW children and term-born peers becomes smaller with increasing age.…”

Section: Bw and Gamentioning

confidence: 99%

Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Low Birth Weight Children

et al. 2009

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Birth Weight Children Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Lowhttp://www.pediatrics.org/cgi/content/full/124/2/717 located on the World Wide Web at:The online version of this article, along with updated information and services, is Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Low Birth Weight Children abstract OBJECTIVE: Sequelae of academic underachievement, behavioral problems, and poor executive function (EF) have been extensively reported for very preterm (Յ33 weeks' gestation) and/or very low birth weight (VLBW) (Յ1500 g) children. Great variability in the published results, however, hinders the field in studying underlying dysfunctions and developing intervention strategies. We conducted a quantitative meta-analysis of studies published between 1998 and 2008 on academic achievement, behavioral functioning, and EF with the aim of providing aggregated measures of effect size for these outcome domains.METHODS: Suitable for inclusion were 14 studies on academic achievement, 9 studies on behavioral problems, and 12 studies on EF, which compared a total of 4125 very preterm and/or VLBW children with 3197 term-born controls. Combined effect sizes for the 3 outcome domains were calculated in terms of Cohen's d. Q-test statistics were performed to test homogeneity among the obtained effect sizes. Pearson's correlation coefficients were calculated to examine the impact of mean birth weight and mean gestational age, as well as the influence of mean age at assessment on the effect sizes for academic achievement, behavioral problems, and EF. RESULTS:Combined effect sizes show that very preterm and/or VLBW children score 0.60 SD lower on mathematics tests, 0.48 SD on reading tests, and 0.76 SD on spelling tests than term-born peers. Of all behavioral problems stacked, attention problems were most pronounced in very preterm and/or VLBW children, with teacher and parent ratings being 0.43 to 0.59 SD higher than for controls, respectively. Combined effect sizes for parent and teacher ratings of internalizing behavior problems were small (Ͻ0.28) and for externalizing behavior problems negligible (Ͻ0.09) and not significant. Combined effect sizes for EF revealed a decrement of 0.57 SD for verbal fluency, 0.36 SD for working memory, and 0.49 SD for cognitive flexibility in comparison to controls. Mean age at assessment was not correlated with the strength of the effect sizes. Mathematics and reading performance, parent ratings of internalizing problems, teacher ratings of externalizing behavior, and attention problems, showed strong and positive correlations with mean birth weight and mean gestational age (all r values Ͼ 0.51). CONCLUSIONS:Very preterm and/or VLBW children have moderate-toseveredeficitsinacademicachievement,attentionproblems,andinternalizing behavioral problems and poor EF, which are adverse outcomes that were strongly correlated to their immaturity at birth. During transition to young adulthood these children continue to lag behind term-born peers.

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Outcome of Extremely Low Birth Weight Infants (500 to 999 Grams) Over a 12-Year Period

Abstract: In this study of ELBW infants, low birth weight was not associated with abnormal outcome. The risk factors of ICH III-IV/cystic PVL, chronic lung disease, and high social risk were associated with abnormal outcome.

Cited by 156 publications

References 14 publications

Neurodevelopmental Outcome of Prematurely Born Children Treated With Recombinant Human Erythropoietin in Infancy

Neurodevelopmental Outcome of Prematurely Born Children Treated With Recombinant Human Erythropoietin in Infancy

História de desenvolvimento e comportamento de crianças nascidas pré-termo e baixo peso (< 1.500 g)

Meta-Analysis of Neurobehavioral Outcomes in Very Preterm and/or Very Low Birth Weight Children

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