Outcome of Fertility-Sparing Treatment With Progestins in Young Patients With Endometrial Cancer

Gotlieb, Walter H.; Beiner, Mario; Shalmon, Bruria; Korach, Yaacov; Segal, Yael; Zmira, Nissim; Koupolovic, Joure; Ben‐Baruch, Gilad

doi:10.1097/00006250-200310000-00013

Cited by 55 publications

(97 citation statements)

References 29 publications

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“…The first case reports regarding conservative treatment of endometrial cancer were published in the early 1960s. Since then, the safety and efficacy of hormonal therapy as a primary treatment of endometrial cancer in reproductive age have been reported in several articles (13,14). Lately, papers have been published about hysteroscopic resection of the endometrium in order to preserve fertility (15), and hysteroscopic endomyometrial resection as an alternative treatment to hysterectomy for an early stage endometrial cancer in both pre-and postmenopausal women (16).…”

Section: Discussionmentioning

confidence: 99%

Two cases of successful pregnancies after hysteroscopic removal of endometrioid adenocarcinoma grade I, stage IA, in young women with Lynch syndrome

Márton¹,

Vraneš²,

Šparac³

et al. 2014

J Turkish German Gynecol Assoc

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Section: Discussionmentioning

confidence: 99%

Two cases of successful pregnancies after hysteroscopic removal of endometrioid adenocarcinoma grade I, stage IA, in young women with Lynch syndrome

Márton¹,

Vraneš²,

Šparac³

et al. 2014

J Turkish German Gynecol Assoc

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“…However, progesterone therapy has been used for young women with either atypical endometrial hyperplasia or grade 1 endometrial hyperplasia who desire fertility preservation and women who are very poor surgical candidates. 14,66,67 …”

Section: Hormone Replacement Therapy For Endometrial Cancersmentioning

confidence: 99%

Uterine Neoplasms

Greer¹,

Wj²,

Abu‐Rustum³

et al. 2009

J Natl Compr Canc Netw

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“…Response to treatment has been high (rates of 73%-81%), but not absolute [28][29][30][31] . Recurrence rates are also appreciable (18%-40% with follow-up times up to 357 months) [28][29][30][32][33][34] . Although progestin management of early endometrial carcinoma has shown success (recent pregnancy rates of 40% and subsequent live birth rates up to 47% 30 ), this management route is evidently not without risk.…”

Section: Progestins and Endometrial Cancermentioning

confidence: 99%

Oncofertility in Canada: Gonadal Protection and Fertility-Sparing Strategies

Ronn

Holzer

2013

Current Oncology

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Background: Cancer can be a devastating diagnosis. In particular, malignancy and its indicated treatments have profoundly negative effects on the fertility of young cancer patients. Oncofertility has emerged as a new interdisciplinary field to address the issue of gonadotoxicity associated with cancer therapies and to facilitate fertility preservation. In Canada, fertility issues are often inadequately addressed despite the availability of resources. The goal of this four-part series is to facilitate systemic improvements in fertility preservation for adolescent and young adult Canadians with a new diagnosis of cancer. Methods: Here, we review the fertility preservation measures currently available. Medical and surgical strategies are both outlined. Results: Fertility-preserving strategies and gonadal protection have demonstrated variable success in a number of approaches. The value of hormone suppression is still in question for women. Progestins for endometrial cancer and alternative chemotherapies are other medical approaches. Gonadal shielding and protective surgical approaches have also been attempted. Conclusions: The techniques discussed here may be selectively considered and integrated into patient care in an attempt to preserve future fertility before initiating cancer treatment.

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Outcome of Fertility-Sparing Treatment With Progestins in Young Patients With Endometrial Cancer

Cited by 55 publications

References 29 publications

Two cases of successful pregnancies after hysteroscopic removal of endometrioid adenocarcinoma grade I, stage IA, in young women with Lynch syndrome

Two cases of successful pregnancies after hysteroscopic removal of endometrioid adenocarcinoma grade I, stage IA, in young women with Lynch syndrome

Uterine Neoplasms

Oncofertility in Canada: Gonadal Protection and Fertility-Sparing Strategies

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