Outcome of first line antiretroviral therapy (art) with respect to treatment Failure at ART CENTRE, B. J. Medical College, Civil Hospital, Ahmedabad

Amin, Bipin; Derasari, Urvi; Nihalani, Umesh; Purohit, Hemang; Shevkani, Manoj; Prajapati, Sanjeev; Prajapati, Girish; Mankad, Bankim; Shah, Asha; Kavina, Burzin

doi:10.1186/1742-4690-7-s1-p49

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“…In United States of America the treatment failure rates were 3.5% in 1990 and has raised to 12% in 2002 [8]. In B.J Medical College, Centre of excellence approved by NACO, Ahmedabad, India [11] where NACO guidelines followed the immunological failure was 2.3% and the virological failure among them was 1.70% of the 5847 patients. An Indian editorial [8] suggested at the end of 24 months the virological failure was quoted as 15% to 18% in India.…”

Section: Discussionmentioning

confidence: 99%

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Predicting Virological Failure with Immunological Criteria in First Line ART Patients in a Resource Poor Setting

Raja¹,

Chandrasekar²,

Krishnarajasekhar³

et al. 2014

WJA

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Indroduction: National Aids control Organisation in India implementing National AIDS control program uses WHO's immunological criteria to screen virological failure. Using immunological criteria to detect virological failure has to be assessed. Predicting virological failure with immunological criteria in resource limited settings had low sensitivity. Factors that influence the outcome are studied. Methods: Retrospective study in tertiary care centre for HIV and TB, Chennai, India. Out of 35,044 on ART between January 2008 and September 2009, 452 suspected immunological failures were referred. 273 screened for virological failure. Frequency, sensitivity/specificity, positive/negative predictive values, chi-square test, odds-ratio, independent sample t test for viral load greater than 10,000 and 1000 of each immunological criterion using Epi-Info and SPSS version 19. Results: 172 had virological failure (62.09%). Average age of failed was 37.33. Single criteria's sensitivity was 60 to 84 for detecting virolological failure. Two or more criteria had specificity 55 to 79. Combination of two or more criteria increased odds ratio for virological failure. Positive predictive value was above 63 for all criteria. PPV was above 80 to the criterion all three positive. Conclusions: ART naive patients with >95% adherence the sensitivity of immunological criteria to detect virological failure is three times than earlier studies. Combination of criteria is more significantly associated with virological failure. Odds ratio doubled for two or more combination of criteria. Immunological criteria is affordable/acceptable for screening virological failure, with adherence > 95% and longer the duration of ART.

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Section: Discussionmentioning

confidence: 99%

“…In this tertiary care centre for HIV and TB, Tambaram study at the end of September 2009 out of 37,386 patients [11] registered by ART centers in Tamilnadu, 452 (1.2%) from all over Tamilnadu were referred with suspected immunological failure. The reasons for the low rates of referral may be 1) Deaths of many patients without getting ART.…”

Section: Discussionmentioning

confidence: 99%

Predicting Virological Failure with Immunological Criteria in First Line ART Patients in a Resource Poor Setting

Raja¹,

Chandrasekar²,

Krishnarajasekhar³

et al. 2014

WJA

View full text Add to dashboard Cite

show abstract

Outcome of first line antiretroviral therapy (art) with respect to treatment Failure at ART CENTRE, B. J. Medical College, Civil Hospital, Ahmedabad

Abstract: All the ever started 1 st Line ART patients were evaluated for treatment failure as per Indian National ART Guidelines at our institute.

Cited by 1 publication

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Predicting Virological Failure with Immunological Criteria in First Line ART Patients in a Resource Poor Setting

Predicting Virological Failure with Immunological Criteria in First Line ART Patients in a Resource Poor Setting

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