Outcome of hematopoietic cell transplantation in children with sickle cell disease, a single center's experience

Hematopoietic SCT for the Black African and non-Black African variants of sickle cell anemia

“…9,14 The second severe hemoglobinopathy to be radically cured with the same transplantation protocol was SCA. [15][16][17][18] Migration from areas with high prevalence to areas with low or no prevalence in European countries has been growing during the last 20 years as a result of populations moving in an attempt to escape extreme poverty, and SCA has become the predominant genetic Hb disorder in the occidental part of the world. The Arab-Indian genetic haplotype and the Benin African haplotype are almost equally distributed today in Western countries.…”

“…[15][16][17][18][19][20][21][22][23] The results of several major studies summarized in Table 5 show an OS of 490% and an EFS of 480%.…”

Successful hematopoietic cell transplantation in a child with sickle cell disease and systemic lupus erythematosus

“…Walters et al 6 first noted seven out of 21 recipients developed either seizures and/or intracranial hemorrhage post transplant. In a more recent report, Majumdar et al 1 reported four out of 10 children with sickle cell disease who experienced similar complications after HSCT. Those who have a history of stroke appear to be at higher risk.…”

“…1,2 Most of the reported experience in SLE involves the use of autologous stem cells, though allogeneic HSCT has been used in more refractory cases. 4 Children with sickle cell disease may be at risk of developing SLE 5 , which, as illustrated in this case, makes life more difficult.…”

“…1 HSCT may be an acceptable treatment for patients with severe systemic lupus erythematosus (SLE). 2 We report our experience of matched sibling HSCT in an 11-year-old girl with sickle cell disease complicated by SLE.…”