Outcome of Hepatitis B and C Virus Infection on Graft Function After Renal Transplantation

Behzad-Behbahani, Abbas; Mojiri, Anahita; Tabei, S. Z.; Farhadi, Ali; Pouransari, R.; Yaghobi, Ramin; Rahsaz, Marjan; Banihashemi, Mehrzad; Malekhosseini, Seyed Ali; Javid, Amir; Bahador, Abbas; Reisjalali, A.; Behzadi, S; Salehipour, Mehdi; Salahl, A.; Davari, R Darakhshan; Janghorban, Parisa; Torb, A.; Salah, Ayman

doi:10.1016/j.transproceed.2005.07.039

Cited by 21 publications

(16 citation statements)

References 5 publications

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“…HBV infection have been reported to account for a significant portion of patient mortality in RTRs because of complications such as chronic liver disease, liver cirrhosis, hepatoma and hepatic failure [2][3][4][5][6][7][8][9]. Fornairon et al [7] performed serial liver biopsies in 151 RTRs with positive HBsAg and showed that cirrhosis developed in Besides the host factors, virological factors have been associated with a higher risk of LC or HCC in chronic HBV patients.…”

Section: Discussionmentioning

confidence: 99%

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The role of HBV genotype core promoter and precore mutations in advanced liver disease in renal transplant recipients

Tsai

Chen

Lee

et al. 2009

Journal of Hepatology

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Section: Discussionmentioning

confidence: 99%

“…Many studies have reported HBV disease progression after renal transplantation [2,4,[6][7][8][9]. Previous studies have demonstrated a significantly higher 10-year survival rate in non-infected RTRs than in HBsAg-positive patients [3].…”

Section: Introductionmentioning

confidence: 99%

The role of HBV genotype core promoter and precore mutations in advanced liver disease in renal transplant recipients

Tsai

Chen

Lee

et al. 2009

Journal of Hepatology

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“…In Asian‐Pacific countries, the carrier rate for HBV varies from 1–10%, and from 1–25% in kidney transplant recipients (35). There is a low incidence of HBV and HCV infection in the Iranian population (36). In the current study, only 1.4% of patients developed HBV infection, which was in line with the reports from Iran and other countries (18, 33, 36).…”

Section: Discussionmentioning

confidence: 99%

Infectious complications after kidney transplantation: a single‐center experience

Pourmand

Salem

Mehrsai

et al. 2007

Transplant Infectious Dis

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Infectious complications after renal transplantation are associated with significant morbidity and mortality. The prevalence of infections in transplant recipients varies from country to country. This study sought to assess the overall incidence of post-transplant infectious complications at our research center in Iran, compared with other centers in the world. Between 2002 and 2004, 179 renal transplantations were performed in our center. Of these, 142 were studied and followed for 1 year. Immunosuppressive regimens were cyclosporine, mycophenolate mofetil, and prednisolone. The overall incidence of infections was 54.2%. The most common sites of infections were the urinary tract (41.5%) and the respiratory tract (6.3%). The most frequent causes of infections were Klebsiella (24%) and cytomegalovirus (CMV) (17.6%). Wound infection occurred in 4.9% of the patients. Three (2.1%) patients developed hepatitis C and 2 (1.4%) had mycobacterial infections. There was no case of Pneumocystis pneumonia. Overall mortality was 7.7%. Infection-related mortality was 3.5%. In conclusion, this study identifies infections as the cause of morbidity and mortality in the post-transplant period. There was a low incidence of tuberculosis (<2% yearly) and a high incidence of CMV disease in our recipients.

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“…However, HCV-infected renal allograft recipients with abnormal liver function had inferior survival rates. Several other studies [131,132,133,134,135], with the exception of one [136], with shorter than 10-year follow-up periods reported no adverse impact of HCV infection on graft and/or patient survival. The promising results of the aforementioned studies suggest that for many patients, the benefits of renal transplantation outweigh its potential risks imposed by immunosuppression.…”

Section: Natural History and Liver Histopathology In Hcv-infected Hd mentioning

confidence: 98%

Hepatitis C in Hemodialysis Patients: Current Global Magnitude, Natural History, Diagnostic Difficulties, and Preventive Measures

2008

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Hepatitis C virus (HCV) infection is a significant cause of morbidity and mortality in hemodialysis (HD) patients. The reported prevalence of HCV among the HD population has varied greatly from 1.9 to 84.6% in different countries in recent years. The length of time on HD is generally believed to be associated with HCV acquisition in HD subjects. Nevertheless, several recent reports failed to recognize any significant role of blood transfusion. Although there are some considerations about the accuracy of serologic testing in detecting HCV in HD patients, the accumulated data in this review suggest the false-negativity rate to be not more than 1.66% (153/9,220). Therefore, substituting virologic for serologic testing in the routine diagnosis of HCV infection in HD patients seems unreasonable. Several phylogenetic analyzes of viral isolates suggested nosocomial patient-to-patient transmission of HCV among HD patients for which the main potential source is believed to be contaminated hands and articles. However, isolation of HCV-infected HD patients and use of dedicated machines are currently unjustified while strict adherence to universal precautions seems to be enough to control disease spread in HD units. The present article is an update on epidemiological and clinical features of HCV in HD population.

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Outcome of Hepatitis B and C Virus Infection on Graft Function After Renal Transplantation

Cited by 21 publications

References 5 publications

The role of HBV genotype core promoter and precore mutations in advanced liver disease in renal transplant recipients

The role of HBV genotype core promoter and precore mutations in advanced liver disease in renal transplant recipients

Infectious complications after kidney transplantation: a single‐center experience

Hepatitis C in Hemodialysis Patients: Current Global Magnitude, Natural History, Diagnostic Difficulties, and Preventive Measures

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