Outcome of High-Risk Stage IC, Grade 3, Compared With Stage I Endometrial Carcinoma Patients: The Postoperative Radiation Therapy in Endometrial Carcinoma Trial

Creutzberg, Carien L.; Putten, Wim L.J. van; Wárlám-Rodenhuis, Carla C.; Bergh, Alfons C.M. van den; Winter, K. De; Koper, P.; Lybeert, Marnix L.M.; Slot, Annerie; Lutgens, Ludy; Kroese, Marika C. Stenfert; Beerman, Herman; Lent, M. van

doi:10.1200/jco.2004.08.159

Cited by 266 publications

(129 citation statements)

References 30 publications

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“…The Post Operative Radiation Therapy in Endometrial Carcinoma (PORTEC) trial reported 5-year survival rates for patients with stage IB G2, IB G3, IC G1, IC G2, and IC G3 disease of 86%, 74%, 83%, 85%, and 58%, respectively. 3 Therefore, it is important to keep in mind that prognoses can differ dramatically across subgroups within stage I.…”

Section: Discussionmentioning

confidence: 99%

Does the revised International Federation of Gynecology and Obstetrics staging system for endometrial cancer lead to increased discrimination in patient outcomes?

Cooke

Pappas

Gaffney

2011

Cancer

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Section: Discussionmentioning

confidence: 99%

Does the revised International Federation of Gynecology and Obstetrics staging system for endometrial cancer lead to increased discrimination in patient outcomes?

Cooke

Pappas

Gaffney

2011

Cancer

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“…Although this neoplasm is generally considered non-aggressive, it is a heterogeneous disease with 5-year survival rates ranging from over 80 -90% for women with clinical stage I disease (Creutzberg et al, 2004). Currently, various clinicopathologic parameters are used to predict the outcome of the disease and to decide the need for adjuvant treatment: surgical stage, histological type, grade, depth of myometrial invasion, cervical stromal invasion, lymph node metastasis, lymph vascular involvement, and peritoneal cytology (Morrow et al, 1991;Grigsby et al, 1992); however, the majority of parameters have been criticised for their subjectivity and poor reproducibility (Nordstrom et al, 1996).…”

mentioning

confidence: 99%

Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis

et al. 2007

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N-acetylglucosaminyltransferase V (GnT-V) is an enzyme that catalyses b1 -6 branching of N-acetylglucosamine on asparagine-linked oligosaccharides of cell proteins. The present study aimed to investigate GnT-V expression and its prognostic significance in endometrial cancer. N-acetylglucosaminyltransferase V expression was studied by immunohistochemistry in 74 surgically resected endometrial cancers, and the staining intensity was evaluated. High GnT-V expression in tumour cells was found in 43 (58.1%) of the 74 cases, and was positively correlated with advanced patient age, histological grade, and lymph vascular space involvement. Patients with high GnT-V expression had significantly impaired overall survival and progression-free survival (PFS) (P ¼ 0.0041 and P ¼ 0.0023, respectively) compared to patients with low expression of GnT-V. On multivariate analysis, GnT-V expression was an independent prognostic factor for PFS (P ¼ 0.0364). b1 -6 branching of asparagine-linked oligosaccharides was also detected in GnT-V-positive endometrial cancer cells by leukoagglutinating phytohaemagglutinin (L 4 -PHA) staining, and the molecular size of the major glycoproteins recognised by L 4 -PHA was approximately 60 -200 kDa by lectin blot analysis. These results suggested that high GnT-V expression was correlated with an unfavourable clinical outcome, and that GnT-V is involved in the malignant potential of endometrial cancer by increasing the synthesis of b1 -6 branching of asparagine-linked oligosaccharides.

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“…15 The overall survival at 5 years was 58% for the IC grade 3 patients, compared to 74% for those with IB grade 3, and 83-86% for IB grade 2 and IC grade 1 and 2 disease (p<0.001).…”

Section: Pagementioning

confidence: 91%

A Case Report of Solitary Adrenal Metastasis from Early Stage Endometrial Carcinoma

Ladwa¹,

Crandon²,

Coward³

2014

Gynecol Obstet Res Open J

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Case Report ABSTRACTAlthough Type I endometrial cancers are generally associated with a good prognosis, specific histopathological features portend worse outcomes. Compared to type II tumours which have increased metastatic potential, this phenomenon is seldom seen in type I counterparts at presentation. Moreover, adrenal metastatic sites are rarer still with only one case report describing this pattern of dissemination to date. To our knowledge this is the first case report of an isolated adrenal metastasis from early stage type I endometrial cancer and highlights the heterogeneity which exists in this disease.

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Outcome of High-Risk Stage IC, Grade 3, Compared With Stage I Endometrial Carcinoma Patients: The Postoperative Radiation Therapy in Endometrial Carcinoma Trial

Abstract: Patients with stage IC, grade 3 endometrial carcinoma are at high risk of early distant spread and endometrial carcinoma-related death. Novel strategies for adjuvant therapy should be explored to improve survival for this patient group.

Cited by 266 publications

References 30 publications

Does the revised International Federation of Gynecology and Obstetrics staging system for endometrial cancer lead to increased discrimination in patient outcomes?

Does the revised International Federation of Gynecology and Obstetrics staging system for endometrial cancer lead to increased discrimination in patient outcomes?

Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis

A Case Report of Solitary Adrenal Metastasis from Early Stage Endometrial Carcinoma

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