Outcome of ICSI with ejaculated spermatozoa in a series of men with distinct ultrastructural flagellar abnormalities

Abstract

The rate of ICSI success may be influenced by the type of flagellar abnormality. ICSI provides a suitable solution for patients with sperm flagellar defects but raises the question of the consequences of a specific (and primary flagellar) abnormality on oocyte fertilization, on embryo and fetal development as well as on live birth.

Successful twin birth following blastocyst culture of embryos derived from the immotile ejaculated spermatozoa from a patient with primary ciliary dyskinesia: A case report

“…Additional aberrations have included absence of the radial spokes [32], peripheral microtubule defects, dysplasia for the fibrous sheath [12], non-specific axoneme defects [33], complete ciliary aplasia, orientation defects [34], and absence of the central microtubule pair [28,31,35]. Wolff et al also reported a case of immotile cilia syndrome where the axonemes of the spermatozoa tails were complete except they lacked the two central microtubules.…”

Male factor infertility and ART

“…Injection of uncharacterized immotile sperm makes fertilization after ICSI unpredictable and decreases both fertilization and pregnancy rates. 50,51 When no motile spermatozoa are found in the ejaculate, the patient should produce a second ejaculate. In most patients, the second semen sample often contains a few motile spermatozoa for use with ICSI.…”

Meiotic segregation and sperm DNA fragmentation in Tunisian men with dysplasia of the fibrous sheath (DFS) associated with head abnormalities

“…In the literature, few individual case reports have been published, there were 15 reported cases of DFS/stump tails/short tails [4,13,15]. Bacceti et al, [14] reported a large series of 12 patients with DFS sperm defects while Mitchell et al, [43] investigated ICSI outcomes for 21 patients with distinct ultrastructural flagellar abnormalities, 12 of them presented with "short tail" syndrome. Rawe et al, [19] and Moretti et al, [20] have reported respectively one and two cases of DFS sperm defect associated with acephalic sperm and abnormal head-tail attachment.…”

“…The mean overall fertilization rate was 63 %, 10 pregnancies were achieved (83 %), two miscarriages (20 %) and eight deliveries (67 %), and a total of 14 healthy babies born. Mitchell et al, [43] reported ICSI outcomes for 21 patients with distinct ultrastructural flagellar abnormalities, 12 of them presented with "short tail" syndrome . Only for 14 out of 21 patients fertilization was achieved with a mean rate of 62 %, pregnancy rate of 57 % (12 pregnancies), and live-birth rate of 43 % (9 deliveries).…”