Outcome of in vitro fertilization in patients with proven poor ovarian responsiveness after early vs. mid-follicular LH exposure: a prospective, randomized, controlled study

Revelli, Alberto; Chiadò, Alessandra; Guidetti, Daniela; Bongioanni, Francesca; Rovei, Valentina; Gennarelli, Gianluca

doi:10.1007/s10815-012-9804-0

Cited by 15 publications

(10 citation statements)

References 27 publications

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“…An interesting finding was reported by Revelli et al ( 9 ). A total number of 848 IVF patients with the same base line characteristics were recruited in a real life population study.…”

Section: Discussionsupporting

confidence: 64%

“…LH activity can be administered in different forms, either adding r-LH to recombinant follicle stimulating hormone (rFSH) or using highly puriﬁed human menopausal gonadotropine (hMG) which provides follicle stimulating hormone and exogenous LH activity ( 1 , 2 , 4 , 5 ). Although Hill and Alvigi showed superiority of adding exogenous LH to rFSH over FSH alone in terms of increased number of mature oocytes, good quality zygotes and higher implantation rates but other investigators reported no improvement in the outcomes when exogenous LH is added ( 6 - 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Controlled ovarian stimulation with r-FSH plus r-LH vs. HMG plus r-FSH in patients candidate for IVF/ICSI cycles: An RCT

Tehraninejad¹,

Taghinejad²,

Rashidi³

et al. 2017

IJRM

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Background:Different combination of gonadotropin preparation has been introduced with no definite superiority of one over others in in vitro fertilization (IVF), but individualized regimens for each patient are needed.Objective:The aim of the present study was to investigate the effect of controlled ovarian stimulation with recombinant- follicle stimulating hormone (r-FSH) plus recombinant-luteinizing hormone (rLH) versus human menopausal gonadotropin (HMG) plus r-FSH on fertility outcomes in IVF patients.Materials and Methods:This is a randomized clinical trial study that was performed from October 2014-April 2016 on 140 infertile patients with a set of inclusion criteria that referred to infertility clinics in Vali- asr and Gandhi Hospital in Tehran. The women were randomly divided into two treatment groups. The first group (n=70) received rFSH from the second day of cycle and was added HMG in 6th day and the 2nd group (n=70), received rFSH from the second day of cycle and was added recombinant-LH in 6th day. Then ovum Pick-Up and embryo transfer were performed. In this study, we assessed the outcomes such as; chemical and clinical pregnancy rate, live birth and abortion rate.Results:Number of follicles in ovaries, total number of oocytes or M2 oocytes and quality of fetuses has no significant differences between two groups (p>0.05). Total number of fetuses were significantly higher in patients who received rFSH + HMG (p=0.02). Fertility outcomes consisted of: live birth rate, chemical pregnancy and clinical pregnancy rate were higher in rFSH + HMG group in comparison to rFSH +r-LH group (p<0.05).Conclusion:It seems that in IVF patients, HMG + rFSH used for controlled ovarian hyperstimulation have better effects on fertility outcomes, but in order to verify the results, it is recommended to implement studies on more patients.

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“…An interesting finding was reported by Revelli et al ( 9 ). A total number of 848 IVF patients with the same base line characteristics were recruited in a real life population study.…”

Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Controlled ovarian stimulation with r-FSH plus r-LH vs. HMG plus r-FSH in patients candidate for IVF/ICSI cycles: An RCT

Tehraninejad¹,

Taghinejad²,

Rashidi³

et al. 2017

IJRM

View full text Add to dashboard Cite

show abstract

“…However, other cleavage rate comparison between groups were statistically similar. studies which reporting a higher embryo ploidy rate and a lightly higher pregnancy rate [12], although in our study we only found the correlation with chemical pregnancy.…”

Section: Discussioncontrasting

confidence: 87%

Characteristic of Poor Responder Patients and the success rate of biochemical pregnancy in the administration of adjuvant recombinant Luteinizing Hormones in Yasmin Clinic, Jakarta

Marischa¹,

Pratama²,

Maidarti³

et al. 2017

Kme

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Introduction: Management for poor response patients is still a challenge for clinician engaged in Assisted Reproductive Technology. Various protocols have been proposed to improve the outcome for patients, though no RCT can provide the evidence based of success rate of one protocol among others. Objective: Our purpose is to find the basic data of poor responder patients in Yasmin Clinic, Jakarta and to assess the IVF cycle outcome after the addition of recombinant Luteinizing Hormones. Material and methods: This is a cohort retrospective study taken from medical records of IVF patients at Yasmin Clinic, Cipto Mangunkusumo Hospital between January 2012 to January 2015. Result: Two hundreds and eighty-one poor response patients were selected for ART during January 2012 to January 2015, were divided into four main group. Control group received gonadotrophin protocol, while group II received additional recombinant Luteinizing hormones (rLH), Group III received additional Growth hormones (GH) and Group IV received additional rLH and GH both. Discussion: Our study demonstrated the follicle count, the oocyte count and the cleavage rate were statistically significant difference between control group and LH group. Where the oocyte count and follicle count were significantly higher, but the cleavage rate with LH showed negative correlation compare with control group. Conclusion: In this study we found that with adjuvant therapy with recombinant Luteinizing Hormones, produced higher follicles count and oocyte count.

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“…The favorable effect of LH addition in combination with FSH for follicular stimulation during IVF in poor responders or older women has been supported by some studies. [17–19] Alberto Revelli's group [4] also reported that the addition of LH at early and mid-follicular stage have comparable effects on the IVF outcome in poor responders. However, in normogonadotropic women, the effect of LH addition remains unsettled.…”

Section: Discussionmentioning

confidence: 99%

“…[1–3] LH induces theca cells of developing follicles to produce androgens and polypeptide growth factors which enhance follicular response to FSH during follicular recruitment and selection. [4,5] Besides, LH could also stimulate the growth of large antral follicles. [6,7]…”

Section: Introductionmentioning

confidence: 99%

A cohort study of both human menopausal gonadotropin (HMG) and recombinant luteinizing hormone addition at early follicular stage in in vitro fertilization outcome

et al. 2019

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At present, the precise role of human menopausal gonadotropin (HMG) and recombinant luteinizing hormone (rLH) supplementation at an early time of follicular phase on in vitro fertilization (IVF)/intra cytoplasmatic sperm injection (ICSI) outcomes remains uncertain. Here infertile women of normal ovarian function undergoing their first cycle of IVF/ICSI were studied and were randomly allocated into 3 groups. Group 1, ovarian stimulation with 150IU recombinant follicle-stimulating hormone (FSH) alone. Group 2, patients received 75IU rFSH and 75IU HMG. Group 3 patients were given 150IU rFSH and 75IU rLH. There were no significant differences in the clinical characteristics, ovarian response, the biochemical, clinical and ongoing pregnancy rates among the 3 groups. No significant differences were found in biochemical, clinical and ongoing pregnancy rates between the patients whose LH levels were lower than 0.75 mIU/ml and those above this threshold in group 1. Furthermore, there were also no significant differences in biochemical, clinical and ongoing pregnancy rates among the 3 group patients whose LH level lower than 0.75 mIU/ml. The results showed that either the addition of HMG or rLH supplementation at an early time of follicular phase produce no significant benefit on IVF outcome in patients with normal ovarian function.

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Outcome of in vitro fertilization in patients with proven poor ovarian responsiveness after early vs. mid-follicular LH exposure: a prospective, randomized, controlled study

Abstract: Adding LH to FSH from day 1 or from day 7 of ovarian stimulation in a GnRH-agonist long protocol exerts comparable effects on IVF outcome in poor responders.

Cited by 15 publications

References 27 publications

Controlled ovarian stimulation with r-FSH plus r-LH vs. HMG plus r-FSH in patients candidate for IVF/ICSI cycles: An RCT

Controlled ovarian stimulation with r-FSH plus r-LH vs. HMG plus r-FSH in patients candidate for IVF/ICSI cycles: An RCT

Characteristic of Poor Responder Patients and the success rate of biochemical pregnancy in the administration of adjuvant recombinant Luteinizing Hormones in Yasmin Clinic, Jakarta

A cohort study of both human menopausal gonadotropin (HMG) and recombinant luteinizing hormone addition at early follicular stage in in vitro fertilization outcome

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