Outcome of intracytoplasmic sperm injection in patients with polycystic ovary syndrome or isolated polycystic ovaries

Esinler, İbrahim; Bayar, Ülkü; Bozdağ, Gürkan; Yaralı́, Hakan

doi:10.1016/j.fertnstert.2005.04.028

Cited by 49 publications

(41 citation statements)

References 25 publications

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“…Moreover, the actual incidence rate of moderate to severe OHSS was significantly higher in the PCOS group (11.5 %) compared to the controls (4.9 %). Such findings are all in line with those reported by others [11,12,14,15]. There was also a trend of higher rate of moderate to severe OHSS in the isolated PCO group (8.2 %) which corresponded to a 67 % risk increment compared to the controls although not reaching statistical significance.…”

Section: Discussionsupporting

confidence: 92%

“…This echoed the findings in some reported studies [10,[12][13][14][15], while some others have reported higher pregnancy rates in women with PCO compared to controls [9,11]. In contrast to some of the reported studies, our study made use of age-matched controls, which eliminated the confounding effect of age to the treatment outcome.…”

Section: Discussionsupporting

confidence: 72%

“…There were a few studies on the IVF outcome of this group [9][10][11][12][13][14][15]. Some of these reported similar pregnancy or live birth rates in the isolated PCO group compared to controls [10,[12][13][14][15], whereas some reported higher pregnancy rates than controls [9,11].…”

Section: Introductionmentioning

confidence: 99%

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Cumulative live-birth rate in women with polycystic ovary syndrome or isolated polycystic ovaries undergoing in-vitro fertilisation treatment

Lee

Lau

et al. 2013

J Assist Reprod Genet

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Purpose This retrospective cohort study evaluated the cumulative live birth rate in women with polycystic ovary syndrome (PCOS) and isolated polycystic ovaries (PCO) undergoing in-vitro fertilisation (IVF) treatment. Methods We studied 104 women with PCOS, 184 with PCO and 576 age-matched controls undergoing the first IVF treatment cycle between 2002 and 2009. The main outcome measure was cumulative live birth in the fresh plus all the frozen embryo transfers combined after the same stimulation cycle. Results Women in both the PCOS (n =104) and isolated PCO groups (n =184) had higher ovarian response parameters compared to age-matched controls (n =576), and higher rates of withholding fresh embryo transfer for risk of ovarian hyperstimulation syndrome (OHSS). The actual incidence of moderate to severe OHSS was significantly higher in the PCOS (11.5 %) but not the isolated PCO group (8.2 %) compared to controls (4.9 %). The live birth rates in the fresh cycle were comparable among the 3 groups, but the PCOS group had a significantly higher miscarriage rate compared to the other 2 groups. Cumulative live birth rate was significantly higher in the isolated PCO group (60.3 %), but not the PCOS group (50.0 %), compared to controls (47.5 %).Conclusions Women in the isolated PCO group, but not the PCOS group, had a significantly higher cumulative live birth rate compared to controls. This could be explained by the quantitative effect of the higher number of transferable embryos obtained per stimulation cycle, which is uncompromised by the unfavourable embryo competence otherwise observed in PCOS.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 72%

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Cumulative live-birth rate in women with polycystic ovary syndrome or isolated polycystic ovaries undergoing in-vitro fertilisation treatment

Lee

Lau

et al. 2013

J Assist Reprod Genet

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“…With more retrieved oocytes and cleaved embryos available to select for embryo transfer, PCOS patients undergoing IVF often achieve a clinical pregnancy rate comparable to that of similarly treated normal women [94][95][96]. Nevertheless, such PCOS patients also have increase risks of implantation failure and pregnancy loss [97] as well as impaired oocyte fertilization unrelated to gross chromosomal abnormalities or nuclear maturation [95,96,[98][99][100].…”

Section: Oocyte Developmental Competencementioning

confidence: 99%

Polycystic ovary syndrome and its developmental origins

Dumesic

Abbott

Padmanabhan

2007

Rev Endocr Metab Disord

256

168

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The prenatal testosterone (T)-treated adult female rhesus monkey is one animal model of polycystic ovary syndrome (PCOS) in women, with early prenatal T excess programming a permanent PCOS-like phenotype characterized by luteinizing hormone (LH) hypersecretion from reduced hypothalamic sensitivity to steroid negative feedback and relative insulin excess from increased abdominal adiposity. These combined reproductive and metabolic abnormalities are associated with ovarian hyperandrogenism and follicular arrest in adulthood, as well as premature follicle differentiation and impaired embryo development during gonadotropin therapy for in vitro fertilization (IVF). A second animal model for PCOS, the prenatal T-treated sheep also is characterized by LH hypersecretion from reduced hypothalamic sensitivity to steroid negative feedback, persistent follicles and insulin resistance, but also is associated with intrauterine growth retardation and compensatory growth after birth. The ability of prenatal T excess in both species to alter the developmental trajectory of multiple organ systems in utero provides evidence that the hormonal environment of intrauterine life programs target tissue differentiation, raising the possibility that T excess in human fetal development promotes PCOS in adulthood. Such a hypothesis must include data from clinical studies of PCOS women to clarify the homology between these PCOS-like animal models and PCOS per se in reproductive and metabolic function. Future studies should develop new clinical strategies that improve pregnancy outcome and minimize pregnancy loss in women with disorders of insulin action, including PCOS, obesity and diabetes mellitus as well as minimize transgenerational susceptibility to adult PCOS and its metabolic derangements in male close relatives.

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“…Studies regarding the impact of PCOS or PCOM on oocyte competence are conflicting [28][29][30][31][32][33]. Many factors could have been responsible on this contradiction such as ovulation induction program, patient age and ethnicity [34], and BMI.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes in Infertile Women with Polycystic Ovaries following Intracellular Sperm Injection

2017

IJSR

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Polycystic ovary syndrome (PCOS) is a complex endocrine condition characterized by polycystic ovarian morphology (PCOM), oligo-or anovulation, and clinical or biochemical hyperandrogenism. Intracytoplamic sperm injection (ICSI) has been used extensively in treatment of infertile women with PCOS. In Iraq, pregnancy outcomes in PCOS patients following ICSI have yet to be evaluated. This study has therefore been conducted to define pregnancy outcomes in Iraqi PCOS patients as well as to define oocyte meiotic competence and normality following ovarian hyperstimulation. Although high doses of gonadotropin were used in infertile women with normal ovaries, the numbers of retrieved oocytes and estradiol peak levels were higher in patients with PCOM and PCOS than in patients with normal ovaries(P≤0.01). Wealso found that PCOM women have higher antral follicle count (AFC) than did PCOS women(P=0.0001). Moreover, significant high mean numbers of immature, mature, and degenerated oocytes were observed in PCOS and PCOM patients in comparison to those in control patient, which might be due to the high bulk of AFC and consequently higher numbers of oocyte recovered in PCOS or PCOM. As for ICSI outcomes, PCOS or PCOM patients had significantly higher fertilization, grade one embryo, embryo transfer and implantation, pregnancy, and live birth rates than did control patients. It is concluded that infertile women with PCOS or PCOM have higher pregnancy rates than do infertile women with unexplained or tubal-type infertility following ICSI.

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Outcome of intracytoplasmic sperm injection in patients with polycystic ovary syndrome or isolated polycystic ovaries

Cited by 49 publications

References 25 publications

Cumulative live-birth rate in women with polycystic ovary syndrome or isolated polycystic ovaries undergoing in-vitro fertilisation treatment

Cumulative live-birth rate in women with polycystic ovary syndrome or isolated polycystic ovaries undergoing in-vitro fertilisation treatment

Polycystic ovary syndrome and its developmental origins

Pregnancy Outcomes in Infertile Women with Polycystic Ovaries following Intracellular Sperm Injection

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