Outcome of laparoscopic ovariohysterectomy or ovariectomy in dogs with von Willebrand disease or factor VII deficiency: 20 cases (2012–2014)

Abstract

OBJECTIVE To describe surgical techniques and perioperative management of dogs with von Willebrand disease (VWD) or factor VII (FVII) deficiency undergoing laparoscopic ovariohysterectomy or ovariectomy and evaluate outcomes. DESIGN Retrospective case series. ANIMALS 20 client-owned dogs with VWD (n = 16) or FVII deficiency (4). PROCEDURES Dogs with VWD or FVII deficiency that underwent laparoscopic ovariohysterectomy or ovariectomy between 2012 and 2014 were retrospectively identified via a multi-institutional review of medical records. RESULTS Median expression of von Willebrand factor was 19% (interquartile range, 18% to 30%). All 16 dogs with VWD were Doberman Pinschers, and all were pretreated with desmopressin; 4 also received cryoprecipitate. One of 4 dogs with FVII deficiency received plasma preoperatively, and 1 was treated with desmopressin; 2 dogs received no preoperative treatment. Laparoscopic ovariectomy was performed in 9 dogs with VWD and 2 dogs with FVII deficiency, laparoscopic ovariectomy with gastropexy was performed in 6 dogs with VWD and 1 dog with FVII deficiency, and laparoscopic-assisted ovariohysterectomy was performed in 1 dog with VWD and 1 dog with FVII deficiency. Iatrogenic splenic laceration requiring conversion to laparotomy occurred during trocar insertion in 1 dog with VWD. No postoperative complications, including signs of hemorrhage, were reported for any dogs. CONCLUSIONS AND CLINICAL RELEVANCE Laparoscopic ovariohysterectomy or ovariectomy in dogs with VWD or FVII deficiency pretreated with desmopressin, cryoprecipitate, or plasma transfusions were not associated with clinical signs of hemorrhage, suggesting that minimally invasive ovariohysterectomy or ovariectomy may be considered in female dogs affected with these coagulopathies.

A systematic review of complications related to laparoscopic and laparoscopic‐assisted procedures in dogs

“…Classification of studies by organ system is presented in Tables S1 and S2. Numbers of studies and participants were reported within each organ/system group including female genital tract (22 studies [n = 1407 dogs]), 1,7,11,20,30‐47 urinary tract (7 studies [n = 114]), 3,48‐53 stomach (9 studies [n = 250]), 10,18,54‐59 intestinal tract (5 studies [n = 48]), 60‐64 liver (5 studies [n = 288]), 12,17,65‐67 adrenal gland (5 studies [n = 62]), 13,28,68‐70 spleen (7 studies [n = 111]), 19,71‐76 and other (4 studies that included gastropexy and ovariectomy procedures [n = 148]) 9,77‐79 . One experimental study, in which colopexy in seven male dogs was described, was classified as intestinal tract even though these dogs were also sterilized during the surgical procedure because this study reported only complications and outcomes related to colopexy 63 .…”

DNA profiling and personalised medicine from Nationwide Laboratories

“…Improving healthcare for the future An example of a genetic condition, where knowing about the condition early in the animal's life could allow for better healthcare provision, is von Willebrand disease. This is the most common inherited coagulopathy in dogs -estimated to affect 1.5% of the population (Keeshen et al, 2017). It is particularly associated with the Doberman Pinscher, although it has been identified in 54 breeds (Crespi et al, 2018).…”