Outcome of Living Donor Renal Transplantation in Obese Recipients

Schwarznau, Alice; Matevossian, E.; Novotny, Alexander; Stangl, Manfred

doi:10.1016/j.transproceed.2008.03.047

Cited by 16 publications

(10 citation statements)

References 2 publications

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“…It has been well documented that obesity is a risk factor for inferior transplant outcomes compared to a non-obese population (5). Multiple other reports have documented this decrease in graft survival in patients with obesity and in particular morbid obesity (5)(6)(7)(8)(9)(10). This may be because of increased tendency for rejection or other factors Fig.…”

Section: Discussionmentioning

confidence: 98%

Kidney transplantation in the morbidly obese: complicated but still better than dialysis

Bennett

McEvoy

Henell

et al. 2010

Clinical Transplantation

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Obese patients are denied renal transplantation in many centers. We report results regarding obesity from a new transplant program (1999 through 2007). Six hundred and forty-two patients were transplanted: 439 patients with BMI < 30 (Group 1), 109 patients with BMI 30.1-34.9 (Group 2), and 89 patients with BMI > 35 (Group 3). Follow-up was at least one yr. Medical and surgical management was performed by the same team throughout the study period. There were no demographic differences between groups except for increased diabetes in Groups 2 and 3. Actuarial graft and patient survivals were not statistically different between groups. Group 3 patients had numerical trends toward more delayed graft function and lower graft survivals but these did not reach statistical significance. Biopsy-proven rejections did not differ between groups. Wound infections were statistically significant in Groups 2 and 3 compared to Group 1 (p < 0.01). Despite increased wound infection rates with increased BMI, transplanting patients with morbid obesity results in better survival for individual patients than dialysis. Thus, there is no a priori ethical reason for treating obese ESRD patients differently from those with other comorbidities.

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Section: Discussionmentioning

confidence: 98%

Kidney transplantation in the morbidly obese: complicated but still better than dialysis

Bennett

McEvoy

Henell

et al. 2010

Clinical Transplantation

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“…Obese and morbidly obese subjects are less likely to undergo living donor renal transplantation when compared to underweight and normal weight patients. Schwarznau et al (3) reported that they Fig. 2.…”

Section: Discussionmentioning

confidence: 99%

“…Schwarznau et al. (3) reported that they have changed their center’s policy to not do living donor kidney transplantation in patients with a BMI ≥ 25. On the other hand, Marks et al.…”

Section: Discussionmentioning

confidence: 99%

“…There are conflicting reports regarding the effect of obesity on short‐ and long‐term graft and patient survival. In some studies, obesity was shown to be an independent risk factor for worse short‐ and long‐term graft and patient survival (1–5), while in other studies, differences between obese and non‐obese patients could not be observed (6–9). In contrast to these studies, Yamamoto et al.…”

mentioning

confidence: 99%

“…The prevailing information on obesity and its impact on graft and patient survival after kidney transplantation has been derived mostly in non‐African American patients (1–4, 7–14). Furthermore, the number of obese patients as well as the duration of follow‐up in single‐center studies has been limited.…”

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confidence: 99%

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Long‐term kidney transplant outcome in obese patients in a predominantly African American population

Karabıçak

Aytug

Lewis

et al. 2011

Clinical Transplantation

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The impact of obesity on long-term kidney transplant outcome has largely been studied in non-African American patients. This study seeks to determine differences in outcome between obese and non-obese patients after kidney transplantation, in a predominantly African American population. We reviewed 642 adult renal transplant recipients who received their transplants at SUNY Downstate Medical Center between 1998 and 2007. Sixty-six percent of the patients studied were African American. The patients were divided into five groups according to their BMI status: underweight <20, normal 20-24.9, overweight 25-29.9, obese 30-34.9, and morbidly obese ≥35. There were no differences in race, gender, cytomegalovirus infection, type of transplant, panel-reactive antibody, retransplant status, flow cytometry cross-match results, mycophenolate mofetil therapy, and total HLA mismatch status. The mean discharge serum creatinine in the morbidly obese group was significantly higher than in other groups (p < 0.001). The difference in creatinine level disappeared at six wk and six months (p > 0.5), respectively. Acute rejection rates, delayed graft function, graft survival, and patient survival were not different between the groups. The findings from this large single-center study suggest that obese and morbidly obese patients had similar outcomes compared to other weight groups. Obese and morbidly obese African American patients should not be excluded from kidney transplantation on the basis of weight alone.

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Post Kidney Transplant: Obesity

Kaur

Yerram

2018

Kidney Transplant Management

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Outcome of Living Donor Renal Transplantation in Obese Recipients

Cited by 16 publications

References 2 publications

Kidney transplantation in the morbidly obese: complicated but still better than dialysis

Kidney transplantation in the morbidly obese: complicated but still better than dialysis

Long‐term kidney transplant outcome in obese patients in a predominantly African American population

Post Kidney Transplant: Obesity

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