Outcome of molar pregnancies in Malaysia: A tertiary centre experience

Abstract

Gestational trophoblastic disease (GTD) is a common problem among Asian ethnics. A total of 102 women with molar pregnancies between 1 January 2005 and 31 December 2010, were analysed. The aim of the study was to determine the outcome of all molar pregnancies in our institution. The local incidence of molar pregnancy was 2.6 per 1,000 deliveries. A total of 48 women (47.1%) had complete hydatidiform mole and another 54 (52.9%) had partial mole. The mean age of the women with molar pregnancies was 32.0 ± 7.9 years. The mean gestational age at initial diagnosis was 11 weeks ± 3 days. The majority (97 women, 95.1%) had symptoms of vaginal bleeding and 18 (17.6%) women had a uterus larger than dates. A total of 48 (47.1%) women had ultrasound scan findings of 'snow-storm' appearance. None of the women with uncomplicated molar pregnancy had evidence of relapse following one undetectable serum β-hCG level. Four out of the 102 women (3.9%) developed persistent trophoblastic disease before attaining one undetectable serum β-hCG level. All four women required single agent methotrexate and they remained in remission. The prognosis for uncomplicated molar pregnancy is good. Establishment of a National Trophoblastic Centre is recommended to maintain optimal outcome.

Comparative Study of Differential Expression of Cyclin-E in Normal Placenta, Hydropic Abortus and Gestational Trophoblastic Disease

“…Our study had shown that, 78.95% patients of GTD were in first trimesters of pregnancy at the time of diagnosis, which was similar to the study done by Nirmala CK et al(2013) 17 and Simms-Stewart D et al (2013) 18 reported the median gestational age by date as 12 wks.…”

Women With a Partial Mole During Their First Pregnancy and Diagnosed Earlier in Gestation Are at Increased Risk of Developing Gestational Trophoblastic Neoplasia

“…18 Although the studies by Mourali et al 17 and Nirmala et al 18 did not compare gestational age at diagnosis between women who did and did not develop postmolar GTN, the gestational age at diagnosis in patients with partial molar pregnancies in these studies is similar to our experience. In addition, our findings together with those of Mourali et al 17 and Nirmala et al 18 highlight that many women are now diagnosed with a partial molar pregnancy in the first trimester. The routine use of the first trimester ultrasonography is likely the driving factor in this observation.…”

Outcome of gestational trophoblastic disease in a rural tertiary centre of Haryana, India

“…Early marriage and early conception may be the reason for lower mean age in our study. 12,13 The occurrence of a molar pregnancy strongly correlates with maternal age especially for women younger than 16 years and even more pronounced for those above 45 years. 14 women had a uterus larger than dates the but in our study in 54.6% patients uterine height was more than the period of gestation and this may be because of late presentation.…”