Outcome of mucormycosis after treatment: report of five cases

Bellazreg, F.; Hattab, Z.; Meksi, S. Gaïed; Mansouri, S.; Hachfi, W.; Kaabia, N.; Saïd, M. Ben; Létaief, A.

doi:10.1016/j.nmni.2014.12.002

Cited by 35 publications

(25 citation statements)

References 10 publications

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“…The responsible Mucorales were R. arrhizus in 3 cases and Lichtheimia corymbifera in 2 cases. [127]. One mucormycosis was reported among 321 renal transplant recipients [57].…”

Section: Mucormycosismentioning

confidence: 99%

Update on invasive fungal infections in the Middle Eastern and North African region

et al. 2020

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In the recent years, the epidemiology of invasive fungal infections (IFIs) has changed worldwide. This is remarkably noticed with the significant increase in high-risk populations. Although surveillance of such infections is essential, data in the Middle Eastern and North African (MENA) region remain scarce. In this paper, we reviewed the existing data on the epidemiology of different IFIs in the MENA region. Epidemiological surveillance is crucial to guide optimal healthcare practices. This study can help to guide appropriate interventions and to implement antimicrobial stewardship and infection prevention and control programs in countries.

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“…The responsible Mucorales were R. arrhizus in 3 cases and Lichtheimia corymbifera in 2 cases. [127]. One mucormycosis was reported among 321 renal transplant recipients [57].…”

Section: Mucormycosismentioning

confidence: 99%

Update on invasive fungal infections in the Middle Eastern and North African region

et al. 2020

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“…Cutaneous infections frequently occur in the limbs, usually as a dolorous erythematous to violet lesion, becoming necrotic, with discharge of a malodorous putrid and black exudate 2 . The observed auricular localization is exceptional 6 , and only other five confirmed cases [6][7][8][9][10] were found in the literature. Tuzcu et al described a fulminant case in a 17-year-old girl with diabetic ketoacidosis, septic signs and cellulitis of right external ear.…”

Section: Discussionmentioning

confidence: 99%

Fulminant Auricular Mucormycosis in a Diabetic Patient

Girardi¹,

Rocha²,

Sousa³

et al. 2017

Clin. Biomed. Res.

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Human mucormycosis is an atypical fungal infection that commonly affects the skin, but rarely the auricular region. A 32-year-old diabetic woman, agricultural worker, was admitted with swelling, redness and mild signs of epidermolysis of the left ear, associated with intense pain, facial paralysis and septic signs. The ear cellulitis evolved into necrosis of the same region on the following day. Surgical debridement was performed and antimycotic therapy was started with poor response. The patient died in 48h. Culture was confirmatory for Rhizopus sp. Keywords: Mucormycosis; fungal infections; diabetes; RhizopusMucormycosis is a rare but aggressive fungal infection, which occurs most often among patients with diabetes mellitus and other immunosuppressed individuals 1 . Most cases are associated to Rhizopus sp, a genus of common saprophytic fungi on plants and decaying organic matter. Most human infections are rhinocerebral and sinopulmonary. Cutaneous mucormycosis are also frequent and generally result from direct inoculation of fungal spores in the skin through any kind of injury, causing tissue necrosis by angioinvasion. The authors reported a case of a 32-year-old diabetic woman, agricultural worker, admitted to this service with a fulminant auricular mucormycosis. CASE REPORTA 32-year-old female patient from the public health system, with type 1 diabetes not adequately managed, was admitted to the author's service with pain on the left ear and tachypnea for 2 to 3 days. She reported a story of periauricular wounds about two days after the onset of the symptoms. She was an agricultural worker in the tobacco industry, and had been engaged in cleaning tobacco leaf stitching machines in the previous days. On clinical examination, a peripheral ipsilateral facial palsy was present. There was swelling, redness and mild signs of epidermolysis of the left ear, associated with intense pain, respiratory frequency of 25bpm and heart rate of 105 bpm. There was no fever. A significant ear canal edema made it impossible to perform a satisfactory otoscopy. The serum glucose level on arrival was 350 mg/dL. The first clinical hypothesis was a malignant external otitis caused by Herpes Zoster or bacterial infection. A 24-hour scheme of intravenous acyclovir and antibiotics was introduced. Clinical management for decompensated diabetes was also performed. In 24 hours, the patient got worse. Fever was present. The left auricular region started to show necrotic signs and she required intensive care for respiratory and hemodynamic support. The cranial CT showed no signs of fasciitis, mastoiditis or damage to the central nervous system. In few hours, the necrotic area of the ear became larger (Figure 1) and an urgent extensive debridement was performed, including ear amputation and resection of peripheral soft tissues. During the surgical procedure, there were signs of arterial and venous thrombosis and extensive gangrene of tissues, without purulent secretion. Mucormycosis was suspected and liposomal amphotericin B was intr...

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“…NMNI aims to provide an international forum for authors reporting facts in infectious and primarily tropical diseases and clinical microbiology that are new in one particular place and country. Accordingly, NMNI acknowledges contributions from emerging research teams, offering authors the opportunity to publish in their own language in addition to English; two such papers, dually accepted in French and English, have been published in 2015–2016 [1] , [2] and one in Spanish and English in 2017 [3] . In the meantime, NMNI has been included in PubMed Central, which has obviously increased its visibility and the interest of authors and readers.…”

Section: Introductionmentioning

confidence: 99%