1999
DOI: 10.1016/s0887-8994(99)00029-6
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Outcome of multiple subpial transections for autistic epileptiform regression

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Cited by 75 publications
(29 citation statements)
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“…The authors reported a case [80] of a child with autism and IEDs, without definite clinical seizures, who was treated with the modified Atkins diet and had complete suppression of his spikes, associated with improved speech and decreased hyperactivity. Finally, epilepsy surgery was also reported to cause variable cognitive and behavioral improvements in individuals with autistic regression either with [69][70][71] or without [45] intractable epilepsy. Unfortunately, there are no controlled clinical trials investigating the effect of treating epileptiform activity specifically in patients with autism.…”
Section: The Question Of Treatmentmentioning
confidence: 99%
“…The authors reported a case [80] of a child with autism and IEDs, without definite clinical seizures, who was treated with the modified Atkins diet and had complete suppression of his spikes, associated with improved speech and decreased hyperactivity. Finally, epilepsy surgery was also reported to cause variable cognitive and behavioral improvements in individuals with autistic regression either with [69][70][71] or without [45] intractable epilepsy. Unfortunately, there are no controlled clinical trials investigating the effect of treating epileptiform activity specifically in patients with autism.…”
Section: The Question Of Treatmentmentioning
confidence: 99%
“…A small number of studies in children with autistic regression and epilepsy (clinical history of seizures) has suggested the possible use of epilepsy surgery techniques with positive results. 134,135 In these cases, children suffered from intractable epilepsy and this was the indication for surgical treatment. In a postoperative study, there was improved seizure control but no improvement in autistic symptoms.…”
Section: Pharmacotherapymentioning
confidence: 99%
“…They both (AREE and LKS/ESES) have a high rate of epileptiform EEG abnormalities (particularly during sleep) associated with cognitive impairment. This connection has led to treatment of AREE with highdose steroids [Stefanatos et al, 1995] and even to performing surgery on these children [Nass et al, 1999;Neville et al, 1997;Szabo et al, 1999]. Some have even treated autistic regression children with normal EEG but abnormalities on evoked potentials, arguing that this condition, too, represents an extension of LKS [Stefanatos et al, 1995].…”
Section: Langauge Regression and Autistic Regression With Epileptiformentioning
confidence: 99%