“…The statistical heterogeneity was high at I 2 = 70%. Meta-analysis of 1331 patients from 28 evaluable studies 8,9,20,23,28,30,33-36,38-40,42,47,48,50,53-55,57,58,61,64,74,85 showed a pooled risk of OCF of 8.55% (95% CI, 5.71%-11.4%, I 2 = 71.8%) among patients undergoing free flap reconstruction (Figure 3A), compared to 8.02% (95% CI, 5.27%-10.8%, I 2 = 72.7%) among 1449 patients undergoing regional flap reconstruction from 34 evaluable studies 10,13,14,16,19,21,24-26,32,41,44,45,51,56,59,60,62,63,65-67,69,71,73,75,76,78,80,82-84 (Figure 3B). Pooled risk of fistula was 6.74% (95% CI, 4.50%-8.97%, I 2 = 38.6) among 1133 patients undergoing segm...…”