Outcome of nerve transfers for traumatic complete brachial plexus avulsion: results of 28 patients by DASH and NRS questionnaires

Liu, Y; Lao, Jie; Gao, Ke; Gu, Yong; Zhao, Xin

doi:10.1177/1753193411425330

Cited by 21 publications

(30 citation statements)

References 31 publications

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“…b-Catenin overexpression in muscle only, not in motor neurons, increases nerve branching possibly due to an increase in motor neuron numbers but independent of the level on neuromuscular activity. Defasciculation and branching occur prior to the establishment of functional NMJs between phrenic motor neurons and their target diaphragm muscles [14].…”

Section: Development Of the Nmjmentioning

confidence: 99%

Mechanisms controlling neuromuscular junction stability

Bloch‐Gallego

2014

Cell. Mol. Life Sci.

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The neuromuscular junction (NMJ) is the synaptic connection between motor neurons and muscle fibers. It is involved in crucial processes such as body movements and breathing. Its proper development requires the guidance of motor axons toward their specific targets, the development of multi-innervated myofibers, and a selective synapse stabilization. It first consists of the removal of excessive motor axons on myofibers, going from multi-innervation to a single innervation of each myofiber. Whereas guidance cues of motor axons toward their specific muscular targets are well characterized, only few molecular and cellular cues have been reported as clues for selecting and stabilizing specific neuromuscular junctions. We will first provide a brief summary on NMJ development. We will then review molecular cues that are involved in NMJ stabilization, in both pre- and post-synaptic compartments, considering motor neurons and Schwann cells on the one hand, and muscle on the other hand. We will provide links with pathologies and highlight advances that can be brought both by basic research on NMJ development and clinical data resulting from the analyses of neurodegeneration of synaptic connections to obtain a better understanding of this process. The goal of this review is to highlight the findings toward understanding the roles of poly- or single-innervations and the underlying mechanisms of NMJ stabilization.

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Section: Development Of the Nmjmentioning

confidence: 99%

Mechanisms controlling neuromuscular junction stability

Bloch‐Gallego

2014

Cell. Mol. Life Sci.

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“…This procedure, also known as neurotization, involves the surgical redirection of an intact nerve (donor nerve) to the distal part of the recipient nerve. As this connection is distal to the damaged site of the recipient nerve, it allows bypassing the injured nerve segment 7 .…”

Section: Introductionmentioning

confidence: 99%

Structured Motor Rehabilitation After Selective Nerve Transfers

Sturma¹,

Hruby²,

Farina³

2019

JoVE

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After severe nerve injuries, selective nerve transfers provide an opportunity to restore motor and sensory function. Functional recovery depends both on the successful re-innervation of the targets in the periphery and on the motor re-learning process entailing cortical plasticity. While there is an increasing number of methods to improve rehabilitation, their routine implementation in a clinical setting remains a challenge due to their complexity and long duration. Therefore, recommendations for rehabilitation strategies are presented with the aim of guiding medical doctors and therapists through the long-lasting rehabilitation process and providing step-by-step instructions for supporting motor re-learning. Directly after nerve transfer surgery, no motor function is present, and therapy should focus on promoting activity in the sensory-motor cortex areas of the paralyzed body part. After about two to six months (depending on the severity and modality of injury, the distance of nerve regeneration and many other factors), the first motor activity can be detected via electromyography (EMG). Within this phase of rehabilitation, multimodal feedback is used to re-learn the motor function. This is especially critical after nerve transfers, as muscle activation patterns change due to the altered neural connection. Finally, muscle strength should be sufficient to overcome gravity/resistance of antagonistic muscles and joint stiffness, and more functional tasks can be implemented in rehabilitation. Video Link The video component of this article can be found at https://www.jove.com/video/59840/ 9 , movements associated with ulnar nerve activity (such as hand closing or ulnar abduction of the wrist) are used for the activation of the biceps muscle directly after re-innervation. However, exercises based on this approach can be performed in other body parts as well. If special considerations are necessary to implement this in other body parts (e.g., the lower extremity), this is pointed out within the protocol. Independent from the body part affected, therapy sessions should not exceed 30 min as muscles become easily fatigued shortly after reinnervation 8 and successful training requires a patient's full commitment and focus.

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“…There are groups who argue that glutamine is the main food needed for tumor cell metabolism, so the administration of glutamine can enlarge the tumor and resistant to chemotherapy 17 . Yet another group believes that glutamine intake is necessary as a nutritional intake of cancer and has antioxidant effects by increasing Glutathione (GSH) that can inhibit tumor growth otherwise it is known to reduce the side effects of chemotherapy agents Doxorubicin 18 . Previous studies proving cisplatin may increase AIF expression in the renal proximal tubular cytosol, which then AIF out of the mitochondria, will accumulate in the cell nucleus that will induce apoptosis via the caspase-independent pathway 19 .…”

Section: Resultsmentioning

confidence: 99%

Effect of Glutamine Before Gets Cisplatin on Aif and Bcl-2 in the Evidence of Apoptosis Cell Tubulus Proximal in Rats Kidney of Rattus Norvegicus Strain Wistar

2020

IJFMT

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Background: Increased incidence of cancer in the world also increases the use of chemotherapy agents. Cisplatin is one of the most effective chemotherapy agents, often used for the treatment of various solid tumors. The therapeutic effect of cisplatin significantly increased with increasing dosage. Aim:The aim of the study was to investigate the role of glutamine in the prevention of apoptosis in proximal renal tubular epithelial cells administered by cisplatin chemotherapy, via an intrinsic caspase-independent apoptotic (AIF). Methods:The study was enrolled thirty male Wistar rats. The rats were divided into three groups of treatments, group A (negative control), group B has given intraperitoneal cisplatin dose of 20 mg/KgBB, group C administered the intravenous injection of glutamine 100 mg/KgBB for 7 days. Results: Analyzed ANOVA, mean expression of BCL-2 group B = 56.80 ± 4.39 than group A (control) = 63.7 ± 5.53 decreased not significant (p = 0.06), and mean expression of BCL-2 group C = 113.30 ± 8.92 increase significant compared to group A = 63.7 ± 5.53 (p = 0.000001) and group B = 56.80 ± 4.39 (p = 0.000001). The average AIF expression group C = 236.20 ± 17.58 decreased significantly compared to group B = 309.50 ± 8.08 (p = 0.000001). The average number of group apoptosis C = 151.80 ± 21.87 decreased significantly compared to group B = 255.20 ± 27.82 (p = 0.000001). Conclusion:Glutamine can inhibit the expression of AIF, increase BCL-2 expression, and decrease apoptosis of epithelial cells of the renal proximal tubules given cisplatin.

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Outcome of nerve transfers for traumatic complete brachial plexus avulsion: results of 28 patients by DASH and NRS questionnaires

Cited by 21 publications

References 31 publications

Mechanisms controlling neuromuscular junction stability

Mechanisms controlling neuromuscular junction stability

Structured Motor Rehabilitation After Selective Nerve Transfers

Effect of Glutamine Before Gets Cisplatin on Aif and Bcl-2 in the Evidence of Apoptosis Cell Tubulus Proximal in Rats Kidney of Rattus Norvegicus Strain Wistar

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