Outcome of Newly Diagnosed Glioblastoma Patients Treated by Radiotherapy plus Concomitant and Adjuvant Temozolomide: A Long-Term Analysis

Abstract

The study confirmed the effectiveness of radiotherapy plus temozolomide in newly diagnosed glioblastoma. It was established that the application of adjuvant temozolomide for at least 4 cycles is required to obtain a benefit from adjuvant therapy. However, further studies are needed to confirm these data.

Leptomeningeal spinal metastases from glioblastoma multiforme: treatment and management of an uncommon manifestation of disease

“…In support of this notion, our analysis revealed an average interval of 13 months between the diagnosis of primary intracranial GBM and spinal metastatic disease (Table 3), a latency period that parallels the median survival for most patients aggressively treated for an intracranial lesion. 25,43,56,77 Regarding intracranial tumor location, the majority of primary GBMs tend to be located in the third and lateral ventricles, with involvement of the fourth ventricle being uncommon in cases of CSF tumor dissemination. 57 The mechanism for dissemination involves invasion of the basement membrane structures, with subependymal growth and invasion of the choroid plexus, resulting in metastatic spread along the CSF pathways.…”

“…14 Patient management has remained challenging given the tumor's high proliferation rate and extensive invasion throughout normal brain tissue, both of which lead to a mean survival of 12-14 months after an initial diagnosis. 22,25,43,54,56 This neoplasm is associated with an extremely poor prognosis and one of the worst 5-year survival rates among all human cancers, with nearly inevitable tumor recurrence. Although as many as 90% of these lesions recur intracranially, 34,47,56 the last decade has seen both prolonged survival rates and escalating reports of distal CNS recurrences.…”

Antiangiogenic Effect of Bevacizumab: Application of Arterial Spin-Labeling Perfusion MR Imaging in a Rat Glioblastoma Model

“…Unenhanced anatomic T2-weighted images were collected by using a fast spin-echo sequence with the following parameters: TR/TE eff , 2000/45 ms; FOV, 33 ϫ 35 mm 2 ; matrix size, 256 ϫ 256; echo-train length, 4; 15 sections without gap; section thickness, 1 mm; 1 signal average; 2 dummy scans; and receiver bandwidth, 100 kHz.…”

“…1 Despite multiple treatment approaches, however, the prognosis for patients with GBM is still extremely dismal. 2,3 GBMs are highly vascularized tumors and have been seen as attractive targets for antiangiogenic therapies. 4 In particular, vascular endothelial growth factor has been identified as a critical regulator of angiogenesis.…”

PARP3 interacts with FoxM1 to confer glioblastoma cell radioresistance

“…To overcome glioblastoma radioresistance, adjuvant temozolomide (TMZ) chemotherapy has been combined with radiotherapy with certain success [5]. However, more efficient strategies for the treatment of glioblastoma are still required.…”