Outcome of older patients receiving mechanical ventilation

Esteban, Andrés; Anzueto, Antonio; Frutos‐Vivar, Fernando; Alía, Inmaculada; Ely, E. Wesley; Brochard, Laurent; Stewart, Thomas E.; Apezteguía, Carlos; Tobin, Martin J.; Nightingale, Peter; Matamis, Dimitrios; Pimentel, Jorge; Abroug, F.

doi:10.1007/s00134-004-2160-5

Cited by 116 publications

(64 citation statements)

References 22 publications

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“…We excluded studies published before 2001 because the practice of critical care and critical care outcomes has changed considerably since that time. 6,7 We also searched several other sources: we reviewed the reference lists of selected studies, we contacted experts in the fi eld to identify missed or unpublished studies, and we performed a manual examination of abstracts books from the main international meetings of critical care medicine (International Symposium on Intensive Care and Emergency Medicine, European Society Intensive Care Medicine Meeting, Society of Critical Care Medicine) between 2007 and 2014 to locate additional relevant titles. For studies published in abstract form, the primary author was contacted to identify manuscripts in progress.…”

Section: Search Methodsmentioning

confidence: 99%

The Volume-Outcome Relationship in Critical Care

Nguyen

Wallace

Yordanov

et al. 2015

Chest

119

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, MEDLINE and EMBASE were searched for studies assessing the relationship between admission volume and clinical outcomes in critical illness. Bibliographies were reviewed to identify other articles of interest, and experts were contacted about missing or unpublished studies. Of 127 studies reviewed, 46 met inclusion criteria, covering seven clinical conditions. Two investigators independently reviewed each article using a standardized form to abstract information on key study characteristics and results. 05-8.30]) were more likely to benefi t from admission to higher-volume centers compared with lower-volume centers. Studies that controlled for ICU or hospital organizational factors were less likely to fi nd a signifi cant volume-outcome relationship than studies that did not control for these factors. CONCLUSIONS:Critically ill patients generally benefi t from care in high-volume centers, with more substantial benefi ts in selected high-risk conditions. Th is relationship may in part be mediated by specifi c ICU and hospital organizational factors.

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Section: Search Methodsmentioning

confidence: 99%

The Volume-Outcome Relationship in Critical Care

Nguyen

Wallace

Yordanov

et al. 2015

Chest

119

View full text Add to dashboard Cite

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“…Also in the presence of acute kidney injury (AKI) most studies have documented that advanced age is independently associated with increase hospital mortality [12]. Mechanical ventilation, both invasive and noninvasive, is also associated with increased mortality in the elderly compared with younger age groups [13,14]. Studies of sepsis have shown an exponential increase in the population-based incidence of sepsis with age, followed closely by an increased mortality.…”

Section: Mortalitymentioning

confidence: 99%

The status of intensive care medicine research and a future agenda for very old patients in the ICU

Flaatten¹,

Lange²,

Artigas³

et al. 2017

Intensive Care Med

219

196

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The "very old intensive care patients" (abbreviated to VOPs; greater than 80 years old) are probably the fastest expanding subgroup of all intensive care unit (ICU) patients. Up until recently most ICU physicians have been reluctant to admit these VOPs. The general consensus was that there was little survival to gain and the incremental life expectancy of ICU admission was considered too small. Several publications have questioned this belief, but others have confirmed the poor long-term mortality rates in VOPs. More appropriate triage (resource limitation enforced decisions), admission decisions based on shared decision-making and improved prediction models are also needed for this particular patient group. Here, an expert panel proposes a research agenda for VOPs for the coming years.

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“…Older adults may be at greater risk for nosocomial infections and subsequent mortality compared with younger patients (29), although there is some evidence that older adults may be less likely to develop ventilator-associated pneumonia (30). Simple evidence-based interventions that can reduce rates of catheterrelated bloodstream infections (31) and ventilator-associated pneumonia (32) remain underused in the ICU setting.…”

Section: Nosocomial Infectionsmentioning

confidence: 99%

Toward an Integrated Research Agenda for Critical Illness in Aging

Milbrandt¹,

Eldadah²,

Nayfield³

et al. 2010

Am J Respir Crit Care Med

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Aging brings an increased predisposition to critical illness. Patients older than 65 years of age account for approximately half of all intensive care unit (ICU) admissions in the United States, a proportion that is expected to increase considerably with the aging of the population. Emerging research suggests that elderly survivors of intensive care suffer significant long-term sequelae, including accelerated age-related functional decline. Existing evidence-based interventions are frequently underused and their efficacy untested in older subjects. Improving ICU outcomes in the elderly will require not only better methods for translating sound science into improved ICU practice but also an enhanced understanding of the underlying molecular, physiological, and pathophysiological interactions of critical illness with the aging process itself. Yet, significant barriers to research for critical illness in aging exist. We review the state of knowledge and identify gaps in knowledge, research opportunities, and barriers to research, with the goal of promoting an integrated research agenda for critical illness in aging.

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Outcome of older patients receiving mechanical ventilation

Cited by 116 publications

References 22 publications

The Volume-Outcome Relationship in Critical Care

The Volume-Outcome Relationship in Critical Care

The status of intensive care medicine research and a future agenda for very old patients in the ICU

Toward an Integrated Research Agenda for Critical Illness in Aging

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