2013
DOI: 10.1007/s00268-013-2000-2
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Outcome of Patients with Aggressive Pseudomyxoma Peritonei Treated by Cytoreductive Surgery and Intraperitoneal Chemotherapy

Abstract: In aggressive PMP, cytoreduction with peritonectomy procedure plus HIPEC is a safe procedure that suggests an improvement to the survival rates. Because optimal cytoreduction is a primary prognostic factor for survival rates, this procedure would have to be performed in an experienced center with a low morbidity. Neoadjuvant chemotherapy has not demonstrated benefits in these patients and further research will be required.

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Cited by 21 publications
(12 citation statements)
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References 41 publications
(107 reference statements)
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“…when is compared to Mitomycin-C. The perfusion time in our study will be 60 min according to median life of Mitomycin C and according to a prophylactic procedure like this, with a dose of 15 mg/m2 [ 17 , 18 ]. The Mitomicyn C has been established as a better drug than Oxaliplatin in patients with peritoneal carcinoamtosis from colorectal cancer with a low index of PSDSS [ 19 ], just like the patients of our study.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…when is compared to Mitomycin-C. The perfusion time in our study will be 60 min according to median life of Mitomycin C and according to a prophylactic procedure like this, with a dose of 15 mg/m2 [ 17 , 18 ]. The Mitomicyn C has been established as a better drug than Oxaliplatin in patients with peritoneal carcinoamtosis from colorectal cancer with a low index of PSDSS [ 19 ], just like the patients of our study.…”
Section: Discussionmentioning
confidence: 99%
“…The absolute reduction of risk to develop a carcinomatosis means that in the 82% of patients would not get any benefit from the experimental treatment. This is only acceptable if the associated morbidity is relatively low which seems to be based on systematic review of the literature and our own experience [ 10 , 18 , 22 ].…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies support that cytoreduction with peritonectomy plus HIPEC is a safe procedure that suggests an improvement to the survival rates, even in aggressive cases [21, 22]. However, the authors in the recent study by Faris and Ryan conclude that the treatment of the low grade variants of PMP includes serial cytoreduction surgery, with data indicating possible, but unproven, benefit from HIPEC, whereas there is no consensus so far on the role of cytoreduction and HIPEC for the management of the more aggressive histological variants and peritoneal carcinomatosis [23].…”
Section: Discussionmentioning
confidence: 99%
“…The extent of peritoneal disease was classified using the peritoneal cancer index (PCI) [ 23 ]. The principles of cytoreductive surgery and HIPEC have been previously described by Sugarbaker PH [ 6 , 7 ]. After cytoreduction, HIPEC was administered using two alternative techniques: open (coliseum), which consists of suspending the entire abdominal wall and maintaining a cavity as deep as possible for the administration of HIPEC, or closed technique, which consists of filling the closed abdominal cavity with control to indicate the intra-abdominal volume and is complemented with an intra-abdominal CO 2 perfusion system to improve the distribution of the HIPEC agent [ 24 ].…”
Section: Methodsmentioning
confidence: 99%
“…CRS-HIPEC has proven to be an effective therapy for malignant tumors to enhance drug delivery in the peritoneal surface after CRS, which may help to eliminate microscopic peritoneal disease [ 6 13 ]. The local administration of chemotherapy increases the concentration of cytotoxic agents without systemic toxicity associated [ 14 ].…”
Section: Introductionmentioning
confidence: 99%