Outcome of patients with non-Hodgkin's lymphoma of the stomach after gastrectomy: clinicopathologic study and reclassification according to the revised European-American lymphoma classification

Mafune, Ken–ichi; Tanaka, Yoïchi; Suda, Yasuo; Izumo, Toshiyuki

doi:10.1007/pl00011736

Cited by 12 publications

(5 citation statements)

References 24 publications

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“…To describe the extent of the disease, most authors applied the Ann Arbor classification or its modification by Musshoff or Rohatiner 9,43. Localized stages (IE, IIE) are predominant in gastric lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey

et al. 2006

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Primary gastrointestinal lymphoma is a common presentation of non-Hodgkin's lymphoma. The main controversy arises when many aspects of its classification and management are under discussion, particularly regarding roles for surgical resection. The aim of this study was to evaluate clinicopathologic characteristics and the therapeutic outcome of primary gastrointestinal non-Hodgkin's lymphoma. We carried out a retrospective analysis of 74 patients who were presented to our center with histopathological diagnosis of primary gastro-intestinal non-Hodgkin's lymphoma between 1990 and 2001. All patients have been staged according to Lugano Staging System. For histopathological classification, International Working Formulation was applied. The treatment choice concerning the surgical or non-surgical management was decided by the initially acting physician. Treatment modalities were compared using the parameters of age, sex, histopathological results, stage, and the site of disease. Of the 74 patients, 31 were female and 43 were male, with a median age of 49 years (range 15-80). The stomach was the most common primary site and was seen in 51 of 74 patients (68.9%). The intermediate and high grade lymphomas constituted 91.9% of the all cases. In a median follow-up of 29 months (range 2-128), 20 out of 74 patients died. There was a three year overall survival rate in 65.4% of all patients. The three year overall survival rate was better in stage I and II1 patients who were treated with surgery plus chemotherapy (+/-RT) than those treated with chemotherapy alone (93.7% vs. 55.6%, p < 0.05). The stage and presence of B symptoms affected the disease free survival and overall survival significantly, but the histopathologic grade only affected the overall survival. On the basis of these results, we suggest that surgical resection is necessary before chemotherapy in early stage (stage I and II1) patients with gastrointestinal non-Hodgkin's lymphomas because of the significant survival advantage it would bring to the patient.

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Section: Discussionmentioning

confidence: 99%

Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey

et al. 2006

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“…In a randomized study on gastric NHL, results after chemotherapy or surgery plus chemotherapy (91% survival rate at 10 years) were significantly superior to results after surgery alone (54% survival rate at 10 years) or surgery plus radiotherapy (53% survival rate at 10 years) [22] . However, other investigators showed no difference in survival rates after chemotherapy alone versus surgery plus chemotherapy [8,23] .…”

Section: Discussionmentioning

confidence: 99%

“…Currently, the most controversial issue in the treatment of primary GI-NHLs is to determine whether or not the surgical treatment approach is necessary as the primary treatment modality. In patients with completely resectable early-stage disease, surgery has more of an advantage but could delay the use of chemotherapy, could be associated with some morbidity, and may also have a mortality rate of up to 10% [22] . Furthermore, it has also been suggested that surgery does not have a significant influence on OS and PFS rates.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin’s Lymphomas: 10 Years of Experience from a Single Center in Eastern Anatolia

Erkurt

Aydoğdu²,

Kuku³

et al. 2009

Med Princ Pract

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Objective: The objective of this retrospective study was to report the clinicopathological data and the treatment outcomes in patients with primary gastrointestinal non-Hodgkin’s lymphoma. Patients and Methods: We carried out a retrospective analysis of 41 patients (22 females, 18 males, median age 58 and range 18–90 years) who presented to our department with histopathological diagnosis of primary gastrointestinal non-Hodgkin’s lymphoma between 1995 and 2004. Results: The stomach was the most common extranodal site and was seen in 25 of 41 (61%) patients. At presentation 28 (68.3%) patients had gastrointestinal symptoms while 27 (65.9%) had B symptoms. The range of follow-up was 2–84 months with a median of 9 months. The overall survival rate was 3 years for 25 (61.2%) patients. The 3-year overall survival rate was better in patients with early-stage disease (stages I and II₁) who were treated with surgery plus chemotherapy and/or radiation therapy than in those treated with chemotherapy alone (91.6 vs. 50%, p < 0.05). The disease had a significant impact on both the progression-free survival and overall survival rates. Conclusion: Our data showed that surgical resection prior to postoperative chemotherapy was a better option for patients with early-stage disease with better patient survival.

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“…(5) In accordance with the published literature, the present case was in the seventh decade of life and presented with unilateral painless testicular mass but without B symptoms. (6) According to the Ann Arbor staging system, (3) the PTL of the present case is classified as stage I. Post-operatively, the patient received anthracycline-based chemotherapy and irradiation of the contralateral testis and central nervous system. Complete remission was achieved with no serious side effects of the chemoradiotherapy.…”

Section: Discussionmentioning

confidence: 99%

First Case Report of Primary Testicular Diffuse Large B-Cell Lymphoma from the Western Region of Saudi Arabia

Albasri

Elkablawy

Abdelbadie

et al. 2019

YJMS

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Primary testicular lymphoma (PTL) represents 1-2% of all types of non-Hodgkin lymphomas (NHLs) and 1-10% of testicular neoplasms. Up to the best of my knowledge, this is the first case of PTL of the diffuse large B-cell lymphoma (DLBCL) in a 60-yearold man presented with a painless mass in the left testis as revealed by physical examination in a tertiary care hospital in Al-Madinah Al-Munawarah in the western region of the Kingdom of Saudi Arabia (KSA). Radiological examination revealed a large well-defined heterogeneous predominantly hypo-echoic mass with increased vascularity in the upper portion of the testis. On the other hand, histopathological examination revealed a tumor involving the whole left testis, which was large (measuring 6 × 3.5 × 3.3 cm), solid and dark red with focal areas of hemorrhage and epididymal infiltration. Immunohistochemistry showed positivity of leucocyte common antigen (LCA), pan B-cell marker (CD20) and negativity of pan T-cell marker (CD3). Other immunohistochemical markers such as CD10, placental alkaline phosphatase (PLAP), cytokeratin, vimentin, desmin and S100 protein were also negative. However, there was a marked expression of Ki67 and Bcl2 markers. Accordingly, the diagnosis of DLBCL was established. The tumor was classified as stage I according to the Ann Arbor system. The case was treated by orchiectomy followed by prophylactic anthracycline-based chemotherapy and irradiation of the contralateral testis and central nervous system.

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Outcome of patients with non-Hodgkin's lymphoma of the stomach after gastrectomy: clinicopathologic study and reclassification according to the revised European-American lymphoma classification

Cited by 12 publications

References 24 publications

Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey

Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin's Lymphomas in Central Anatolia, in Turkey

Clinicopathologic Characteristics and Therapeutic Outcomes of Primary Gastrointestinal Non-Hodgkin’s Lymphomas: 10 Years of Experience from a Single Center in Eastern Anatolia

First Case Report of Primary Testicular Diffuse Large B-Cell Lymphoma from the Western Region of Saudi Arabia

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