Outcome of postpancreatectomy haemorrhage in the University Teaching Hospital of Nepal

Abstract

pancreatic adenocarcinoma). At least one dose of NSAIDs was administered in 82 (29.7%) patients. Ketorolac was the most common type of NSAIDs used (72/82, 87.8%). There were 43/276 (16%) POPF events in the cohort, 13/276 (4.7%) of which were clinically relevant pancreatic fistulas (ISGPF type B or C). NSAIDs use was not associated with a significant increase in the risk of POPF (OR: 1.33 95% confidence interval = 0.67e2.64, P = 0.444). There was also no correlation found between the type, the number of days or the postoperative day NSAIDs were used and the risk of POPF. The most important factor associated with POPF was disease pathologies other than pancreatic adenocarcinoma or chronic pancreatitis. Conclusions: This study suggests that there is no association between the use of postoperative NSAIDs and the risk of POPF. Further studies are needed to better understand the implications of NSAIDs use and postoperative complications.