Outcome of pregnancies when fathers are treated with 6-mercaptopurine for inflammatory bowel disease

Abstract

The incidence of pregnancy-related complications was significantly increased when the fathers used 6-MP within 3 months of conception.

The risk of congenital abnormalities in children fathered by men treated with azathioprine or mercaptopurine before conception

“…4,5 Recently, concerns have been raised regarding the risk of pregnancy-related complications in the offspring when the father is treated with mercaptopurine before conception. [6][7][8][9][10][11] The main concern is based on data from a cohort study reporting an increased risk of congenital abnormalities in the offspring when the fathers had taken mercaptopurine before conception (two cases of congenital abnormality in 50 exposed pregnancies and no cases in 90 controls). 6 Thus, the safety of mercaptopurine in the area of reproduction has been brought into question, and attention has been drawn to a potentially teratogenic effect.…”

“…[6][7][8][9][10][11] The main concern is based on data from a cohort study reporting an increased risk of congenital abnormalities in the offspring when the fathers had taken mercaptopurine before conception (two cases of congenital abnormality in 50 exposed pregnancies and no cases in 90 controls). 6 Thus, the safety of mercaptopurine in the area of reproduction has been brought into question, and attention has been drawn to a potentially teratogenic effect. 6,7,9,10 Pregnancy outcomes depend on both maternal and paternal factors, and the hypothesis of an increased risk of birth defects associated with paternal drug exposure is not new.…”

“…6 Thus, the safety of mercaptopurine in the area of reproduction has been brought into question, and attention has been drawn to a potentially teratogenic effect. 6,7,9,10 Pregnancy outcomes depend on both maternal and paternal factors, and the hypothesis of an increased risk of birth defects associated with paternal drug exposure is not new. Thus, for decades, animal studies have indicated that the paternal use of certain drugs may induce congenital abnormalities in the offspring, but human data are very sparse.…”

Understanding the Cautions and Contraindications of Immunomodulator and Biologic Therapies for Use in Inflammatory Bowel Disease

“…38 In their study, 57 men who fathered 140 pregnancies and their wives were interviewed. Pregnancies were divided into three groups: (1) 13 pregnancies where the father had taken 6-MP within three months prior to conception; (2) 37 where the father had discontinued 6-MP use three or more months before conception, and (3) 90 pregnancies where the father had never taken 6-MP prior to conception.…”

Magen-Darm-Beschwerden in der Schwangerschaft

“…Wenn auch we gen ei ner klei nen Fall zahl kontro vers dis ku tiert, gibt es Hin wei se da für, dass die Schwan ger schafts kom pli ka ti onsra te (Ab or te und Fehl bil dun gen) dann erhöht ist, wenn Män ner 6-Mer cap to pu rin bis in ner halb von 3 Mo na ten vor der Konzep ti on ein ge nom men hat ten. Hier sind sicher wei ter hin Stu di en not wen dig, um einen Zu sam men hang nach wei sen oder ausschlie ßen zu kön nen [32].…”