Outcome of Radical Surgical Resection for Craniopharyngioma with Hypothalamic Preservation: A Single-Center Retrospective Study of 1054 Patients

Shi, Xiaoyan; Zhou, Zhongqing; Wu, Bin; Zhang, Yongli; Qian, Hai; Sun, Yuming; Yang, Yang; Yu, Zaitao; Tang, Zhengyang; Lu, Shuaibin

doi:10.1016/j.wneu.2017.02.095

Cited by 34 publications

(19 citation statements)

References 58 publications

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“…Accordingly, the main goal of the treatment of CRs is to achieve a maximal safe resection with preservation of neurologic functions, rather than aggressive and radical tumor excision. 11,12…”

Section: Resection Ratementioning

confidence: 99%

Endoscopic and Microscopic Transsphenoidal Surgery of Craniopharyngiomas: A Systematic Review of Surgical Outcomes Over Two Decades

Zoli

Mazzatenta

Gompel

2017

J Neurol Surg A Cent Eur Neurosurg

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Section: Resection Ratementioning

confidence: 99%

Endoscopic and Microscopic Transsphenoidal Surgery of Craniopharyngiomas: A Systematic Review of Surgical Outcomes Over Two Decades

Zoli

Mazzatenta

Gompel

2017

J Neurol Surg A Cent Eur Neurosurg

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“…2 Surgical resection is the primary treatment for CP. 7 However, achieving gross-total resection (GTR) of either type of CP without any complications remains a challenge, 8 which underlines the necessity of new therapeutic options.…”

Section: Introductionmentioning

confidence: 99%

Expression and clinical significance of PD-L1, B7-H3, B7-H4 and VISTA in craniopharyngioma

Wang

Deng

Wang

et al. 2020

J Immunother Cancer

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BackgroundCraniopharyngioma (CP) is a common refractory tumor of the central nervous system. However, little is known about the expression and clinical significance of B7 family ligands/receptors in CP patients. Thus, we conducted the present study to address this issue in a cohort of 132 CP cases.MethodsWe mapped and quantified the expression of B7 family ligands/receptors molecules programmed cell death ligand 1 (PD-L1), B7-H3, B7-H4 and V-domain Ig-containing suppressor of T cell activation (VISTA) in 89 adamantinomatous-type CP and 43 papillary-type CP samples using immunohistochemistry and immunofluorescence. Associations between the marker levels, clinicopathological variables and survival were evaluated.ResultsThe positive rates of PD-L1, B7-H3, B7-H4 and VISTA in the cohort of 132 CP cases were 76.5%, 100%, 40.2% and 80.3%, respectively. The cut-off values of PD-L1, B7-H3, B7-H4 and PD-L1 expression were determined by survival receiver operating characteristic (ROC) package, which was 70, 182, 0 and 20, respectively. Elevated expressions of PD-L1, B7-H3, B7-H4 and VISTA were significantly associated with some clinicopathological characteristics. Kaplan-Meier analysis indicated that higher VISTA expressions correlated with better overall survival (OS) and progression-free survival (PFS) (p=0.0053 and p=0.0066, respectively). Multivariate Cox regression analysis indicated that VISTA was an independent prognostic factor for OS (p=0.018) but not for PFS (p=0.898).ConclusionsWe found variable expression of PD-L1, B7-H3, B7-H4 and VISTA proteins in CPs. The results suggest that the expression level of VISTA may be used as an important indicator to predict the OS and PFS of CPs. B7 family ligands/receptors could be potential immunotherapeutic targets when treating CPs.

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“…Craniopharyngiomas are generally treated with neurosurgery, which is sometimes followed by radiotherapy (1). Despite encouraging 10-year overall survival rates between 77 and 93% (2,4,5,6,7), longterm tumour-and treatment-related morbidity is common (2,5,6,7,8,9,10,11,12,13,14). Hypopituitarism, visual impairment and obesity are the most frequently observed long-term health conditions in patients with craniopharyngioma (6,7,8,9,10,11,14).…”

Section: Introductionmentioning

confidence: 99%

Excess morbidity and mortality in patients with craniopharyngioma: a hospital-based retrospective cohort study

Wijnen

Olsson

Heuvel‐Eibrink

et al. 2018

European Journal of Endocrinology

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Outcome of Radical Surgical Resection for Craniopharyngioma with Hypothalamic Preservation: A Single-Center Retrospective Study of 1054 Patients

Cited by 34 publications

References 58 publications

Endoscopic and Microscopic Transsphenoidal Surgery of Craniopharyngiomas: A Systematic Review of Surgical Outcomes Over Two Decades

Endoscopic and Microscopic Transsphenoidal Surgery of Craniopharyngiomas: A Systematic Review of Surgical Outcomes Over Two Decades

Expression and clinical significance of PD-L1, B7-H3, B7-H4 and VISTA in craniopharyngioma

Excess morbidity and mortality in patients with craniopharyngioma: a hospital-based retrospective cohort study

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