Outcome of Recurrent Autoinmune Hepatitis After Liver Transplantation

The Asian Pacific Association for the Study of the Liver clinical practice guidance: the diagnosis and management of patients with autoimmune hepatitis

“…A number of factors are reported to be associated with the recurrence of AIH, including the severity of pre-transplant AIH [322,329] and withdrawal of corticosteroids [327,330]. HLA locus mismatching was identified as a risk factor for recurrence [336] in one study but not in others [327][328][329]332].…”

“…On the other hand, recurrence of AIH in the graft after LT is common, and it is very challenging to determine the incidence of recurrent AIH, which is reported to be in the range of 7-42% [322][323][324][325][326][327][328][329][330][331][332] (Table 7). The inconsistency among studies is likely due to differences in diagnostic criteria, histological analysis (protocol or event-driven biopsy), small sample size in each study (no study with more than 100 patients enrolled), and follow-up time [333,334].…”

“…The inconsistency among studies is likely due to differences in diagnostic criteria, histological analysis (protocol or event-driven biopsy), small sample size in each study (no study with more than 100 patients enrolled), and follow-up time [333,334]. The rate of recurrence increases as the follow-up time increases after LT [323,329,330]. Neither the revised criteria, [335] nor the simplified criteria, [174] are validated for the diagnosis of recurrent AIH.…”