Outcome of small liver nodules detected by computed tomographic angiography in patients with hepatocellular carcinoma

Ohnishi, Hideki; Sakaguchi, Kohsaku; Nouso, Kazuhiro; Kobayashi, Yohnosuke; Nakamura, Shinichiro; Tanaka, Hironori; Miyake, Yasuhiro; Shoji, Bon; Iwadou, Shouta; Shiratori, Yasushi

doi:10.1007/s12072-010-9190-6

Cited by 7 publications

(3 citation statements)

References 29 publications

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“…Additionally, small HCC is associated with relatively benign behavior: Smaller lesions are less likely to show microvascular invasion , and nodules <3 cm were found not to be significantly associated with hepatic seeding of HCC . Single‐center longitudinal studies from Japan and San Francisco as well as a study modeling growth rates reported that most patients with early‐stage HCC do not progress rapidly for approximately six months after being placed on the transplant wait‐list.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the validity of model for end‐stage liver disease exception points for hepatocellular carcinoma patients with multiple nodules <2 cm

Samoylova

Dodge

Mehta

et al. 2014

Clinical Transplantation

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Liver transplant allocation policy does not give model for end-stage liver disease (MELD) exception points for patients with a single hepatocellular carcinoma (HCC) <2 cm in size, but does give points to patients with multiple small nodules. Because standard-of-care imaging for HCC struggles to differentiate HCC from other nodules, it is possible that a subset of patients receiving liver transplant for multiple nodules <2 cm in size does not have HCC. We evaluate risk of post-transplant HCC recurrence and wait-list dropout for patients with multiple small nodules using competing risks regression based on the Fine and Gray model. We identified 5002 adult HCC patients in the OPTN/UNOS dataset diagnosed and transplanted between January 2006 and September 2010. Compared to patients with >1 tumor <2 cm, risk of developing recurrence was significantly higher in patients with one or more tumors with only one tumor ≥2 cm (SHR 1.63, p = 0.009), as well as in patients with 2–3 tumors ≥2 cm (SHR 1.84, p = 0.02). Dropout risk was not significantly different among size categories. HCC recurrence risk was significantly lower in patients with multiple nodules <2 cm in size than in those with larger tumors, supporting the possibility that some patients received unnecessary transplants. The priority given to these patients must be re-examined.

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Section: Discussionmentioning

confidence: 99%

Evaluating the validity of model for end‐stage liver disease exception points for hepatocellular carcinoma patients with multiple nodules <2 cm

Samoylova

Dodge

Mehta

et al. 2014

Clinical Transplantation

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“…64 lesions were followed up and 18 of these increased in size and showed typical features of HCC. 28 HCC is the sixth most common cancer in the world. 29 Though histopathological diagnosis is the gold standard; the liberty of biopsy is not always available.…”

Section: Resultsmentioning

confidence: 99%

Guided FNAC of nodular lesions in liver

Jha¹,

Gupta²,

Pangarkar³

et al. 2020

ACHR

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Introduction:A focal mass or a nodule in the liver has become easily accessible to the needle of a pathologist, courtesy the rising numbers of guided FNAC. Precise localisation of lesions helps in studying the cytological features in greater detail, of the area in question. A targeted needle aspiration achieves high rates of sensitivity and specificity with regard to the varied spectrum of the pathologies encountered in liver especially when correlated with serological tests. Thus present study was carried out with aim to assess the role of guided FNAC in the diagnosis of nodular lesions of liver and to study their cytomorphology. Materials and Methods: It is an observational, prospective study of 130 adequate aspirates from liver nodules done at tertiary care hospital over two year period. All patients presenting with nodular liver mass detected on imaging techniques were selected for FNAC under USG or CT guidance. Another pass was taken from the surrounding liver to ascertain the presence of parenchymal changes like fatty change, cirrhosis and dysplasia. Results: Adequate aspirates from 130 cases were studied. Lesions were categorised into non neoplastic (11) and neoplastic which were further classified benign (1), primary malignancies (31HCC, 4 cholangiocarcinoma) metastasis ( 72) and undifferentiated malignancies (11) respectively on cytology. Conclusion: Guided FNAC of the liver is a rapid simple and precise method of identifying the pathology in liver nodules. It can be a useful modality to triage the patients and decide further line of management.

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“…CT arteriography (CTA) can be used to detect hepatocellular carcinomas (HCC) and their feeding arteries (1). For effective transarterial chemoembolization (TACE), the position and shape of the tumor and its feeding arteries must be known.…”

Section: Introductionmentioning

confidence: 99%

320-detector-row computed tomography arteriography using CO₂gas to detect malignant liver tumors

Sonoda

Nitta

Ushio

et al. 2012

Minimally Invasive Therapy & Allied Technologies

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Outcome of small liver nodules detected by computed tomographic angiography in patients with hepatocellular carcinoma

Cited by 7 publications

References 29 publications

Evaluating the validity of model for end‐stage liver disease exception points for hepatocellular carcinoma patients with multiple nodules <2 cm

Evaluating the validity of model for end‐stage liver disease exception points for hepatocellular carcinoma patients with multiple nodules <2 cm

Guided FNAC of nodular lesions in liver

320-detector-row computed tomography arteriography using CO₂gas to detect malignant liver tumors

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Outcome of small liver nodules detected by computed tomographic angiography in patients with hepatocellular carcinoma

Cited by 7 publications

References 29 publications

Evaluating the validity of model for end‐stage liver disease exception points for hepatocellular carcinoma patients with multiple nodules <2 cm

Evaluating the validity of model for end‐stage liver disease exception points for hepatocellular carcinoma patients with multiple nodules <2 cm

Guided FNAC of nodular lesions in liver

320-detector-row computed tomography arteriography using CO2gas to detect malignant liver tumors

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320-detector-row computed tomography arteriography using CO₂gas to detect malignant liver tumors