Outcome of special types of luminal breast cancer

Colleoni, Marco; Rotmensz, Nicole; Maisonneuve, Patrick; Mastropasqua, Mauro G.; Luini, Alberto; Veronesi, Giulia; Intra, Mattia; Montagna, Emilia; Cancello, Giuseppe; Cardillo, Anna; Mazza, M.; Perri, Gino; Iorfida, Monica; Pruneri, Giancarlo; Goldhirsch, Aron; Viale, Giulia

doi:10.1093/annonc/mdr461

Cited by 104 publications

(66 citation statements)

References 47 publications

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“…There is still controversy whether the prognosis of ILC differs from non-ILC [5,[27][28][29]. Contrary to other authors, we observed better DDFS and OS for ILC compared to non-ILC [10].…”

Section: Discussioncontrasting

confidence: 96%

Response and prognosis after neoadjuvant chemotherapy in 1,051 patients with infiltrating lobular breast carcinoma

Loibl

Volz

Mau

et al. 2014

Breast Cancer Res Treat

101

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Response and prognosis after neoadjuvant chemotherapy in 1,051 patients with infiltrating lobular breast carcinoma 123Breast Cancer Res Treat (2014) 144:153-162 DOI 10.1007/s10549-014-2861 pCR and this is not well correlated with further outcome. The mastectomy rate was considerably high in ILC patients even after obtaining a pCR. We, therefore, suggest to offer NACT mainly to ILC patients with HR-negative tumours.

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“…There is still controversy whether the prognosis of ILC differs from non-ILC [5,[27][28][29]. Contrary to other authors, we observed better DDFS and OS for ILC compared to non-ILC [10].…”

Section: Discussioncontrasting

confidence: 96%

Response and prognosis after neoadjuvant chemotherapy in 1,051 patients with infiltrating lobular breast carcinoma

Loibl

Volz

Mau

et al. 2014

Breast Cancer Res Treat

101

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“…The prognostic utility of the cribriform pattern has not been defined for lung adenocarcinoma, although several previous studies have reported correlations between cribriform pattern and prognosis in adenocarcinoma of various organs. 22–27 In prostatic adenocarcinoma, the cribriform pattern has been recognized as a higher grade pattern (Gleason score 4) than the acinar pattern, which comprises simple glandular structures (Gleason score 3). 22–24 Egashira et al reported that the presence of a cribriform structure was a significant risk factor for lymph node metastasis in invasive colon cancer.…”

Section: Discussionmentioning

confidence: 99%

“…18, 19 In addition, the cribriform arrangement has been recognized as a pattern of conventional adenocarcinoma in various organs. 20–27 To our knowledge, however, the prognostic significance of the cribriform pattern for lung adenocarcinoma has not been established.…”

Section: Introductionmentioning

confidence: 99%

The cribriform pattern identifies a subset of acinar predominant tumors with poor prognosis in patients with stage I lung adenocarcinoma: a conceptual proposal to classify cribriform predominant tumors as a distinct histologic subtype

et al. 2014

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The 2011 IASLC/ATS/ERS lung adenocarcinoma classification emphasizes the prognostic significance of histologic subtypes. However, one limitation of this classification is that the highest percentage of patients (~40%) is classified as acinar predominant tumors, and these patients display a spectrum of favorable and unfavorable clinical behaviors. We investigated whether the cribriform pattern can further stratify prognosis by histologic subtype. Tumor slides from 1038 patients with stage I lung adenocarcinoma (1995–2009) were reviewed. Tumors were classified according to the IASLC/ATS/ERS classification. The percentage of cribriform pattern was recorded, and the cribriform predominant subtype was considered as a subtype for analysis. The log-rank test was used to analyze the association between histologic variables and recurrence-free probability. The 5-year recurrence-free probability for patients with cribriform predominant tumors (n=46) wasa 70%. The recurrence-free probability for patients with cribriform predominant tumors was significantly lower than that for patients with acinar (5-year recurrence-free probability, 87%; P=0.002) or papillary predominant tumors (83%; P=0.020) but was comparable to that for patients with micropapillary (P=0.34) or solid predominant tumors (P=0.56). The recurrence-free probability for patients with ≥10% cribriform pattern tumors (n=214) was significantly lower (5-year recurrence-free probability, 73%) than that for patients with <10% cribriform pattern tumors (n=824; 84%; P<0.001). In multivariate analysis, patients with acinar predominant tumors with ≥10% cribriform pattern remained at significantly increased risk of recurrence, compared with those with <10% cribriform pattern (P=0.042). Cribriform predominant tumors should be considered a distinct subtype with a high risk of recurrence, and presence (≥10%) of the cribriform pattern is an independent predictor of recurrence, identifying a poor prognostic subset of acinar predominant tumors. Our findings highlight the important prognostic value of comprehensive histologic subtyping and recording the percentage of each histologic pattern, according to the IASLC/ATS/ERS classification with the addition of the cribriform subtype.

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“…Little attention has been dedicated in the past to identification of special types of breast cancer, that is, those displaying a distinct morphology might exhibit a distinct prognostic and predictive profile compared with invasive ductal carcinomas of no special type or not otherwise specified. 21 Within luminal A breast cancer, several special types display an extremely good prognosis, often approaching or equaling that of the general population. In particular, pure tubular and cribriform carcinomas represent a rare histologic type, correlated with a favorable prognosis.…”

Section: Tailored Treatments Of Luminal a Diseasementioning

confidence: 99%

Tailoring Adjuvant Treatments for the Individual Patient with Luminal Breast Cancer

Munzone

Curigliano

Colleoni

2013

Hematology/Oncology Clinics of North America

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Outcome of special types of luminal breast cancer

Abstract: The diagnosis of tubular, cribriform and lobular carcinomas carry distinct prognostic implications. The identification of these special types has a significant utility in luminal breast cancer and should be considered in therapeutic algorithms.

Cited by 104 publications

References 47 publications

Response and prognosis after neoadjuvant chemotherapy in 1,051 patients with infiltrating lobular breast carcinoma

Response and prognosis after neoadjuvant chemotherapy in 1,051 patients with infiltrating lobular breast carcinoma

The cribriform pattern identifies a subset of acinar predominant tumors with poor prognosis in patients with stage I lung adenocarcinoma: a conceptual proposal to classify cribriform predominant tumors as a distinct histologic subtype

Tailoring Adjuvant Treatments for the Individual Patient with Luminal Breast Cancer

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