Outcome of staged excision with pathologic margin control in high-risk basal cell carcinoma of the head region

Abstract

Background High-risk basal cell carcinoma involves a significant rate of basal cell carcinoma that requires Mohs micrographic surgery for definitive treatment. Staged excision with pathologic margin control is a simple, accessible, and curative procedure suggested for the treatment of high-risk basal cell carcinoma. Objective To evaluate the results of staged excision of high-risk basal cell carcinoma in the head region. Methods This interventional study was performed on patients with high-risk basal cell carcinoma, who underwent staged excision until the margins were free of tumor. Results A total of 122 patients (47 females and 75 males) with mean age of 57.66 ± 9.13 years were recruited in this study. Nasal and nodular types were the most common of both clinical and pathologic forms, respectively. Further, 89.3 % of cases were cured by staged excision after four years of follow-up. There was a significant relationship between treatment outcomes and recurrent lesions, multiplicity of risk factors, long-standing disease, and pathologic type. There was also a significant association between the number of surgical excisions and multiplicity of risk factors, as well as recurrence, location, and size of basal cell carcinoma. Study limitations Lack of magnetic resonance imaging assessment in cases of suspected perineural invasion. Conclusions High-risk basal cell carcinoma had a high cure rate by staged excision. Patients with more risk factors and those with nasal and recurrent basal cell carcinoma required more staged excisions. Failure of treatment is more probable in patients with more risk factors, long-standing lesions, and high-risk pathologic and recurrent basal cell carcinomas.

Assessment of Standard Surgical Excision Efficacy and Analysis of Recurrence-Associated Factors in 343 Cases of Nasal Basal Cell Carcinoma: a single-center retrospective study

“…Devine et al (2017) similarly identified a younger sample in Great Britain, with a mean age of 72.5 years [21]. We also reviewed other studies where, in contrast to our data, the majority of subjects were male [3,[22][23][24]. Ghanadan et al (2014) attributed this gender distribution to factors such as women's higher usage of SPF face protection products and men's increased outdoor exposure leading to greater direct UV radiation exposure [25].…”

Assessment of Standard Surgical Excision Efficacy and Analysis of Recurrence-Associated Factors in 343 Cases of Nasal Basal Cell Carcinoma: A Single-Center Retrospective Study

“…Devine et al (2017) similarly identified a younger sample in Great Britain, with a mean age of 72.5 years [ 21 ]. We also reviewed other studies where, in contrast to our data, the majority of subjects were male [ 3 , 22 , 23 , 24 ]. Ghanadan et al (2014) attributed this gender distribution to factors such as women’s higher usage of products containing SPF (sun protection factor) for face protection from ultraviolet (UV) rays and men’s increased outdoor exposure leading to greater direct UV radiation exposure [ 25 ].…”

Comparison of Sonographic Characteristics Between Superficial Basal Cell Carcinoma and Non‐Superficial Basal Cell Carcinomas

“…1,2 Surgical excision is the most common treatment associated with high clearance rates, at an expense of aesthetic and functional morbidity, especially in T-zone lesions. 3 Currently, clinical guidelines 4 advocate that the selection of treatment plans should base on the pathological subtype of BCC. Non-surgical treatments are recommended for sBCC because it is the thinnest of all the subtypes of BCC and generally does not grow aggressively.…”

“…Superficial basal cell carcinoma (sBCC) is a common subtype of basal cell carcinoma (BCC), which is generally considered to be a non‐aggressive form of skin malignancy and accounts for ~10–17% of all BCC 1,2 . Surgical excision is the most common treatment associated with high clearance rates, at an expense of aesthetic and functional morbidity, especially in T‐zone lesions 3 . Currently, clinical guidelines 4 advocate that the selection of treatment plans should base on the pathological subtype of BCC.…”