Outcome of surgical treatment for patients with scirrhous carcinoma of the stomach

Otsuji, Eigo; Kuriu, Yoshiaki; Okamoto, Kazuma; Ochiai, Toshiya; Ichikawa, Daisuke; Hagiwara, Akeo; Yamagishi, Hisakazu

doi:10.1016/j.amjsurg.2004.06.010

Cited by 72 publications

(81 citation statements)

References 14 publications

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“…It is characterized by poorly differentiated tumor cells that diffusely infiltrate the gastric wall, thus provoking reactive fibrosis [7]. The prognosis reported in the current literature remains extremely poor [8,9].…”

Section: Discussionmentioning

confidence: 99%

Gastric linitis plastica: which role for surgical resection?

et al. 2011

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Background The role of surgery for gastric linitis plastica (GLP) is questioned. This study aimed to analyze our experience in the surgical treatment of GLP with specific reference to the resectability rate, prognosis, and mode of recurrence. Methods Results of surgery were analyzed in 102 patients with GLP. Results Of the 102 patients, 92 underwent surgical exploration, with resection performed in 60 cases. R2 resection was carried out in 20 patients and R1 in 12 patients, while the resection was considered potentially curative (R0) in 28 (27.5%). Overall, the median (95% confidence interval [CI]) survival time was 5.7 (3.7-7.5) months, with none of the patients alive at the end date of the study. For R0 patients the median (95% CI) survival time was 15.8 (11-20.7) months. The great majority of recurrences were intra-abdominal (peritoneal and/or locoregional), with a systemic component of the relapse that was rarely observed (5 cases). Conclusions After primary surgery, GLP showed a poor prognosis without regard to the extent or type of resection. The failure of surgical treatment related mainly to the peritoneal spread of the disease. Specifically designed multimodality treatment protocols should be tested in this setting.

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Section: Discussionmentioning

confidence: 99%

Gastric linitis plastica: which role for surgical resection?

et al. 2011

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“…Clinical and pathological evidence indicated that the metastatic spread of tumours through lymphatic vessels to local/ regional LNs is an early event in metastatic disease for many solid human tumours (Stacker et al, 2002b). Lymph node metastasis is an important prognostic indicator for patient with DGC (Otsuji et al, 2004;Kunisaki et al, 2005). Tumour cells can escape from the primary site by entering existing vessels or new vessels actively recruited into the primary tumour (Stacker et al, 2002b).…”

Section: Discussionmentioning

confidence: 99%

“…In most solid tumours (including gastric cancer), the spread of cancer cells through the lymphatics to regional lymph nodes (LN) is a frequent event in the initial process of cancer dissemination (Stacker et al, 2002a) and is an important prognostic indicator for patient outcome (Otsuji et al, 2004;Kunisaki et al, 2005;Yashiro et al, 2005). Nodal metastasis is considered to be dependent on the tumour-induced lymphangiogenesis or the invasion of preexisting lymphatic vessels (Clarijs et al, 2001).…”

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confidence: 99%

Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model

et al. 2009

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BACKGROUND: Vascular endothelial growth factor receptor-3 (VEGFR-3) signalling mediates lymphangiogenesis and lymphatic invasion; however, the effect of VEGFR-3 inhibition on the lymph node (LN) metastasis remains unclear. The aim of this study is to clarify the benefit of a VEGFR-3 inhibitor Ki23057 for LN metastasis. METHODS: Ki23057 was administered orally to gastric cancer models created by orthotopic inoculation of diffuse-type gastric cancer cells, OCUM-2MLN. The effects of Ki23057 on lymphatic vessel invasion, lymphatic vessel density, and VEGFR-3 phosphorylation were examined by immunostaining or immunoblotting. RESULTS: Ki23057 inhibited the autophosphorylation of VEGFR-3, with IC 50 values of 4.3 nM in the cell-free kinase assay. Murine gastric cancer models created by the orthotopic inoculation of OCUM-2MLN cells showed the diffusely infiltrating growth and frequently developed LN metastasis. The oral administration of Ki23057 significantly (Po0.01) reduced the size of orthotopic tumours and the number of the metastatic LN in gastric cancer models. The degree of lymphatic invasion and lymphangiogenesis was significantly (Po0.05) lower in the gastric tumours treated by Ki23057. Ki23057 inhibited the phosphorylation of VEGFR-3 of lymphatic endothelial cells in gastric tumours. CONCLUSION: The inhibition of lymphangiogenesis targeting VEGFR-3 phosphorylation is a therapeutic strategy for inhibiting LN metastasis of diffuse-type gastric cancer.

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“…1b). Scirrhous carcinomas account for about 10% of all gastric carcinomas, and carry a worse prognosis than other types of gastric carcinoma, reflecting their rapid proliferation of cancer cells [3][4][5]. The common features of scirrhous gastric cancer include rapidly progressive invasion, and a high frequency of metastasis to the peritoneum [6].…”

Section: Introductionmentioning

confidence: 99%

Cancer–Stromal Interactions in Scirrhous Gastric Carcinoma

Yashiro

Hirakawa

2010

Cancer Microenvironment

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Fibroblasts play an important role in the progression, growth and spread of gastric cancers. Cancer-stroma interactions have been especially evident in the scirrhous type of gastric carcinoma. Fibroblasts are associated with the cancer progression at the primary and metastatic site. The proliferative and invasive ability of scirrhous gastric cancer cells are closely associated with the growth factors produced by organ-specific fibroblasts. Fibroblasts are therefore a key determinant in the malignant progression of gastric cancer and represent an important target for cancer therapies.

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Outcome of surgical treatment for patients with scirrhous carcinoma of the stomach

Cited by 72 publications

References 14 publications

Gastric linitis plastica: which role for surgical resection?

Gastric linitis plastica: which role for surgical resection?

Effects of VEGFR-3 phosphorylation inhibitor on lymph node metastasis in an orthotopic diffuse-type gastric carcinoma model

Cancer–Stromal Interactions in Scirrhous Gastric Carcinoma

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