Outcome of Tumor Lysis Syndrome with Hydration and Alkalinization in Children with Acute Lymphoblastic Leukemia

Abstract

Objective: To observe the out come of tumor lysis syndrome (TLS) following treatment with hydration and alkalinization in children with acute lymphoblastic leukemia.Methodology: This is an observational study which included 30 diagnosed ALL children who were at high risk of developing TLS in the Department of Pediatric Hematology & Oncology, BSMMU, from January 2010 to July 2010. Result: The mean (±SD) age was found 10.2±2.9 years and maximum (46.7%) numbers were found between 11 to 15 years. Male female ratio was 2.3:1. High risk patients for developing TLS presented with huge organomegaly such as hepatomegaly, splenomegaly, and lymphadenopathy associated with fever, anemia, and bony tenderness. For diagnosis of Acute Lymphoblastic Leukemia (ALL) bone marrow study was done in all patients and immunophenotyping in 40.0% patients. Hydration, Alkalinization, Tab Allopurinol and Oral Aluminum hydroxide were used in all study patients while treatment. WBC and serum uric acid were found higher in all patients during baseline investigation. After hydration and Alkalinization serum potassium, serum phosphate, serum calcium and serum creatinine level were normal within 72 hours and serum uric acid within day five. Mortality was found 6.7% and the cause of mortality was septicemia. DOI: http://dx.doi.org/10.3329/bjms.v11i4.12598 Bangladesh Journal of Medical Science Vol. 11 No. 04 Oct’12

Clinicopathological Study of Acute Lymphoblastic Leukemia - A Multiparameter Study

“…[11] Among the clinical symptoms the fever was the most common clinical symptoms at presentation in our study (2014) and the similar findings were reported by Khalid Hassan, et al (1993) [12] and Sultana A., et al (2010). [13] The second most common presenting clinical feature was reported as pallor (100%) by Khalid Hassan, et al (1993) and anemia by Sultana A, et al (2010) while in present study (2014) second most common presenting clinical feature was weakness (70.27%). Third most prevalent clinical feature in ALL cases was bleeding gum (73%) as reported by Khalid Hassan, et al (1993) while in our study (2014) loss of appetite was reported as third most common presenting clinical feature.…”

Beetroot-Carrot Juice Intake either Alone or in Combination with Antileukemic Drug 'Chlorambucil' As A Potential Treatment for Chronic Lymphocytic Leukemia

“…There was a reduction in the level of uric acid. It was established that the elevated level of uric acid (hyperucimea) was caused by tumor lysis syndrome (caused by the breakdown products of dying cancer cells) of leukocytes cells [ 8 ]. Stopping the beetroot-carrot juice for 1 month, then resumption of the juice for another 2 months and 11 days, leads to an increase in leukocytes and lymphocytes counts and increase in uric acid level.…”