Outcome of Using Medical Grade Calcium Sulfate Hemihydrate (DentoGen) in Unilateral Alveolar Cleft Repair

Abstract

Objectives:The aim of this prospective study was to evaluate the efficacy of fast setting (DentoGen) bone substitute for secondary alveolar cleft repair. Materials and Methods:Ten patients with complete unilateral cleft lip and palate were included for alveolar cleft repair with fast setting (DentoGen) without autogenous bone graft in 2017 and 2018. Pre-operation and 6 months post-operation CBCT were used for measurement of bone density and bone volume in cleft site. The data was analyzed by using Pearson's correlation coefficient test and paired sample t-test via SPSS software version 24. Results:The mean age of patients in this study was 10.4±2.657 years. The pre-operative mean alveolar cleft volume was 0.8996±0.117cm 3 . Six months after grafting with fast setting (DentoGen) graft, satisfactory bone formation was observed in all patients except two patients. The mean bone density of cleft site was 303±42.843 HU which was significantly lower than the non-cleft side, and the mean percentage of new bone formation was 64.74±10.290% compared with original cleft volume. Conclusion:Calcium sulfate hemihydrate (DentoGen) can represent a promising alternative to autogenous bone graft in repairing small unilateral alveolar cleft during mixed dentition.