Outcome predictors in SARS-CoV-2 disease (COVID-19): The prominent role of IL-6 levels and an IL-6 gene polymorphism in a western Sicilian population

Giannitrapani, Lydia; Augello, Giuseppa; Mirarchi, Luigi; Amodeo, Simona; Veronese, Nicola; Sasso, Bruna Lo; Giglio, Rosaria Vincenza; Licata, Anna; Barbagallo, Mario; Ciaccio, Marcello; Cervello, Melchiorre; Soresi, Maurizio

doi:10.1016/j.jinf.2022.04.043

Cited by 10 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Giannitrapani et al observed higher IL-6 values in 16% non-critical and 53% critical patients. 20 In a previous study, the dynamic evolution of IL-6 was shown to predict the 180-day all-cause mortality in patients with acute heart failure. 21 In addition, acute and persistent elevations of IL-6 levels after ST-elevation myocardial infarction is associated with all-cause mortality.…”

Section: Discussionmentioning

confidence: 96%

Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients

Zhang,

Jiao

2023

IDR

View full text Add to dashboard Cite

Purpose Elevated levels of the inflammatory marker interleukin-6 (IL-6) and cardiac injury marker N-terminal pro-B-type natriuretic peptide (NT-proBNP) have been observed in patients with coronavirus disease 2019 (COVID-19). However, the relationship between IL-6 and NT-proBNP levels remains unclear. Therefore, we investigated the relationship between IL-6 and NT-proBNP levels in patients with COVID-19. Patients and Methods This was a cross-sectional study. Consecutive patients with COVID-19 were included herein. The independent and dependent target variables were the IL-6 and NT-proBNP levels, respectively, measured at baseline. Univariate and multivariate linear regression analyses and curve fitting were also performed. Results The average age of the 121 selected participants was 49.8 ± 15.8 years old, and 48.8% (59/121) were male. The estimated β value between Ln -transformed IL-6 and NT-proBNP was 0.28 (95% confidence interval [CI] 0.12–0.44, P = 0.001) in univariate logistic regression analysis and 0.09 (95% CI −0.04–0.21, P = 0.176) in the fully adjusted model. This relationship was nonlinear, with a point of 2.7, and the β values (and CIs) for the left (<2.7) and right (≥2.7) sides of the inflection point were −0.06 (95% CI −0.23–0.12, P = 0.534) and 0.77 (95% CI 0.18–1.37, P = 0.016) in the fully adjusted model, respectively. Conclusion Our results suggest a nonlinear association between IL-6 and NT-proBNP levels. Higher IL-6 levels are associated with NT-proBNP in patients with COVID-19.

show abstract

Section: Discussionmentioning

confidence: 96%

Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients

Zhang,

Jiao

2023

IDR

View full text Add to dashboard Cite

show abstract

“…There are ample theoretical reasons that heritable genetic variation could affect SARS-CoV-2 infection, beginning with the viral requirement for surface receptors to gain entry to the cytoplasm [ 58 ] and running through multiple immune response pathways generating the "cytokine storm" which has been prominently noted in the pathogenesis of COVID-19 [ 59 ]. A number of genetic variants have been associated with morbidity and mortality, including variants in the angiotensin converting enzyme 1 ( ACE1 ) gene, [ 60 ] the TMPRSS2 gene, [ 61 ] the IL-6 gene [ 62 ] and others extensively reviewed by Ishak et al [ 63 ] The COVID-19 Host Genetics Initiative, a massive ascertainment of nearly 50,000 cases from 19 countries has identified 13 genome-wide loci related to either initial infection, or morbidity [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study

Best,

Erdei,

Haack

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background Although COVID-19 infection has been associated with a number of clinical and environmental risk factors, host genetic variation has also been associated with the incidence and morbidity of infection. The CRP gene codes for a critical component of the innate immune system and CRP variants have been reported associated with infectious disease and vaccination outcomes. We investigated possible associations between COVID-19 outcome and a limited number of candidate gene variants including rs1205. Methodology/Principal findings The Strong Heart and Strong Heart Family studies have accumulated detailed genetic, cardiovascular risk and event data in geographically dispersed American Indian communities since 1988. Genotypic data and 91 COVID-19 adjudicated deaths or hospitalizations from 2/1/20 through 3/1/23 were identified among 3,780 participants in two subsets. Among 21 candidate variants including genes in the interferon response pathway, APOE, TMPRSS2, TLR3, the HLA complex and the ABO blood group, only rs1205, a 3’ untranslated region variant in the CRP gene, showed nominally significant association in T-dominant model analyses (odds ratio 1.859, 95%CI 1.001–3.453, p = 0.049) after adjustment for age, sex, center, body mass index, and a history of cardiovascular disease. Within the younger subset, association with the rs1205 T-Dom genotype was stronger, both in the same adjusted logistic model and in the SOLAR analysis also adjusting for other genetic relatedness. Conclusion A T-dominant genotype of rs1205 in the CRP gene is associated with COVID-19 death or hospitalization, even after adjustment for relevant clinical factors and potential participant relatedness. Additional study of other populations and genetic variants of this gene are warranted.

show abstract

“…gene, [60] the TMPRSS2 gene, [61] the IL-6 gene [62] and others extensively reviewed by Ishak et al [63] The COVID-19 Host Genetics Initiative, a massive ascertainment of nearly 50,000 cases from 19 countries has identified 13 genome-wide loci related to either initial infection, or morbidity. [64] The rs1205 variant is a C/T single nucleotide polymorphism in the 3' untranslated region of the C-reactive protein gene (CRP), with a prevalence of the C allele ranging from ~ 0.67 in European populations, to ~ 0.40 in Asian populations,[65] and 0.51 to 0.54 in the present study.…”

Section: Discussionmentioning

confidence: 99%

Genetic Variant rs1205 is Associated with COVID-19 Outcomes: The Strong Heart Study and Strong Heart Family Study

Best

Erdei

Haack

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Although COVID-19 infection has been associated with a number of clinical and environmental risk factors, host genetic variation has also been associated with the incidence and morbidity of infection. The CRP gene codes for a critical component of the innate immune system and CRP variants have been reported associated with infectious disease and vaccination outcomes. We investigated possible associations between COVID-19 outcome and a limited number of candidate gene variants including rs1205. Methodology/Principal Findings: The Strong Heart and Strong Heart Family studies have accumulated detailed genetic, cardiovascular risk and event data in geographically dispersed American Indian communities since 1988. Chi-square tests, logistic regression and generalized linear mixed models (implemented in SOLAR) were used in analysis. Genotypic data and 91 COVID-19 adjudicated deaths or hospitalizations from 2/1/20 through 3/1/23 were identified among 3,780 participants in two subsets. Among 21 candidate variants including genes in the interferon response pathway, APOE, TMPRSS2, TLR3, the HLA complex and the ABO blood group, only rs1205, a 3' untranslated region variant in the CRP gene, showed nominally significant association in T-dominant model analyses (odds ratio 1.859, 95%CI 1.001-3.453, p=0.049) after adjustment for age, sex, center, body mass index, and a history of cardiovascular disease. Within the younger subset, association with the rs1205 T-Dom genotype was stronger, both in the same adjusted logistic model and in the SOLAR analysis also adjusting for other genetic relatedness. Conclusion: A T-dominant genotype of rs1205 in the CRP gene is associated with COVID-19 death or hospitalization, even after adjustment for relevant clinical factors and potential participant relatedness. Additional study of other populations and genetic variants of this gene are warranted.

show abstract

Outcome predictors in SARS-CoV-2 disease (COVID-19): The prominent role of IL-6 levels and an IL-6 gene polymorphism in a western Sicilian population

Cited by 10 publications

References 7 publications

Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients

Nonlinear Relationship Between Interleukin-6 and NT-proBNP at Admission in Hospitalized COVID-19 Patients

Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study

Genetic Variant rs1205 is Associated with COVID-19 Outcomes: The Strong Heart Study and Strong Heart Family Study

Contact Info

Product

Resources

About